SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
Details
- Name
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
- Synonyms
- 3.6.4.-
- hSNF2H
- SNF2H
- Sucrose nonfermenting protein 2 homolog
- SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5
- WCRF135
- Gene Name
- SMARCA5
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0019595|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 MSSAAEPPPPPPPESAPSKPAASIASGGSNSSNKGGPEGVAAQAVASAASAGPADAEMEE IFDDASPGKQKEIQEPDPTYEEKMQTDRANRFEYLLKQTELFAHFIQPAAQKTPTSPLKM KPGRPRIKKDEKQNLLSVGDYRHRRTEQEEDEELLTESSKATNVCTRFEDSPSYVKWGKL RDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKST LHNWMSEFKRWVPTLRSVCLIGDKEQRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKF NWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVFN SADDFDSWFDTNNCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKMQ REWYTRILMKDIDILNSAGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDMHLVT NSGKMVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQD SINAYNEPNSTKFVFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQTK TVRVFRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVDQNLNKIGKDEMLQMIRHGATH VFASKESEITDEDIDGILERGAKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYR EKQKIAFTEWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPR LFELLEKEILFYRKTIGYKVPRNPELPNAAQAQKEEQLKIDEAESLNDEELEEKEKLLTQ GFTNWNKRDFNQFIKANEKWGRDDIENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKI MAQIERGEARIQRRISIKKALDTKIGRYKAPFHQLRISYGTNKGKNYTEEEDRFLICMLH KLGFDKENVYDELRQCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENMELEEKEK AEKKKRGPKPSTQKRKMDGAPDGRGRKKKLKL
- Number of residues
- 1052
- Molecular Weight
- 121904.335
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / ATPase activity / DNA binding / helicase activityProcessesATP-dependent chromatin remodeling / CENP-A containing nucleosome assembly / chromatin remodeling / chromatin silencing at rDNA / DNA repair / DNA-templated transcription, initiation / double-strand break repair / gene expression / negative regulation of gene expression, epigenetic / nucleosome assembly / nucleosome positioning / regulation of gene expression, epigenetic / regulation of transcription from RNA polymerase II promoterComponentschromatin silencing complex / condensed chromosome / nucleolus / nucleoplasm / nucleus / NURF complex / RSF complex
- General Function
- Helicase activity
- Specific Function
- Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0019596|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) ATGTCGTCCGCGGCCGAGCCTCCGCCACCCCCGCCTCCCGAGAGCGCGCCTTCCAAGCCC GCAGCCTCGATCGCCAGCGGCGGGAGCAACAGCAGCAACAAAGGCGGCCCCGAAGGCGTC GCGGCGCAGGCGGTTGCGTCTGCGGCCAGCGCTGGTCCCGCAGACGCCGAGATGGAGGAA ATATTTGATGATGCGTCACCTGGAAAGCAAAAGGAAATCCAAGAACCAGATCCTACCTAT GAAGAAAAAATGCAAACTGACCGGGCAAATAGATTCGAGTATTTATTAAAGCAGACAGAA CTTTTTGCACATTTCATTCAACCTGCTGCTCAGAAGACTCCAACTTCACCTTTGAAGATG AAACCAGGGCGCCCACGAATAAAAAAAGATGAGAAGCAGAACTTACTATCCGTTGGCGAT