Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amides.
Article Details
- CitationCopy to clipboard
Lau JF, Jeppesen CB, Rimvall K, Hohlweg R
Ureas with histamine H3-antagonist receptor activity--a new scaffold discovered by lead-hopping from cinnamic acid amides.
Bioorg Med Chem Lett. 2006 Oct 15;16(20):5303-8.
- PubMed ID
- 16908150 [ View in PubMed]
- Abstract
A group of tri and tetrasubstituted urea derivatives have been found to be hH(3)-antagonists. The most potent compounds were found in the class of (piperazine-1-yl)-(piperidine-1-yl)-methanones which in addition showed negligible hERG inhibition.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Bepridil Potassium voltage-gated channel subfamily H member 2 Ki (nM) 444 N/A N/A Details Thioridazine Potassium voltage-gated channel subfamily H member 2 Ki (nM) 869 N/A N/A Details