D-tartaric acid
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Identification
- Generic Name
- D-tartaric acid
- DrugBank Accession Number
- DB01694
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 150.0868
Monoisotopic: 150.016437924 - Chemical Formula
- C4H6O6
- Synonyms
- (-)-Tartaric acid
- (−)-(S,S)-tartaric acid
- (−)-D-tartaric acid
- (−)-Weinsäure
- (2S,3S)-(−)-tartaric acid
- (2S,3S)-tartaric acid
- (S,S)-(−)-tartaric acid
- (S,S)-Tartaric acid
- D-(−)-tartaric acid
- D-tartaric acid
- D-threaric acid
- Linksweinsäure
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism U2,3-diketo-L-gulonate reductase Not Available Escherichia coli (strain K12) UGalactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 Not Available Humans UTriggering receptor expressed on myeloid cells 1 Not Available Humans UProbable ATP-dependent RNA helicase DDX6 Not Available Humans UCytochrome P450 Not Available Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) UHypoxia-inducible factor 1-alpha inhibitor Not Available Humans UD-3-phosphoglycerate dehydrogenase Not Available Mycobacterium tuberculosis UAcyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase Not Available Helicobacter pylori (strain ATCC 700392 / 26695) UV-type proton ATPase subunit C 1 Not Available Humans UdTDP-4-dehydrorhamnose 3,5-epimerase Not Available Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) UPutative uncharacterized protein Not Available Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) UPhosphonoacetate hydrolase Not Available Pseudomonas fluorescens UPutative uncharacterized protein Not Available Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Classification
- Not classified
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- RRX6A4PL3C
- CAS number
- 147-71-7
- InChI Key
- FEWJPZIEWOKRBE-LWMBPPNESA-N
- InChI
- InChI=1S/C4H6O6/c5-1(3(7)8)2(6)4(9)10/h1-2,5-6H,(H,7,8)(H,9,10)/t1-,2-/m0/s1
- IUPAC Name
- (2S,3S)-2,3-dihydroxybutanedioic acid
- SMILES
- O[C@@H]([C@H](O)C(O)=O)C(O)=O
References
- Synthesis Reference
Eiji Sato, Akira Yanai, "Method for preparing d-tartaric acid." U.S. Patent US3957579, issued February, 1961.
US3957579- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0029878
- KEGG Compound
- C02107
- PubChem Compound
- 447315
- PubChem Substance
- 46508249
- ChemSpider
- 388726
- BindingDB
- 50427212
- 1371315
- ChEBI
- 15672
- ChEMBL
- CHEMBL1200861
- ZINC
- ZINC000000895296
- PDBe Ligand
- TAR
- Wikipedia
- Tartaric_acid
- PDB Entries
- 1cb7 / 1ccw / 1em2 / 1hvv / 1jz8 / 1mze / 1rpa / 1wqs / 2c1l / 2cdq … show 156 more
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 2 Completed Treatment Generalized Anxiety 1
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
Property Value Source melting point (°C) 172.5 °C PhysProp water solubility 1E+006 mg/L (at 25 °C) YALKOWSKY,SH & DANNENFELSER,RM (1992) - Predicted Properties
Property Value Source Water Solubility 161.0 mg/mL ALOGPS logP -1.3 ALOGPS logP -1.8 Chemaxon logS 0.03 ALOGPS pKa (Strongest Acidic) 2.72 Chemaxon pKa (Strongest Basic) -4.3 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 115.06 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 26.21 m3·mol-1 Chemaxon Polarizability 11.61 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption - 0.532 Blood Brain Barrier + 0.8035 Caco-2 permeable - 0.8783 P-glycoprotein substrate Non-substrate 0.7685 P-glycoprotein inhibitor I Non-inhibitor 0.9789 P-glycoprotein inhibitor II Non-inhibitor 0.9739 Renal organic cation transporter Non-inhibitor 0.9633 CYP450 2C9 substrate Non-substrate 0.8684 CYP450 2D6 substrate Non-substrate 0.9168 CYP450 3A4 substrate Non-substrate 0.7763 CYP450 1A2 substrate Non-inhibitor 0.9357 CYP450 2C9 inhibitor Non-inhibitor 0.9071 CYP450 2D6 inhibitor Non-inhibitor 0.9544 CYP450 2C19 inhibitor Non-inhibitor 0.9695 CYP450 3A4 inhibitor Non-inhibitor 0.8884 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9877 Ames test Non AMES toxic 0.9289 Carcinogenicity Non-carcinogens 0.6841 Biodegradation Ready biodegradable 0.9397 Rat acute toxicity 1.4627 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.9914 hERG inhibition (predictor II) Non-inhibitor 0.9749
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Chromatographic Properties
Collision Cross Sections (CCS)
Adduct CCS Value (Å2) Source type Source [M-H]- 126.1229803 predictedDarkChem Lite v0.1.0 [M-H]- 125.8115803 predictedDarkChem Lite v0.1.0 [M-H]- 128.0832803 predictedDarkChem Lite v0.1.0 [M-H]- 123.60757 predictedDeepCCS 1.0 (2019) [M+H]+ 128.1871803 predictedDarkChem Lite v0.1.0 [M+H]+ 127.0226803 predictedDarkChem Lite v0.1.0 [M+H]+ 128.8330803 predictedDarkChem Lite v0.1.0 [M+H]+ 126.2256 predictedDeepCCS 1.0 (2019) [M+Na]+ 126.2440803 predictedDarkChem Lite v0.1.0 [M+Na]+ 126.0354803 predictedDarkChem Lite v0.1.0 [M+Na]+ 127.0094803 predictedDarkChem Lite v0.1.0 [M+Na]+ 134.78288 predictedDeepCCS 1.0 (2019)
Targets
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1. Details2,3-diketo-L-gulonate reductase
- Kind
- Protein
- Organism
- Escherichia coli (strain K12)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
- Specific Function
- Catalyzes the reduction of 2,3-diketo-L-gulonate in the presence of NADH, to form 3-keto-L-gulonate.
