Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors.
Article Details
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Lucas MC, Carter DS, Cai HY, Lee EK, Schoenfeld RC, Steiner S, Villa M, Weikert RJ, Iyer PS
Novel, achiral aminoheterocycles as selective monoamine reuptake inhibitors.
Bioorg Med Chem Lett. 2009 Aug 15;19(16):4630-3. doi: 10.1016/j.bmcl.2009.06.076. Epub 2009 Jun 25.
- PubMed ID
- 19592243 [ View in PubMed]
- Abstract
A variety of novel aminoheterocycle scaffolds as selective monoamine reuptake inhibitors have been prepared and one of these scaffolds is achiral. The main elements responsible for hERG channel, CYP2D6 and CYP3A4 inhibition were identified.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Duloxetine Sodium-dependent dopamine transporter Ki (nM) 251.19 N/A N/A Details Duloxetine Sodium-dependent noradrenaline transporter Ki (nM) 7.94 N/A N/A Details Duloxetine Sodium-dependent serotonin transporter Ki (nM) 0.501 N/A N/A Details