Membrane-associated progesterone receptor component 1

Details

Name
Membrane-associated progesterone receptor component 1
Synonyms
  • Dap1
  • HPR6.6
  • IZA
  • mPR
  • PGRMC
Gene Name
PGRMC1
UniProtKB Entry
O00264Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0008675|Membrane-associated progesterone receptor component 1
MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDD
EPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRD
ASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVY
SDEEEPKDESARKND
Number of residues
195
Molecular Weight
21670.9
Theoretical pI
Not Available
GO Classification
Functions
heme binding / steroid binding
Components
endoplasmic reticulum / membrane
General Function
Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed:30443021)
Specific Function
amyloid-beta binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
25-43
Cellular Location
Microsome membrane
Gene sequence
>lcl|BSEQ0020809|Membrane-associated progesterone receptor component 1 (PGRMC1)
ATGGCTGCCGAGGATGTGGTGGCGACTGGCGCCGACCCAAGCGATCTGGAGAGCGGCGGG
CTGCTGCATGAGATTTTCACGTCGCCGCTCAACCTGCTGCTGCTTGGCCTCTGCATCTTC
CTGCTCTACAAGATCGTGCGCGGGGACCAGCCGGCGGCCAGCGGCGACAGCGACGACGAC
GAGCCGCCCCCTCTGCCCCGCCTCAAGCGGCGCGACTTCACCCCCGCCGAGCTGCGGCGC
TTCGACGGCGTCCAGGACCCGCGCATACTCATGGCCATCAACGGCAAGGTGTTCGATGTG
ACCAAAGGCCGCAAATTCTACGGGCCCGTCAAGTATCATCACGTGGGCAAACTGCTGAAG
GAGGGGGAGGAGCCCACTGTGTACTCAGATGAGGAAGAACCAAAAGATGAGAGTGCCCGG
AAAAATGATTAA
Chromosome Location
X
Locus
Xq24
External Identifiers
ResourceLink
UniProtKB IDO00264
UniProtKB Entry NamePGRC1_HUMAN
GeneCard IDPGRMC1
HGNC IDHGNC:16090
PDB ID(s)4X8Y
KEGG IDhsa:10857
NCBI Gene ID10857
General References
  1. Gerdes D, Wehling M, Leube B, Falkenstein E: Cloning and tissue expression of two putative steroid membrane receptors. Biol Chem. 1998 Jul;379(7):907-11. [Article]
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Associated Data

Bio-Entities
Bio-EntityType
Membrane-associated progesterone receptor component 1 (Humans)protein
primary
Sigma receptor (Humans)protein
Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
DextromethorphanapprovedunknowntargetbinderDetails
NortriptylineapprovedunknowntargetbinderDetails
SertralineapprovedunknowntargetinhibitorbinderDetails