Retinal dehydrogenase 2
Details
- Name
- Retinal dehydrogenase 2
- Synonyms
- 1.2.1.36
- Aldehyde dehydrogenase family 1 member A2
- RALDH 2
- RALDH(II)
- RALDH2
- Retinaldehyde-specific dehydrogenase type 2
- Gene Name
- ALDH1A2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001024|Retinal dehydrogenase 2 MTSSKIEMPGEVKADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNP ATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVL ATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVC GQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILP GYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADAD LDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQG PQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFG PVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQ SPFGGFKMSGNGREMGEFGLREYSEVKTVTVKIPQKNS
- Number of residues
- 518
- Molecular Weight
- 56723.495
- Theoretical pI
- 5.84
- GO Classification
- Functions3-chloroallyl aldehyde dehydrogenase activity / aldehyde dehydrogenase (NAD) activity / retinal binding / retinal dehydrogenase activityProcesses9-cis-retinoic acid biosynthetic process / anterior/posterior pattern specification / blood vessel development / cardiac muscle tissue development / cellular response to retinoic acid / determination of bilateral symmetry / embryonic camera-type eye development / embryonic digestive tract development / embryonic forelimb morphogenesis / face development / heart morphogenesis / hindbrain development / kidney development / liver development / lung development / midgut development / morphogenesis of embryonic epithelium / negative regulation of cell proliferation / neural crest cell development / neural tube development / neuron differentiation / pancreas development / pituitary gland development / positive regulation of apoptotic process / positive regulation of cell proliferation / positive regulation of gene expression / proximal/distal pattern formation / regulation of endothelial cell proliferation / response to cytokine / response to estradiol / response to vitamin A / retinal metabolic process / retinoic acid metabolic process / retinoic acid receptor signaling pathway / retinol metabolic process / ureter maturation / vitamin A metabolic processComponentscytoplasm / cytosol / perinuclear region of cytoplasm
- General Function
- Retinal dehydrogenase activity
- Specific Function
- Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity).
- Pfam Domain Function
- Aldedh (PF00171)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0016114|Retinal dehydrogenase 2 (ALDH1A2) ATGAAGAATCAGTGTGAGACTGTTTGGTTAAAATCCCCAATAAAACTGAAACTGATCTTT ATAAACAACGAGTGGCAGAACTCAGAGAGTGGGAGAGTGTTCCCTGTCTATAATCCAGCC ACAGGAGAACAGGTGTGTGAAGTTCAAGAAGCAGACAAGGCAGATATAGACAAAGCAGTG CAGGCAGCCCGCCTGGCTTTCTCTCTTGGTTCAGTGTGGAGAAGGATGGATGCTTCAGAA AGGGGACGTCTGTTGGATAAGCTTGCAGACTTGGTGGAACGGGACAGGGCAGTTCTTGCA ACCATGGAATCCCTAAATGGTGGCAAACCATTCCTGCAAGCTTTTTATGTGGATTTGCAG GGCGTCATCAAAACCTTTCGATATTACGCAGGCTGGGCTGATAAAATTCATGGGATGACC ATTCCTGTAGATGGAGACTATTTTACCTTTACAAGACATGAACCCATTGGAGTGTGTGGA CAGATCATCCCATGGAACTTCCCCCTGCTGATGTTTGCCTGGAAAATAGCTCCAGCTTTG TGCTGTGGCAATACAGTAGTTATTAAGCCAGCAGAGCAAACACCACTCAGTGCACTCTAC ATGGGAGCCCTCATCAAGGAGGCTGGCTTTCCTCCCGGGGTCATCAATATTTTGCCAGGA TATGGGCCAACGGCTGGGGCAGCAATAGCTTCTCACATTGGCATAGACAAGATTGCATTC ACAGGGTCTACTGAGGTTGGAAAGCTTATCCAAGAAGCAGCTGGAAGAAGTAATTTGAAG AGAGTAACTCTGGAACTTGGAGGCAAAAGTCCTAATATTATTTTTGCTGATGCTGACTTG GACTATGCTGTGGAGCAGGCCCACCAGGGTGTGTTCTTCAATCAAGGTCAGTGCTGCACT GCAGGCTCTCGCATCTTCGTGGAGGAGTCCATCTATGAGGAGTTTGTGAGAAGAAGCGTG GAGCGGGCCAAGAGGCGCGTAGTGGGGAGTCCCTTTGACCCCACCACTGAGCAGGGTCCC CAGATTGATAAGAAACAGTACAACAAGATCTTGGAACTCATCCAGAGTGGTGTGGCTGAG GGCGCCAAGCTGGAATGTGGAGGCAAAGGACTGGGCCGAAAGGGGTTTTTCATTGAGCCC ACAGTGTTTTCCAACGTCACTGATGATATGCGGATTGCCAAGGAGGAGATCTTTGGCCCT GTTCAGGAAATTTTGAGATTTAAGACGATGGATGAAGTTATCGAAAGAGCCAATAACTCA GACTTTGGACTCGTAGCAGCTGTCTTTACTAATGACATCAACAAGGCCCTCACAGTGTCT TCTGCAATGCAAGCTGGGACTGTTTGGATCAATTGTTACAATGCCTTAAATGCCCAGAGC CCCTTTGGGGGATTCAAGATGTCTGGAAATGGGAGAGAAATGGGAGAATTTGGCTTGCGG GAGTACTCAGAAGTTAAGACGGTGACAGTAAAGATCCCCCAGAAGAACTCCTAA
- Chromosome Location
- 15
- Locus
- 15q22.1
- External Identifiers
Resource Link UniProtKB ID O94788 UniProtKB Entry Name AL1A2_HUMAN GenBank Protein ID 3970842 GenBank Gene ID AB015226 GenAtlas ID ALDH1A2 HGNC ID HGNC:15472 - General References
- Ono Y, Fukuhara N, Yoshie O: TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol Cell Biol. 1998 Dec;18(12):6939-50. [Article]
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