Hairy Cell Leukemia (HCL)

Also known as: Hairy Cell Leukemia / Leukemia, Hairy Cell / Hairy cell leukaemia / Hairy-cell Leukemia / HCL / Hairy cell leukemia not having achieved remission / Hairy cell leukemia (disorder) / Hairy cell leukemia (morphologic abnormality) / Leukemic reticuloendotheliosis / Leukaemic reticuloendotheliosis

Drug	Drug Name	Drug Description
DB00242	Cladribine	A purine antimetabolite used to treat Multiple Sclerosis (MS) and hairy cell leukemia.
DB00034	Interferon alfa-2a	A form of recombinant human interferon used to stimulate the innate antiviral response in the treatment of hepatitis B and C viruses.
DB00105	Interferon alfa-2b	A form of recombinant human interferon used to treat hepatitis B and C infection, genital warts, hairy cell leukemia, follicular lymphoma, malignant melanoma, and AIDs-related Kaposi's sarcoma.
DB12688	Moxetumomab pasudotox	A CD22-specific antibody conjugated to a truncated exotoxin used to treat relapsed or refractory hairy cell leukemia in patients who have already been treated with a purine nucleoside analog and one other treatment.
DB00552	Pentostatin	An adenosine deaminase inhibitor used to treat hairy cell leukemia.

Drug	Drug Name	Target	Type
DB00242	Cladribine	Purine nucleoside phosphorylase	target
DB00242	Cladribine	DNA	target
DB00242	Cladribine	Deoxycytidine kinase	enzyme
DB00242	Cladribine	Ribonucleoside-diphosphate reductase large subunit	target
DB00242	Cladribine	Ribonucleoside-diphosphate reductase subunit M2	target
DB00242	Cladribine	Ribonucleoside-diphosphate reductase subunit M2 B	target
DB00242	Cladribine	DNA polymerase alpha catalytic subunit	target
DB00242	Cladribine	DNA polymerase epsilon catalytic subunit A	target
DB00242	Cladribine	DNA polymerase epsilon subunit 2	target
DB00242	Cladribine	DNA polymerase epsilon subunit 3	target
DB00242	Cladribine	DNA polymerase epsilon subunit 4	target
DB00242	Cladribine	ATP-binding cassette sub-family G member 2	transporter
DB00242	Cladribine	Solute carrier family 28 member 3	transporter
DB00242	Cladribine	P-glycoprotein 1	transporter
DB00242	Cladribine	Equilibrative nucleoside transporter 1	transporter
DB00242	Cladribine	Deoxyguanosine kinase, mitochondrial	enzyme
DB00242	Cladribine	Poly [ADP-ribose] polymerase 1	target
DB00034	Interferon alfa-2a	Interferon alpha/beta receptor 1	target
DB00034	Interferon alfa-2a	Interferon alpha/beta receptor 2	target
DB00034	Interferon alfa-2a	Cytochrome P450 1A2	enzyme
DB00105	Interferon alfa-2b	Interferon alpha/beta receptor 2	target
DB00105	Interferon alfa-2b	Interferon alpha/beta receptor 1	target
DB00105	Interferon alfa-2b	Cytochrome P450 1A2	enzyme
DB12688	Moxetumomab pasudotox	B-cell receptor CD22	target
DB12688	Moxetumomab pasudotox	Elongation factor 2	target
DB00552	Pentostatin	Adenosine deaminase	target

Drug	Drug Name	Phase	Status	Count
DB00316	Acetaminophen	1	Active Not Recruiting	1
DB00945	Acetylsalicylic acid	1	Active Not Recruiting	1
DB01234	Dexamethasone	1	Active Not Recruiting	1
DB01075	Diphenhydramine	1	Active Not Recruiting	1
DB00927	Famotidine	1	Active Not Recruiting	1
DB12688	Moxetumomab pasudotox	1	Active Not Recruiting	1
DB12688	Moxetumomab pasudotox	1	Completed	1
DB12688	Moxetumomab pasudotox	1	Unknown Status	1
DB16038	PLX8394	1	Terminated	1
DB12146	Rigosertib	1	Completed	1
DB00073	Rituximab	1	Active Not Recruiting	1
DB11703	Acalabrutinib	1 / 2	Active Not Recruiting	1
DB12121	Entospletinib	1 / 2	Completed	1
DB08935	Obinutuzumab	1 / 2	Completed	1
DB09037	Pembrolizumab	1 / 2	Active Not Recruiting	1
DB00316	Acetaminophen	2	Active Not Recruiting	1
DB06769	Bendamustine	2	Active Not Recruiting	1
DB11967	Binimetinib	2	Recruiting	2
DB00242	Cladribine	2	Active Not Recruiting	1
DB00242	Cladribine	2	Completed	1
DB00242	Cladribine	2	Recruiting	1
DB01075	Diphenhydramine	2	Active Not Recruiting	1
DB11718	Encorafenib	2	Recruiting	1
DB00668	Epinephrine	2	Active Not Recruiting	1
DB15223	Flotetuzumab	2	Withdrawn	1
DB09053	Ibrutinib	2	Active Not Recruiting	1
DB00034	Interferon alfa-2a	2	Completed	1
DB08935	Obinutuzumab	2	Active Not Recruiting	1
DB00552	Pentostatin	2	Active Not Recruiting	1
DB00073	Rituximab	2	Active Not Recruiting	2
DB00073	Rituximab	2	Completed	1
DB00073	Rituximab	2	Recruiting	2
DB08881	Vemurafenib	2	Active Not Recruiting	2
DB08881	Vemurafenib	2	Recruiting	1
DB00242	Cladribine	2 / 3	Recruiting	1
DB12688	Moxetumomab pasudotox	3	Completed	1
DB17366	MB-102 CD123 CAR	Not Available	Enrolling by Invitation	1