Human monoamine oxidase A and B genes exhibit identical exon-intron organization.
Article Details
- CitationCopy to clipboard
Grimsby J, Chen K, Wang LJ, Lan NC, Shih JC
Human monoamine oxidase A and B genes exhibit identical exon-intron organization.
Proc Natl Acad Sci U S A. 1991 May 1;88(9):3637-41.
- PubMed ID
- 2023912 [ View in PubMed]
- Abstract
Monoamine oxidases A and B [MAOA and MAOB; amine:oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3.4] play important roles in the metabolism of neuroactive, vasoactive amines and the Parkinsonism-producing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Human MAOA and MAOB genes isolated from X chromosome-specific libraries span at least 60 kilobases, consist of 15 exons, and exhibit identical exon-intron organization. Exon 12 codes for the covalent FAD-binding-site and is the most conserved exon; the MAOA and MAOB exon 12 products share 93.9% peptide identity. These results suggest that MAOA and MAOB are derived from duplication of a common ancestral gene and provide insight on the structural/functional relationship of the enzyme products.