Advanced Renal Cell Carcinoma (aRCC)

Also known as: Advanced Renal Cell Cancer / Advanced Renal Cell Carcinoma (RCC) / Advanced Renal Cell Carcinoma / Adenocarcinoma of kidney / Renal cell cancer / Renal cell carcinoma stage unspecified / Grawitz tumor / Renal cell carcinoma NOS / Renal cell adenocarcinoma / Grawitz tumour / Renal cell carcinoma (disorder) / Renal cell carcinoma / Renal cell carcinoma (morphologic abnormality) / Carcinoma, Renal Cell / Clear cell carcinoma of kidney (disorder)

DrugDrug NameDrug Description
DB11945AvelumabAn anti-PD-L1 monoclonal antibody used to treat metastatic merkel cell carcinoma, metastatic urothelial carcinoma, or renal cell carcinoma.
DB06626AxitinibAn oral VEGFR and kinase inhibitor used for the treatment of advanced renal cell carcinoma after failure of one prior systemic therapy.
DB15463BelzutifanAn inhibitor of hypoxia-inducible factor 2α used as an antineoplastic in the treatment of certain cancers associated with von Hippel-Lindau (VHL) disease.
DB08875CabozantinibA tyrosine kinase inhibitor used to treat advanced renal cell carcinoma, hepatocellular carcinoma, and medullary thyroid cancer.
DB09078LenvatinibA receptor tyrosine kinase inhibitor used for the treatment of metastatic thyroid cancer, advanced renal cell carcinoma in combination with everolimus, and unresectable hepatocellular carcinoma.
DB09035NivolumabA PD-1 blocking antibody used to treat melanoma, non small-cell lung cancer, renal cell cancer, head and neck cancer, and Hodgkin lymphoma.
DB06589PazopanibAn antineoplastic agent used in the treatment of advanced renal cell cancer and advanced soft tissue sarcoma in patients with prior chemotherapy.
DB09037PembrolizumabA PD-1 blocking antibody used to treat various types of cancer, including metastatic melanoma, non small-cell lung cancer, cervical cancer, head and neck cancer, and Hodgkin's lymphoma.
DB00398SorafenibA kinase inhibitor used to treat unresectable liver carcinoma, advanced renal carcinoma, and differentiated thyroid carcinoma.
DB06287TemsirolimusA antineoplastic agent used in the treatment of renal cell carcinoma (RCC) that works by inhibiting mTOR.
DB11800TivozanibA kinase inhibitor to treat adult patients with renal cell carcinoma (RCC) who have failed prior systemic therapies or experienced relapsed disease.
DrugDrug NameTargetType
DB11945AvelumabProgrammed cell death 1 ligand 1target
DB06626AxitinibVascular endothelial growth factor receptor 1target
DB06626AxitinibVascular endothelial growth factor receptor 2target
DB06626AxitinibVascular endothelial growth factor receptor 3target
DB06626AxitinibCytochrome P450 3A4enzyme
DB06626AxitinibCytochrome P450 3A5enzyme
DB06626AxitinibCytochrome P450 1A2enzyme
DB06626AxitinibCytochrome P450 2C19enzyme
DB06626AxitinibUDP-glucuronosyltransferase 1A1enzyme
DB06626AxitinibATP-dependent translocase ABCB1transporter
DB06626AxitinibSolute carrier organic anion transporter family member 1B1transporter
DB06626AxitinibTyrosine-protein kinase ABL1target
DB15463BelzutifanEndothelial PAS domain-containing protein 1target
DB15463BelzutifanUDP-glucuronosyltransferase 2B17enzyme
DB15463BelzutifanCytochrome P450 2C19enzyme
DB15463BelzutifanCytochrome P450 3A4enzyme
DB15463BelzutifanATP-dependent translocase ABCB1transporter
DB15463BelzutifanSolute carrier organic anion transporter family member 1B1transporter
DB15463BelzutifanSolute carrier organic anion transporter family member 1B3transporter
DB15463BelzutifanMultidrug and toxin extrusion protein 2transporter
DB08875CabozantinibCytochrome P450 3A4enzyme
DB08875CabozantinibCytochrome P450 2C9enzyme
DB08875CabozantinibHepatocyte growth factor receptortarget
DB08875CabozantinibVascular endothelial growth factor receptor 2target
DB08875CabozantinibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB08875CabozantinibCytochrome P450 2C8enzyme
DB09078LenvatinibVascular endothelial growth factor receptor 1target
DB09078LenvatinibVascular endothelial growth factor receptor 2target
DB09078LenvatinibVascular endothelial growth factor receptor 3target
DB09078LenvatinibFibroblast growth factor receptor 1target
