Active Secondary Progressive Multiple Sclerosis (SPMS)

Also known as: Active secondary progressive Multiple Sclerosis

DrugDrug NameDrug Description
DB08908Dimethyl fumarateA medication used to treat patients with the relapsing-remitting form of multiple sclerosis.
DB14783Diroximel fumarateA drug used for the treatment of relapsing forms of Multiple Sclerosis (MS).
DB08868FingolimodA sphingosine 1-phosphate receptor modulator used to treat patients with the relapsing-remitting form of multiple sclerosis (MS) and studied to manage lung complications of COVID-19.
DB05259GlatiramerAn immunomodulator used to reduce the frequency of relapses in Multiple Sclerosis (MS).
DB11988OcrelizumabA CD20 specific monoclonal antibody used to treat relapsing remitting multiple sclerosis.
DB06650OfatumumabAn anti-CD20 antibody used for the treatment of chronic lymphocytic leukemia (CLL) in selected patients with certain treatment histories and responsiveness to anticancer medications.
DB12612OzanimodA sphingosine 1-phosphate receptor modulator being studied to treat Multiple Sclerosis (MS) and inflammatory bowel disease (IBD).
DB12016PonesimodA sphingosine 1-phosphate receptor modulator indicated to treat relapsing multiple sclerosis.
DB11850UblituximabA low-fucose CD20-targeted monoclonal antibody used in the treatment of relapsing forms of multiple sclerosis.
DrugDrug NameTargetType
DB08908Dimethyl fumarateKelch-like ECH-associated protein 1target
DB08908Dimethyl fumarateTranscription factor p65target
DB14783Diroximel fumarateNeuronal acetylcholine receptor subunit alpha-10target
DB08868FingolimodSphingosine 1-phosphate receptor 5target
DB08868FingolimodSphingosine kinase 1enzyme
DB08868FingolimodCytochrome P450 2E1enzyme
DB08868FingolimodCytochrome P450 4F2enzyme
DB08868FingolimodHistone deacetylase 1target
DB08868FingolimodExcitatory amino acid transporter 2transporter
DB08868FingolimodExcitatory amino acid transporter 1transporter
DB08868FingolimodATP-dependent translocase ABCB1transporter
DB08868FingolimodMultidrug resistance-associated protein 1transporter
DB08868FingolimodSphingosine 1-phosphate receptor 1target
DB08868FingolimodSphingosine 1-phosphate receptor 4target
DB08868FingolimodSphingosine 1-phosphate receptor 3target
DB08868FingolimodD(3) dopamine receptortarget
DB08868FingolimodSphingosine kinase 1target
DB05259GlatiramerMHC class II protein complextarget
DB11988OcrelizumabB-lymphocyte antigen CD20target
DB06650OfatumumabB-lymphocyte antigen CD20target
DB12612OzanimodSphingosine 1-phosphate receptor 1target
DB12612OzanimodSphingosine 1-phosphate receptor 5target
DB12612OzanimodAmine oxidase [flavin-containing] Btransporter
DB12612OzanimodBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DB12612OzanimodATP-dependent translocase ABCB1transporter
DB12612OzanimodAldehyde dehydrogenase family 3 member A2enzyme
DB12612OzanimodAlcohol dehydrogenase class-3enzyme
DB12612OzanimodArylamine N-acetyltransferase 2enzyme
DB12612OzanimodCytochrome P450 2C8enzyme
DB12612OzanimodAmine oxidase [flavin-containing] Benzyme
DB12612OzanimodAldo-keto reductase family 1 member C1enzyme
DB12612OzanimodAldo-keto reductase family 1 member C2enzyme
DB12612OzanimodCytochrome P450 3A4enzyme
DB12016PonesimodSphingosine 1-phosphate receptor 1target
DB12016PonesimodCytochrome P450 2J2enzyme
DB12016PonesimodCytochrome P450 3A4enzyme
DB12016PonesimodCytochrome P450 3A5enzyme
DB12016PonesimodCytochrome P450 4F3enzyme
DB12016PonesimodCytochrome P450 4F12enzyme
DB12016PonesimodUDP-glucuronosyltransferase 1A1enzyme
DB12016PonesimodUDP-glucuronosyltransferase 2B7enzyme
DB11850UblituximabB-lymphocyte antigen CD20target
DrugDrug NamePhaseStatusCount