- Gene Name
- dlgD
- Uniprot ID
- P37672
- Uniprot Name
- 2,3-diketo-L-gulonate reductase
- Molecular Weight
- 36572.395 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Udp-galactose:beta-n-acetylglucosamine beta-1,3-galactosyltransferase activity
- Specific Function
- Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, ...
- Gene Name
- B3GAT1
- Uniprot ID
- Q9P2W7
- Uniprot Name
- Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1
- Molecular Weight
- 38255.675 Da
References
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Scaffold protein binding
- Specific Function
- Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers...
- Gene Name
- TREM1
- Uniprot ID
- Q9NP99
- Uniprot Name
- Triggering receptor expressed on myeloid cells 1
- Molecular Weight
- 26386.385 Da
References
4. DetailsProbable ATP-dependent RNA helicase DDX6
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Rna helicase activity
- Specific Function
- In the process of mRNA degradation, may play a role in mRNA decapping.
- Gene Name
- DDX6
- Uniprot ID
- P26196
- Uniprot Name
- Probable ATP-dependent RNA helicase DDX6
- Molecular Weight
- 54416.42 Da
5. DetailsCytochrome P450
- Kind
- Protein
- Organism
- Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039)
- Pharmacological action
- Unknown
- General Function
- Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q746J6
- Uniprot Name
- Cytochrome P450
- Molecular Weight
- 44255.71 Da
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Zinc ion binding
- Specific Function
- Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 w...
- Gene Name
- HIF1AN
- Uniprot ID
- Q9NWT6
- Uniprot Name
- Hypoxia-inducible factor 1-alpha inhibitor
- Molecular Weight
- 40285.25 Da
7. DetailsD-3-phosphoglycerate dehydrogenase
- Kind
- Protein
- Organism
- Mycobacterium tuberculosis
- Pharmacological action
- Unknown
- General Function
- Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.
- Specific Function
- Nad binding
- Gene Name
- serA
- Uniprot ID
- P9WNX3
- Uniprot Name
- D-3-phosphoglycerate dehydrogenase
- Molecular Weight
- 54553.635 Da
- Kind
- Protein
- Organism
- Helicobacter pylori (strain ATCC 700392 / 26695)
- Pharmacological action
- Unknown
- General Function
- Acyl-[acyl-carrier-protein]-udp-n-acetylglucosamine o-acyltransferase activity
- Specific Function
- Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
- Gene Name
- lpxA
- Uniprot ID
- O25927
- Uniprot Name
- Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
- Molecular Weight
- 29855.195 Da
9. DetailsV-type proton ATPase subunit C 1
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- General Function
- Transporter activity
- Specific Function
- Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic act...
- Gene Name
- ATP6V1C1
- Uniprot ID
- P21283
- Uniprot Name
- V-type proton ATPase subunit C 1
- Molecular Weight
- 43941.245 Da
References
- Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [Article]
10. DetailsdTDP-4-dehydrorhamnose 3,5-epimerase
- Kind
- Protein
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- Pharmacological action
- Unknown
- General Function
- Dtdp-4-dehydrorhamnose 3,5-epimerase activity
- Specific Function
- Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.
- Gene Name
- rmlC
- Uniprot ID
- Q9HU21
- Uniprot Name
- dTDP-4-dehydrorhamnose 3,5-epimerase
- Molecular Weight
- 20766.29 Da
11. DetailsPutative uncharacterized protein
- Kind
- Protein
- Organism
- Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Not Available
- Gene Name
- Not Available
- Uniprot ID
- Q9KVB4
- Uniprot Name
- Uncharacterized protein
- Molecular Weight
- 14647.545 Da
12. DetailsPhosphonoacetate hydrolase
- Kind
- Protein
- Organism
- Pseudomonas fluorescens
- Pharmacological action
- Unknown
- General Function
- Phosphonoacetate hydrolase activity
- Specific Function
- Specifically hydrolyzes phosphonoacetate. Does not have activity on other organophosphonates or acetates.
- Gene Name
- phnA
- Uniprot ID
- Q51782
- Uniprot Name
- Phosphonoacetate hydrolase
- Molecular Weight
- 44239.04 Da
13. DetailsPutative uncharacterized protein
- Kind
- Protein
- Organism
- Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
- Pharmacological action
- Unknown
- General Function
- Not Available
- Specific Function
- Oxidoreductase activity
- Gene Name
- Not Available
- Uniprot ID
- A0A0H2URW2
- Uniprot Name
- Uncharacterized protein
- Molecular Weight
- 27147.305 Da
Drug created at June 13, 2005 13:24 / Updated at June 12, 2020 16:51