DB09078LenvatinibFibroblast growth factor receptor 2target
DB09078LenvatinibFibroblast growth factor receptor 3target
DB09078LenvatinibFibroblast growth factor receptor 4target
DB09078LenvatinibPlatelet-derived growth factor receptor alphatarget
DB09078LenvatinibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB09078LenvatinibMast/stem cell growth factor receptor Kittarget
DB09078LenvatinibATP-dependent translocase ABCB1transporter
DB09078LenvatinibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DB09078LenvatinibCytochrome P450 3A4enzyme
DB09078LenvatinibAldehyde oxidaseenzyme
DB09078LenvatinibCytochrome P450 2C8enzyme
DB09078LenvatinibCytochrome P450 2C9enzyme
DB09078LenvatinibCytochrome P450 1A2enzyme
DB09078LenvatinibCytochrome P450 2B6enzyme
DB09078LenvatinibCytochrome P450 2C19enzyme
DB09078LenvatinibSolute carrier family 22 member 6transporter
DB09078LenvatinibOrganic anion transporter 3transporter
DB09078LenvatinibSolute carrier family 22 member 2transporter
DB09078LenvatinibSolute carrier organic anion transporter family member 1B1transporter
DB09078LenvatinibBile salt export pumptransporter
DB09078LenvatinibCytochrome P450 2D6enzyme
DB09078LenvatinibSolute carrier organic anion transporter family member 1B3transporter
DB09035NivolumabProgrammed cell death protein 1target
DB09035NivolumabProgrammed cell death 1 ligand 1target
DB06589PazopanibVascular endothelial growth factor receptor 1target
DB06589PazopanibVascular endothelial growth factor receptor 2target
DB06589PazopanibVascular endothelial growth factor receptor 3target
DB06589PazopanibPlatelet-derived growth factor receptor alphatarget
DB06589PazopanibPlatelet-derived growth factor receptor betatarget
DB06589PazopanibMast/stem cell growth factor receptor Kittarget
DB06589PazopanibCytochrome P450 3A4enzyme
DB06589PazopanibCytochrome P450 2D6enzyme
DB06589PazopanibCytochrome P450 2C8enzyme
DB06589PazopanibCytochrome P450 1A2enzyme
DB06589PazopanibATP-dependent translocase ABCB1transporter
DB06589PazopanibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DB06589PazopanibSolute carrier organic anion transporter family member 1B1transporter
DB06589PazopanibUDP-glucuronosyltransferase 1A1transporter
DB06589PazopanibFibroblast growth factor receptor 3target
DB06589PazopanibTyrosine-protein kinase ITK/TSKtarget
DB06589PazopanibFibroblast growth factor 1target
DB06589PazopanibSH2B adapter protein 3target
DB09037PembrolizumabProgrammed cell death protein 1target
DB09037PembrolizumabProgrammed cell death 1 ligand 1target
DB00398SorafenibSerine/threonine-protein kinase B-raftarget
DB00398SorafenibReceptor-type tyrosine-protein kinase FLT3target
DB00398SorafenibRAF proto-oncogene serine/threonine-protein kinasetarget
DB00398SorafenibVascular endothelial growth factor receptor 3target
DB00398SorafenibPlatelet-derived growth factor receptor betatarget
DB00398SorafenibMast/stem cell growth factor receptor Kittarget
DB00398SorafenibVascular endothelial growth factor receptor 2target
DB00398SorafenibCytochrome P450 3A4enzyme
DB00398SorafenibUDP-glucuronosyltransferase 1A9enzyme
DB00398SorafenibCytochrome P450 2B6enzyme
DB00398SorafenibCytochrome P450 2C8enzyme
DB00398SorafenibCytochrome P450 3A5enzyme
DB00398SorafenibCytochrome P450 3A7enzyme
DB00398SorafenibCytochrome P450 2C9enzyme
DB00398SorafenibATP-binding cassette sub-family C member 4transporter
DB00398SorafenibATP-dependent translocase ABCB1transporter
DB00398SorafenibATP-binding cassette sub-family C member 2transporter
DB00398SorafenibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DB00398SorafenibCytochrome P450 1A2enzyme
DB00398SorafenibCytochrome P450 2C19enzyme
DB00398SorafenibCytochrome P450 2D6enzyme
DB00398SorafenibUDP-glucuronosyltransferase 1A1enzyme
DB00398SorafenibRalA-binding protein 1transporter
DB00398SorafenibFibroblast growth factor receptor 1target
DB00398SorafenibProto-oncogene tyrosine-protein kinase receptor Rettarget
DB00398SorafenibVascular endothelial growth factor receptor 1target
DB00398SorafenibSolute carrier organic anion transporter family member 1B1transporter
DB00398SorafenibEpidermal growth factor receptortarget
