Phenylurea Compounds

Accession Number

DBCAT001627

Description

Compounds that include the amino-N-phenylamide structure.

Drugs

Drug	Drug Description
Celiprolol	A beta-blocker for the management of hypertension and angina pectoris.
Triclocarban	An antibacterial agent used in liquid soaps and body washes.
Nicarbazin	Not Annotated
Imidocarb	Imidocarb is a urea derivative used in veterinary medicine as an antiprotozoal agent for the treatment of infection with Babesia and other parasites.
Sorafenib	A kinase inhibitor used to treat unresectable liver carcinoma, advanced renal carcinoma, and differentiated thyroid carcinoma.
NS-3728	Investigated for use/treatment in anemia (sickle cell) and cancer/tumors (unspecified).

Drugs & Drug Targets

Drug	Target	Type
Celiprolol	Beta-1 adrenergic receptor	target
Celiprolol	Beta-2 adrenergic receptor	target
Celiprolol	Beta-3 adrenergic receptor	target
Celiprolol	Alpha-2A adrenergic receptor	target
Celiprolol	Alpha-2B adrenergic receptor	target
Celiprolol	Alpha-2C adrenergic receptor	target
Celiprolol	Cytochrome P450 2D6	enzyme
Triclocarban	Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI	target
Triclocarban	Cytochrome P450 1A1	enzyme
Triclocarban	Cytochrome P450 1B1	enzyme
Imidocarb	Acetylcholinesterase	target
Sorafenib	Serine/threonine-protein kinase B-raf	target
Sorafenib	Receptor-type tyrosine-protein kinase FLT3	target
Sorafenib	RAF proto-oncogene serine/threonine-protein kinase	target
Sorafenib	Vascular endothelial growth factor receptor 3	target
Sorafenib	Platelet-derived growth factor receptor beta	target
Sorafenib	Mast/stem cell growth factor receptor Kit	target
Sorafenib	Vascular endothelial growth factor receptor 2	target
Sorafenib	Cytochrome P450 3A4	enzyme
Sorafenib	UDP-glucuronosyltransferase 1A9	enzyme
Sorafenib	Cytochrome P450 2B6	enzyme
Sorafenib	Cytochrome P450 2C8	enzyme
Sorafenib	Cytochrome P450 3A5	enzyme
Sorafenib	Cytochrome P450 3A7	enzyme
Sorafenib	Cytochrome P450 2C9	enzyme
Sorafenib	ATP-binding cassette sub-family C member 4	transporter
Sorafenib	ATP-dependent translocase ABCB1	transporter
Sorafenib	ATP-binding cassette sub-family C member 2	transporter
Sorafenib	Broad substrate specificity ATP-binding cassette transporter ABCG2	transporter
Sorafenib	Cytochrome P450 1A2	enzyme
Sorafenib	Cytochrome P450 2C19	enzyme
Sorafenib	Cytochrome P450 2D6	enzyme
Sorafenib	UDP-glucuronosyltransferase 1A1	enzyme
Sorafenib	RalA-binding protein 1	transporter
Sorafenib	Fibroblast growth factor receptor 1	target
Sorafenib	Proto-oncogene tyrosine-protein kinase receptor Ret	target
Sorafenib	Vascular endothelial growth factor receptor 1	target
Sorafenib	Solute carrier organic anion transporter family member 1B1	transporter
Sorafenib	Epidermal growth factor receptor	target