Canakinumab, a fully-human mAb against IL-1beta for the potential treatment of inflammatory disorders.

Article Details

Citation

Church LD, McDermott MF

Canakinumab, a fully-human mAb against IL-1beta for the potential treatment of inflammatory disorders.

Curr Opin Mol Ther. 2009 Feb;11(1):81-9.

PubMed ID
19169963 [ View in PubMed
]
Abstract

Novartis AG is developing canakinumab, an intravenously or subcutaneously infused, fully human mAb that neutralizes the bioactivity of human IL-1beta, which is involved in several inflammatory disorders. Canakinumab has promising clinical safety and pharmacokinetic properties, and demonstrated potential for the treatment of cryopyrin-associated periodic syndromes (CAPS) and possibly for other complex inflammatory diseases, such as rheumatoid arthritis, systemic-onset juvenile idiopathic arthritis (SoJIA), COPD disease and ocular diseases. Currently in phase III clinical development, canakinumab was recently granted EU and US Orphan Drug status for SoJIA and CAPS. Early clinical trials have established the administration of canakinumab every 2 weeks to be safe and effective, offering a considerable advantage over the existing treatment with the human IL-1 receptor antagonist anakinra, which must be injected daily and which is often poorly tolerated by patients. The availability of more than one IL-1 targeting biological agent is undoubtedly advantageous, not only for patients and clinicians, but also for the elucidation of disease mechanisms.

DrugBank Data that Cites this Article

Drugs
Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
CanakinumabInterleukin-1 betaProteinHumans
Yes
Binder
Antibody
Details