2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands.
Article Details
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Haubmann C, Hubner H, Gmeiner P
2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands.
Bioorg Med Chem Lett. 1999 Jul 19;9(14):1969-72.
- PubMed ID
- 10450964 [ View in PubMed]
- Abstract
The phenylpiperazinylmethyl substituted pyrrolylmethylenemalononitriles of type 3 and 4 were synthesized and evaluated as strong and selective dopamine D4 receptor ligands.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Clozapine Dopamine D2 receptor Ki (nM) 39 N/A N/A Details Clozapine Dopamine D2 receptor Ki (nM) 28 N/A N/A Details Clozapine Dopamine D3 receptor Ki (nM) 960 N/A N/A Details Clozapine Dopamine D4 receptor Ki (nM) 16 N/A N/A Details