Cytochrome c oxidase subunit NDUFA4
Details
- Name
- Cytochrome c oxidase subunit NDUFA4
- Synonyms
- CI-MLRQ
- Complex I-MLRQ
- NADH-ubiquinone oxidoreductase MLRQ subunit
- Gene Name
- NDUFA4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0016024|Cytochrome c oxidase subunit NDUFA4 MLRQIIGQAKKHPSLIPLFVFIGTGATGATLYLLRLALFNPDVCWDRNNPEPWNKLGPND QYKFYSVNVDYSKLKKERPDF
- Number of residues
- 81
- Molecular Weight
- 9369.78
- Theoretical pI
- 9.84
- GO Classification
- FunctionsNADH dehydrogenase (ubiquinone) activity / protein complex bindingProcessescellular metabolic process / hydrogen ion transmembrane transport / mitochondrial electron transport, NADH to ubiquinone / respiratory electron transport chain / small molecule metabolic processComponentsextracellular exosome / mitochondrial inner membrane / mitochondrial respiratory chain complex I / mitochondrial respiratory chain complex IV / mitochondrion
- General Function
- Protein complex binding
- Specific Function
- Cytochrome c oxidase (COX, complex IV) is the terminal component of the mitochondrial respiratory chain that catalyzes the reduction of oxygen to water. Required for complex IV maintenance.
- Pfam Domain Function
- B12D (PF06522)
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion inner membrane
- Gene sequence
>lcl|BSEQ0016025|Cytochrome c oxidase subunit NDUFA4 (NDUFA4) ATGCTCCGCCAGATCATCGGTCAGGCCAAGAAGCATCCGAGCTTGATCCCCCTCTTTGTA TTTATTGGAACTGGAGCTACTGGAGCAACACTGTATCTCTTGCGTCTGGCATTGTTCAAT CCAGATGTTTGTTGGGACAGAAATAACCCAGAGCCCTGGAACAAACTGGGTCCCAATGAT CAATACAAGTTCTACTCAGTGAATGTGGATTACAGCAAGCTGAAGAAGGAACGTCCAGAT TTCTAA
- Chromosome Location
- 7
- Locus
- 7p21.3
- External Identifiers
Resource Link UniProtKB ID O00483 UniProtKB Entry Name NDUA4_HUMAN GenBank Protein ID 1946692 GenBank Gene ID U94586 GenAtlas ID NDUFA4 HGNC ID HGNC:7687 - General References
- Kim JW, Lee Y, Kang HB, Chose YK, Chung TW, Chang SY, Lee KS, Choe IS: Cloning of the human cDNA sequence encoding the NADH:ubiquinone oxidoreductase MLRQ subunit. Biochem Mol Biol Int. 1997 Oct;43(3):669-75. [Article]
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- Murray J, Zhang B, Taylor SW, Oglesbee D, Fahy E, Marusich MF, Ghosh SS, Capaldi RA: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. J Biol Chem. 2003 Apr 18;278(16):13619-22. Epub 2003 Feb 28. [Article]
- Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]
- Balsa E, Marco R, Perales-Clemente E, Szklarczyk R, Calvo E, Landazuri MO, Enriquez JA: NDUFA4 is a subunit of complex IV of the mammalian electron transport chain. Cell Metab. 2012 Sep 5;16(3):378-86. doi: 10.1016/j.cmet.2012.07.015. Epub 2012 Aug 16. [Article]
- Pitceathly RD, Rahman S, Wedatilake Y, Polke JM, Cirak S, Foley AR, Sailer A, Hurles ME, Stalker J, Hargreaves I, Woodward CE, Sweeney MG, Muntoni F, Houlden H, Taanman JW, Hanna MG: NDUFA4 mutations underlie dysfunction of a cytochrome c oxidase subunit linked to human neurological disease. Cell Rep. 2013 Jun 27;3(6):1795-805. doi: 10.1016/j.celrep.2013.05.005. Epub 2013 Jun 6. [Article]
- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
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