TACCGACACCGTAGAACAGAGCAAGAGGAGGATGAAGAGCTATTAACAGAAAGCTCCAAA GCAACCAATGTTTGCACTCGATTTGAAGACTCTCCATCGTATGTAAAATGGGGTAAACTG AGAGATTATCAGGTCCGAGGATTAAACTGGCTCATTTCTTTGTATGAGAATGGCATCAAT GGTATCCTTGCAGATGAAATGGGCCTAGGAAAGACTCTTCAAACAATTTCTCTTCTTGGG TACATGAAACATTATAGAAACATTCCTGGGCCTCATATGGTTTTGGTTCCTAAGTCTACA TTACACAACTGGATGAGTGAATTCAAGAGATGGGTACCAACACTTAGATCTGTTTGTTTG ATAGGAGATAAAGAACAAAGAGCTGCTTTTGTCAGAGACGTTTTATTACCGGGAGAATGG GATGTATGTGTAACATCTTATGAAATGCTTATTAAAGAGAAGTCTGTGTTCAAAAAATTT AATTGGAGATACTTAGTAATAGATGAAGCTCACAGGATCAAAAATGAAAAATCTAAGTTG TCAGAAATAGTGAGGGAATTCAAGACTACAAATAGACTATTATTAACTGGAACACCTCTT CAGAACAACTTGCATGAGCTGTGGTCACTTCTTAACTTTCTGTTGCCAGATGTGTTTAAT TCAGCAGATGACTTTGATTCCTGGTTTGATACAAACAACTGCCTTGGGGATCAAAAACTA GTTGAGAGGCTTCATATGGTTTTGCGTCCATTCCTCCTTCGTCGAATTAAGGCTGATGTT GAAAAGAGTTTGCCTCCAAAGAAGGAAGTAAAAATCTATGTGGGCCTCAGCAAAATGCAA AGGGAATGGTATACTCGGATATTAATGAAGGATATAGATATACTCAACTCAGCAGGCAAG ATGGACAAAATGAGGTTATTGAACATCCTAATGCAGTTGAGAAAATGTTGTAATCATCCA TATCTCTTTGATGGAGCAGAACCTGGTCCACCTTATACAACAGATATGCATCTAGTAACC AACAGTGGCAAAATGGTGGTTTTAGACAAGCTGCTCCCTAAGTTAAAAGAACAAGGTTCA CGAGTACTAATCTTCAGTCAAATGACAAGGGTATTGGACATTTTGGAAGATTATTGCATG TGGAGAAATTATGAGTACTGCAGGTTGGATGGTCAGACACCCCATGATGAGAGACAAGAC TCCATCAATGCATACAATGAACCAAACAGCACAAAGTTTGTTTTCATGTTAAGCACGCGT GCTGGTGGTCTTGGCATCAATCTTGCGACTGCTGATGTAGTAATTTTGTATGATTCTGAT TGGAATCCCCAAGTAGATCTTCAGGCTATGGACCGAGCACATAGAATTGGGCAGACTAAG ACAGTCAGAGTGTTCCGCTTTATAACTGATAACACTGTAGAAGAAAGAATAGTAGAACGT GCTGAGATGAAACTCAGACTGGATTCAATAGTCATTCAACAAGGGAGGCTTGTGGATCAG AATCTGAACAAAATTGGGAAAGATGAAATGCTTCAAATGATTAGACATGGAGCAACACAT GTGTTTGCTTCAAAGGAAAGTGAGATCACTGATGAAGATATCGATGGTATTTTGGAAAGA GGTGCAAAGAAGACTGCAGAGATGAATGAAAAGCTCTCCAAGATGGGCGAAAGTTCACTT AGAAACTTTACAATGGATACAGAGTCAAGTGTTTATAACTTCGAAGGAGAAGACTATAGA GAAAAACAAAAGATTGCATTCACAGAGTGGATTGAACCACCTAAACGAGAAAGAAAAGCC AACTATGCCGTTGATGCATATTTCAGGGAAGCTCTTCGTGTTAGTGAACCTAAAGCACCC AAGGCTCCTCGACCTCCAAAACAACCCAATGTTCAGGATTTCCAGTTCTTTCCTCCACGT TTATTTGAATTACTGGAAAAAGAAATTCTGTTTTACAGAAAAACTATTGGGTACAAGGTA CCTCGAAATCCTGAGCTGCCTAACGCAGCACAGGCACAAAAAGAAGAACAGCTTAAAATT GATGAAGCTGAATCCCTTAATGATGAAGAGTTAGAGGAAAAAGAGAAGCTTCTAACACAG GGATTTACCAATTGGAATAAGAGAGATTTTAACCAGTTTATCAAAGCTAATGAGAAGTGG GGTCGTGATGATATTGAAAATATAGCAAGAGAAGTAGAAGGCAAAACTCCAGAAGAAGTC ATTGAATATTCAGCTGTGTTTTGGGAAAGGTGCAACGAGCTCCAGGACATAGAGAAGATT ATGGCTCAGATTGAAAGGGGAGAGGCGAGAATTCAAAGAAGAATAAGCATCAAGAAAGCA CTTGACACAAAGATTGGACGGTACAAAGCACCTTTTCATCAGCTGAGAATATCATATGGT ACTAACAAAGGAAAAAACTATACTGAAGAAGAAGATCGTTTTCTGATTTGTATGCTTCAC AAACTTGGATTTGACAAAGAAAATGTTTATGATGAATTGCGACAGTGTATTCGCAACTCT CCTCAGTTCAGATTTGACTGGTTTCTTAAGTCCAGAACTGCAATGGAGCTCCAGAGGAGA TGTAATACCTTAATTACTTTGATTGAAAGAGAAAACATGGAACTAGAAGAAAAGGAGAAG GCAGAGAAAAAGAAACGAGGACCAAAGCCTTCAACACAGAAACGTAAAATGGATGGCGCA CCTGATGGTCGAGGAAGAAAAAAGAAGCTGAAACTATGA
- Chromosome Location
- 4
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O60264 UniProtKB Entry Name SMCA5_HUMAN HGNC ID HGNC:11101 - General References
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