Growth/differentiation factor 11

Details

Name

Growth/differentiation factor 11

Synonyms

• BMP-11
• BMP11
• Bone morphogenetic protein 11
• GDF-11

Gene Name

GDF11

UniProtKB Entry

O95390Swiss-Prot

Organism

Humans

NCBI Taxonomy ID

9606

Amino acid sequence

>lcl|BSEQ0053856|Growth/differentiation factor 11
MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAAAGVGGERSSRPAPSVAPEPD
GCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQ
GDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQL
WVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDF
KQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNL
GLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQ
QANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS

Number of residues

407

Molecular Weight

45090.36

Theoretical pI

Not Available

GO Classification

Functions

cytokine activity / growth factor activity

Processes

amacrine cell differentiation / camera-type eye morphogenesis / cell population proliferation / mesoderm development / metanephros development / negative regulation of amacrine cell differentiation / negative regulation of cell population proliferation / nervous system development / roof of mouth development / skeletal system development / SMAD protein signal transduction / spinal cord anterior/posterior patterning / type B pancreatic cell maturation / ureteric bud development

Components

extracellular space / intracellular membrane-bounded organelle / nucleoplasm / protein-containing complex

General Function

Secreted signal that acts globally to regulate anterior/posterior axial patterning during development. May play critical roles in patterning both mesodermal and neural tissues (By similarity). It is required for proper vertebral patterning and orofacial development (PubMed:31215115). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634)

Specific Function

cytokine activity

Pfam Domain Function

• TGF_beta (PF00019)
• TGFb_propeptide (PF00688)

Signal Regions

1-24

Transmembrane Regions

Not Available

Cellular Location

Secreted

Gene sequence

>lcl|BSEQ0053857|Growth/differentiation factor 11 (GDF11)
ATGGTGCTCGCGGCCCCGCTGCTGCTGGGCTTCCTGCTCCTCGCCCTGGAGCTGCGGCCC
CGGGGGGAGGCGGCCGAGGGCCCCGCGGCGGCGGCGGCGGCGGCGGCGGCGGCGGCAGCG
GCGGGGGTCGGGGGGGAGCGCTCCAGCCGGCCAGCCCCGTCCGTGGCGCCCGAGCCGGAC
GGCTGCCCCGTGTGCGTTTGGCGGCAGCACAGCCGCGAGCTGCGCCTAGAGAGCATCAAG
TCGCAGATCTTGAGCAAACTGCGGCTCAAGGAGGCGCCCAACATCAGCCGCGAGGTGGTG
AAGCAGCTGCTGCCCAAGGCGCCGCCGCTGCAGCAGATCCTGGACCTACACGACTTCCAG
GGCGACGCGCTGCAGCCCGAGGACTTCCTGGAGGAGGACGAGTACCACGCCACCACCGAG
ACCGTCATTAGCATGGCCCAGGAGACGGACCCAGCAGTACAGACAGATGGCAGCCCTCTC
TGCTGCCATTTTCACTTCAGCCCCAAGGTGATGTTCACAAAGGTACTGAAGGCCCAGCTG
TGGGTGTACCTACGGCCTGTACCCCGCCCAGCCACAGTCTACCTGCAGATCTTGCGACTA
AAACCCCTAACTGGGGAAGGGACCGCAGGGGGAGGGGGCGGAGGCCGGCGTCACATCCGT
ATCCGCTCACTGAAGATTGAGCTGCACTCACGCTCAGGCCATTGGCAGAGCATCGACTTC
AAGCAAGTGCTACACAGCTGGTTCCGCCAGCCACAGAGCAACTGGGGCATCGAGATCAAC
GCCTTTGATCCCAGTGGCACAGACCTGGCTGTCACCTCCCTGGGGCCGGGAGCCGAGGGG
CTGCATCCATTCATGGAGCTTCGAGTCCTAGAGAACACAAAACGTTCCCGGCGGAACCTG
GGTCTGGACTGCGACGAGCACTCAAGCGAGTCCCGCTGCTGCCGATATCCCCTCACAGTG
GACTTTGAGGCTTTCGGCTGGGACTGGATCATCGCACCTAAGCGCTACAAGGCCAACTAC
TGCTCCGGCCAGTGCGAGTACATGTTCATGCAAAAATATCCGCATACCCATTTGGTGCAG
CAGGCCAATCCAAGAGGCTCTGCTGGGCCCTGTTGTACCCCCACCAAGATGTCCCCAATC
AACATGCTCTACTTCAATGACAAGCAGCAGATTATCTACGGCAAGATCCCTGGCATGGTG
GTGGATCGCTGTGGCTGCTCTTAA

Chromosome Location

12

Locus

12q13.2

External Identifiers

Resource	Link
UniProtKB ID	O95390
UniProtKB Entry Name	GDF11_HUMAN
GeneCard ID	GDF11
HGNC ID	HGNC:4216
PDB ID(s)	5E4G, 5JHW, 5UHM, 6MAC, 7MRZ
KEGG ID	hsa:10220
NCBI Gene ID	10220

General References

Not Available

Associated Data

Bio-Entities

Bio-Entity	Type
Growth/differentiation factor 11 (Humans)	protein primary

Drug Relations

Drug	Drug group	Pharmacological action?	Type	Actions	Details
Sotatercept	approved, investigational	yes	target	binder	Details