DB06287TemsirolimusSerine/threonine-protein kinase mTORtarget
DB06287TemsirolimusCytochrome P450 3A4enzyme
DB06287TemsirolimusCytochrome P450 3A5enzyme
DB06287TemsirolimusCytochrome P450 3A7enzyme
DB06287TemsirolimusCytochrome P450 2D6enzyme
DB06287TemsirolimusATP-dependent translocase ABCB1transporter
DB11800TivozanibCytochrome P450 3A4enzyme
DB11800TivozanibAlbumincarrier
DB11800TivozanibVascular endothelial growth factor receptor 1target
DB11800TivozanibVascular endothelial growth factor receptor 2target
DB11800TivozanibVascular endothelial growth factor receptor 3target
DB11800TivozanibMast/stem cell growth factor receptor Kittarget
DB11800TivozanibPlatelet-derived growth factor receptor betatarget
DB11800TivozanibATP-dependent translocase ABCB1transporter
DB11800TivozanibBroad substrate specificity ATP-binding cassette transporter ABCG2transporter
DB11800TivozanibReceptor-type tyrosine-protein kinase FLT3target
DB11800TivozanibPlatelet-derived growth factor receptor alphatarget
DB11800TivozanibProtein-tyrosine kinase 6target
DB11800TivozanibAngiopoietin-1 receptortarget
DB11800TivozanibFibroblast growth factor receptor 1target
DB11800TivozanibHepatocyte growth factor receptortarget
DrugDrug NamePhaseStatusCount
DB11945AvelumabNot AvailableCompleted1
DB06626AxitinibNot AvailableCompleted3
DB06186IpilimumabNot AvailableActive Not Recruiting1
DB09078LenvatinibNot AvailableActive Not Recruiting1
DB09035NivolumabNot AvailableActive Not Recruiting1
DB09037PembrolizumabNot AvailableActive Not Recruiting1
DB00398SorafenibNot AvailableCompleted2
DB01268SunitinibNot AvailableCompleted1
DB06287TemsirolimusNot AvailableCompleted1
DB00062Albumin human1Recruiting1
DB11595Atezolizumab1Recruiting1
DB06626Axitinib1Recruiting1
DB19248Bifidobacterium longum1Active Not Recruiting1
DB19248Bifidobacterium longum1Completed1
DB08875Cabozantinib1Active Not Recruiting2
DB08875Cabozantinib1Recruiting1
DB06091Evofosfamide1Unknown Status1
DB05304Girentuximab1Recruiting1
DB06186Ipilimumab1Completed1
DB06186Ipilimumab1Recruiting1
DB15823Lactobacillus acidophilus1Active Not Recruiting1
DB15823Lactobacillus acidophilus1Completed1
DB09078Lenvatinib1Recruiting1
DB13982Lutetium Lu-1771Recruiting1
DB09035Nivolumab1Active Not Recruiting2
DB09035Nivolumab1Completed1
DB09035Nivolumab1Recruiting1
DB01229Paclitaxel1Recruiting1
DB18893Volrustomig1Recruiting1
DB11595Atezolizumab1 / 2Recruiting1
DB11945Avelumab1 / 2Recruiting1
DB00531Cyclophosphamide1 / 2Recruiting1
DB11714Durvalumab1 / 2Recruiting1
DB01073Fludarabine1 / 2Recruiting1
DB17475Incomplete Freund's adjuvant1 / 2Unknown Status1
DB05258Interferon alfa1 / 2Completed1
DB09078Lenvatinib1 / 2Unknown Status1
DB15721Natural Killer Cell1 / 2Recruiting1
DB09035Nivolumab1 / 2Recruiting1
DB06589Pazopanib1 / 2Completed1
DB09037Pembrolizumab1 / 2Recruiting1
DB05992Plinabulin1 / 2Recruiting1
DB17562QL17061 / 2Unknown Status1
DB06626Axitinib2Terminated1
DB15676Balstilimab2Recruiting1
DB00112Bevacizumab2Completed1
DB16651Botensilimab2Recruiting1
DB08875Cabozantinib2Completed2
DB08875Cabozantinib2Recruiting1
DB14988Dalantercept2Terminated1
DB01070Dihydrotachysterol2Completed1
DB01590Everolimus2Terminated1
DB05304Girentuximab2Recruiting1
DB06186Ipilimumab2Active Not Recruiting1
DB06186Ipilimumab2Recruiting1
DB06186Ipilimumab2Terminated1
DB09078Lenvatinib2Terminated1
DB06080Linifanib2Completed1
DB13982Lutetium Lu-1772Recruiting1
DB09035Nivolumab2Active Not Recruiting1
DB09035Nivolumab2Recruiting3
DB09035Nivolumab2Terminated1
DB09073Palbociclib2Recruiting1
DB01269Panitumumab2Completed2
DB06589Pazopanib2Completed2
DB11972Rilotumumab2Completed1
DB00398Sorafenib2Completed2
DB01268Sunitinib2Completed2
DB15232Telaglenastat2Completed1
DB06287Temsirolimus2Completed1
DB12056Trebananib2Completed3
DB06626Axitinib2 / 3Recruiting1
DB01590Everolimus2 / 3Recruiting1
DB11679Fruquintinib2 / 3Recruiting1
DB15765Sintilimab2 / 3Recruiting1
DB06186Ipilimumab3Active Not Recruiting1
DB09035Nivolumab3Active Not Recruiting1
DB17588Rocapuldencel-T3Terminated1
DB00398Sorafenib3Completed2
DB01268Sunitinib3Active Not Recruiting1
DB01268Sunitinib3Terminated1
DB11800Tivozanib3Completed2