Polysaccharide-Lyases

Name
Polysaccharide-Lyases
Accession Number
DBCAT000167
Description

A group of carbon-oxygen lyases. These enzymes catalyze the breakage of a carbon-oxygen bond in polysaccharides leading to an unsaturated product and the elimination of an alcohol. EC 4.2.2.

Drugs
DrugDrug Description
HyaluronidaseAn enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents.
Hyaluronidase (human recombinant)An enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents.
Elosulfase alfaA lysosomal glycosaminoglycan (GAG)-specific enzyme indicated as an enzyme replacement therapy for Mucopolysaccharidosis type IV A.
Pegvorhyaluronidase alfaPegvorhyaluronidase alfa is under investigation in clinical trial NCT02241187 (Two Stage Study Of Single Dose PEGPH20 And Cetuximab In Patients With Pancreatic Adenocarcinoma Prior To Surgical Resection).
Drugs & Drug Targets
DrugTargetType
HyaluronidaseHyaluronic acidtarget
HyaluronidaseTransforming growth factor beta-1 proproteintarget
Hyaluronidase (human recombinant)Hyaluronic acidtarget
Hyaluronidase (human recombinant)Transforming growth factor beta-1 proproteintarget