Thymidylate synthase
Details
- Name
- Thymidylate synthase
- Synonyms
- 2.1.1.45
- TS
- Gene Name
- thyA
- Organism
- Lactobacillus casei
- Amino acid sequence
>lcl|BSEQ0002980|Thymidylate synthase MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSE LLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHE EMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRL IVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLV AHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIK LLNYDPYPAIKAPVAV
- Number of residues
- 316
- Molecular Weight
- 36579.235
- Theoretical pI
- 6.28
- GO Classification
- Functionsthymidylate synthase activityProcessesdTMP biosynthetic process / dTTP biosynthetic processComponentscytoplasm
- General Function
- Thymidylate synthase activity
- Specific Function
- Provides the sole de novo source of dTMP for DNA biosynthesis.
- Pfam Domain Function
- Thymidylat_synt (PF00303)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0002979|990 bp ATGTGTCGAGTAGTGAACGGTAAAGGAGCAGAGCAGACAATGTTAGAACAGCCATATCTT GATCTTGCAAAAAAAGTTCTGGATGAAGGCCATTTCAAGCCTGATCGGACCCATACAGGA ACTTACAGTATTTTCGGCCACCAAATGCGTTTCGACCTTAGCAAGGGCTTTCCATTACTG ACGACCAAAAAAGTACCATTCGGCCTTATTAAGAGTGAGTTGTTGTGGTTTTTACACGGT GATACCAACATTCGGTTCTTACTCCAACACAGGAATCACATTTGGGATGAGTGGGCGTTT GAAAAATGGGTGAAGAGTGATGAATATCACGGCCCGGACATGACTGATTTTGGGCATCGC AGCCAAAAGGATCCGGAATTCGCGGCAGTTTATCATGAAGAAATGGCTAAATTCGATGAC CGGGTGCTTCATGATGATGCTTTTGCAGCCAAATATGGTGATCTTGGCTTGGTTTATGGA TCCCAATGGCGGGCCTGGCATACGAGCAAGGGTGACACGATCGACCAGTTGGGGGACGTT ATTGAGCAAATCAAAACGCATCCCTATTCACGACGGCTCATCGTGTCGGCGTGGAATCCG GAAGATGTCCCGACAATGGCGCTACCGCCTTGTCACACGCTCTATCAGTTTTATGTCAAT GATGGCAAGCTGTCTTTGCAGTTGTACCAACGTTCGGCTGACATTTTTCTTGGCGTCCCG TTTAATATCGCGTCCTATGCGTTGTTAACGCATCTGGTCGCGCATGAATGTGGCCTTGAA GTTGGCGAATTCATTCATACATTCGGCGATGCGCATCTTTACGTCAATCATCTTGACCAA ATTAAAGAGCAGCTCAGTCGCACGCCGCGGCCGGCACCGACTTTACAGTTGAATCCGGAT AAACATGATATTTTCGACTTTGACATGAAGGATATTAAGTTGCTTAATTACGATCCTTAT CCGGCCATTAAGGCACCGGTTGCCGTTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P00469 UniProtKB Entry Name TYSY_LACCA GenBank Protein ID 149601 GenBank Gene ID M19653 - General References
- Pinter K, Davisson VJ, Santi DV: Cloning, sequencing, and expression of the Lactobacillus casei thymidylate synthase gene. DNA. 1988 May;7(4):235-41. [Article]
- Maley GF, Bellisario RL, Guarino DU, Maley F: The primary structure of Lactobacillus casei thymidylate synthetase. III. The use of 2-(2-nitrophenylsulfenyl)-3-methyl-3-bromoindolenine and limited tryptic peptides to establish the complete amino acid sequence of the enzyme. J Biol Chem. 1979 Feb 25;254(4):1301-4. [Article]
- Perry KM, Fauman EB, Finer-Moore JS, Montfort WR, Maley GF, Maley F, Stroud RM: Plastic adaptation toward mutations in proteins: structural comparison of thymidylate synthases. Proteins. 1990;8(4):315-33. [Article]
- Finer-Moore J, Fauman EB, Foster PG, Perry KM, Santi DV, Stroud RM: Refined structures of substrate-bound and phosphate-bound thymidylate synthase from Lactobacillus casei. J Mol Biol. 1993 Aug 20;232(4):1101-16. [Article]
- Kealey JT, Eckstein J, Santi DV: Role of the conserved tryptophan 82 of Lactobacillus casei thymidylate synthase. Chem Biol. 1995 Sep;2(9):609-14. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02301 5,10-Methylene-6-Hydrofolic Acid experimental unknown Details DB03541 10-Propargyl-5,8-Dideazafolic Acid experimental unknown Details DB03685 Uridine monophosphate experimental unknown Details DB03761 5-fluoro-2'-deoxyuridine-5'-monophosphate experimental unknown Details DB03798 2'-Deoxycytidine-5'-Monophosphate experimental unknown Details DB03800 Deoxyuridine monophosphate experimental unknown Details DB01643 Thymidine monophosphate experimental unknown product of Details DB06860 2-(2-chloropyridin-4-yl)-4-methyl-1H-isoindole-1,3(2H)-dione experimental unknown Details DB07507 2-(4-hydroxybiphenyl-3-yl)-4-methyl-1H-isoindole-1,3(2H)-dione experimental unknown Details DB07511 4-(4-methyl-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)benzonitrile experimental unknown Details DB08204 3-DIPHENOL-6-NITRO-3H-BENZO[DE]ISOCHROMEN-1-ONE experimental unknown Details