Antimonous acid
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Identification
- Generic Name
- Antimonous acid
- DrugBank Accession Number
- DB02453
- Background
Not Available
- Type
- Small Molecule
- Groups
- Experimental
- Structure
- Weight
- Average: 172.78
Monoisotopic: 171.912037006 - Chemical Formula
- H3O3Sb
- Synonyms
- Stiborous acid
- Trihydroxyantimonite(III)
Pharmacology
- Indication
Not Available
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- Pharmacodynamics
Not Available
- Mechanism of action
Target Actions Organism UArsenical pump-driving ATPase Not Available Escherichia coli - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
Not Available
- Clearance
Not Available
- Adverse Effects
- Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.
- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.Not Available
- Food Interactions
- Not Available
Categories
- Drug Categories
- Not Available
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of inorganic compounds known as metalloid hydroxides. These are inorganic compounds in which the largest oxoanion is hydroxide, and in which the heaviest atom not in an oxoanion is a metalloid.
- Kingdom
- Inorganic compounds
- Super Class
- Mixed metal/non-metal compounds
- Class
- Metalloid oxoanionic compounds
- Sub Class
- Metalloid hydroxides
- Direct Parent
- Metalloid hydroxides
- Alternative Parents
- Inorganic antimony salts / Metalloid salts / Inorganic oxides / Inorganic hydrides
- Substituents
- Inorganic antimony salt / Inorganic hydride / Inorganic metalloid salt / Inorganic oxide / Inorganic salt / Metalloid hydroxide
- Molecular Framework
- Not Available
- External Descriptors
- antimony oxoacid (CHEBI:49870)
- Affected organisms
- Not Available
Chemical Identifiers
- UNII
- Not Available
- CAS number
- Not Available
- InChI Key
- SZOADBKOANDULT-UHFFFAOYSA-K
- InChI
- InChI=1S/3H2O.Sb/h3*1H2;/q;;;+3/p-3
- IUPAC Name
- stiborous acid
- SMILES
- [H]O[Sb](O[H])O[H]
References
Clinical Trials
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Not Available
- Dosage Forms
- Not Available
- Prices
- Not Available
- Patents
- Not Available
Properties
- State
- Solid
- Experimental Properties
- Not Available
- Predicted Properties
Property Value Source logP -1.6 Chemaxon pKa (Strongest Acidic) 18.37 Chemaxon pKa (Strongest Basic) -0.85 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 60.69 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 7.69 m3·mol-1 Chemaxon Polarizability 5.76 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 0.7927 Blood Brain Barrier + 0.9045 Caco-2 permeable - 0.7089 P-glycoprotein substrate Non-substrate 0.8617 P-glycoprotein inhibitor I Non-inhibitor 0.9733 P-glycoprotein inhibitor II Non-inhibitor 0.9936 Renal organic cation transporter Non-inhibitor 0.9439 CYP450 2C9 substrate Non-substrate 0.8115 CYP450 2D6 substrate Non-substrate 0.8472 CYP450 3A4 substrate Non-substrate 0.7773 CYP450 1A2 substrate Non-inhibitor 0.9211 CYP450 2C9 inhibitor Non-inhibitor 0.9029 CYP450 2D6 inhibitor Non-inhibitor 0.9373 CYP450 2C19 inhibitor Non-inhibitor 0.9281 CYP450 3A4 inhibitor Non-inhibitor 0.9746 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9663 Ames test Non AMES toxic 0.8348 Carcinogenicity Carcinogens 0.6573 Biodegradation Not ready biodegradable 0.7344 Rat acute toxicity 1.7564 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.8358 hERG inhibition (predictor II) Non-inhibitor 0.9621
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
- Not Available
- Chromatographic Properties
Collision Cross Sections (CCS)
Not Available
Targets
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1. DetailsArsenical pump-driving ATPase
- Kind
- Protein
- Organism
- Escherichia coli
- Pharmacological action
- Unknown
- General Function
- Atp binding
- Specific Function
- Anion-transporting ATPase. Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic ...
- Gene Name
- arsA
- Uniprot ID
- P08690
- Uniprot Name
- Arsenical pump-driving ATPase
- Molecular Weight
- 63187.75 Da
References
Drug created at June 13, 2005 13:24 / Updated at July 02, 2020 13:17