Receptor activity-modifying protein 1
Details
- Name
- Receptor activity-modifying protein 1
- Synonyms
- Calcitonin-receptor-like receptor activity-modifying protein 1
- CRLR activity-modifying protein 1
- Gene Name
- RAMP1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010607|Receptor activity-modifying protein 1 MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWG RTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILY PFIVVPITVTLLVTALVVWQSKRTEGIV
- Number of residues
- 148
- Molecular Weight
- 16987.765
- Theoretical pI
- 8.29
- GO Classification
- Functionscalcitonin receptor activity / calcitonin receptor binding / coreceptor activity / protein transporter activity / receptor activityProcessesangiogenesis / calcium ion transport / cellular response to hormone stimulus / intracellular protein transport / positive regulation of cAMP biosynthetic process / positive regulation of protein glycosylation / protein localization to plasma membrane / protein transport / receptor internalization / regulation of G-protein coupled receptor protein signaling pathwayComponentscell surface / extracellular space / integral component of plasma membrane / intracellular / plasma membrane / receptor complex
- General Function
- Receptor activity
- Specific Function
- Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.
- Pfam Domain Function
- RAMP (PF04901)
- Transmembrane Regions
- 118-138
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0001711|447 bp ATGGCCCGGGCCCTGTGCCGCCTCCCGCGGCGCGGCCTCTGGCTGCTCCTGGCCCATCAC CTCTTCATGACCACTGCCTGCCAGGAGGCTAACTACGGTGCCCTCCTCCGGGAGCTCTGC CTCACCCAGTTCCAGGTAGACATGGAGGCCGTCGGGGAGACGCTGTGGTGTGACTGGGGC AGGACCATCAGGAGCTACAGGGAGCTGGCCGACTGCACCTGGCACATGGCGGAGAAGCTG GGCTGCTTCTGGCCCAATGCAGAGGTGGACAGGTTCTTCCTGGCAGTGCATGGCCGCTAC TTCAGGAGCTGCCCCATCTCAGGCAGGGCCGTGCGGGACCCGCCCGGCAGCATCCTCTAC CCCTTCATCGTGGTCCCCATCACGGTGACCCTGCTGGTGACGGCACTGGTGGTCTGGCAG AGCAAGCGCACTGAGGGCATTGTGTAG
- Chromosome Location
- Not Available
- Locus
- 2q36-q37.1
- External Identifiers
Resource Link UniProtKB ID O60894 UniProtKB Entry Name RAMP1_HUMAN GenBank Protein ID 3171910 GenBank Gene ID AJ001014 GenAtlas ID RAMP1 HGNC ID HGNC:9843 - General References
- McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM: RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 1998 May 28;393(6683):333-9. [Article]
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- Kusano S, Kukimoto-Niino M, Akasaka R, Toyama M, Terada T, Shirouzu M, Shindo T, Yokoyama S: Crystal structure of the human receptor activity-modifying protein 1 extracellular domain. Protein Sci. 2008 Nov;17(11):1907-14. doi: 10.1110/ps.036012.108. Epub 2008 Aug 25. [Article]
- ter Haar E, Koth CM, Abdul-Manan N, Swenson L, Coll JT, Lippke JA, Lepre CA, Garcia-Guzman M, Moore JM: Crystal structure of the ectodomain complex of the CGRP receptor, a class-B GPCR, reveals the site of drug antagonism. Structure. 2010 Sep 8;18(9):1083-93. doi: 10.1016/j.str.2010.05.014. [Article]