Quinol-4-ones as steroid A-ring mimetics in nonsteroidal dissociated glucocorticoid agonists.
Article Details
- CitationCopy to clipboard
Regan J, Lee TW, Zindell RM, Bekkali Y, Bentzien J, Gilmore T, Hammach A, Kirrane TM, Kukulka AJ, Kuzmich D, Nelson RM, Proudfoot JR, Ralph M, Pelletier J, Souza D, Zuvela-Jelaska L, Nabozny G, Thomson DS
Quinol-4-ones as steroid A-ring mimetics in nonsteroidal dissociated glucocorticoid agonists.
J Med Chem. 2006 Dec 28;49(26):7887-96.
- PubMed ID
- 17181172 [ View in PubMed]
- Abstract
We report on the nuclear receptor binding affinities, cellular activities of transrepression and transactivation, and anti-inflammatory properties of a quinol-4-one and other A-ring mimetic containing nonsteroidal class of glucocorticoid agonists.
DrugBank Data that Cites this Article
- Binding Properties
Drug Target Property Measurement pH Temperature (°C) Dexamethasone Glucocorticoid receptor IC 50 (nM) 3 N/A N/A Details Prednisolone Glucocorticoid receptor IC 50 (nM) 15 N/A N/A Details