Alpha-lytic protease
Details
- Name
- Alpha-lytic protease
- Synonyms
- 3.4.21.12
- Alpha-lytic endopeptidase
- Gene Name
- alpha-LP
- Organism
- Lysobacter enzymogenes
- Amino acid sequence
>lcl|BSEQ0011418|Alpha-lytic protease MYVSNHRSRRVARVSVSCLVAALAAMSCGAALAADQVDPQLKFAMQRDLGIFPTQLPQYL QTEKLARTQAAAIEREFGAQFAGSWIERNEDGSFKLVAATSGARKSSTLGGVEVRNVRYS LKQLQSAMEQLDAGANARVKGVSKPLDGVQSWYVDPRSNAVVVKVDDGATEAGVDFVALS GADSAQVRIESSPGKLQTTANIVGGIEYSINNASLCSVGFSVTRGATKGFVTAGHCGTVN ATARIGGAVVGTFAARVFPGNDRAWVSLTSAQTLLPRVANGSSFVTVRGSTEAAVGAAVC RSGRTTGYQCGTITAKNVTANYAEGAVRGLTQGNACMGRGDSGGSWITSAGQAQGVMSGG NVQSNGNNCGIPASQRSSLFERLQPILSQYGLSLVTG
- Number of residues
- 397
- Molecular Weight
- 41076.9
- Theoretical pI
- 9.61
- GO Classification
- Functionsserine-type endopeptidase activityComponentsextracellular region
- General Function
- Serine-type endopeptidase activity
- Specific Function
- Not Available
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0003898|1194 bp ATGTACGTATCGAACCACCGTTCGCGCCGCGTCGCGCGCGTGTCCGTTTCCTGCCTCGTC GCCGCGCTGGCGGCGATGTCCTGCGGCGCTGCGCTGGCGGCCGATCAGGTCGATCCTCAG CTGAAATTCGCCATGCAGCGCGATCTGGGCATCTTCCCGACCCAGCTGCCGCAGTACCTG CAGACCGAAAAACTCGCCCGCACCCAGGCCGCGGCGATCGAGCGCGAGTTCGGTGCCCAG TTCGCCGGCAGCTGGATCGAGCGCAACGAAGACGGCAGCTTCAAGCTCGTCGCCGCGACC TCGGGCGCGCGCAAGTCGAGCACGCTGGGCGGGGTGGAAGTGCGCAACGTGCGCTACAGC CTCAAGCAGCTGCAGTCGGCGATGGAGCAGCTCGACGCCGGCGCCAACGCGCGGGTGAAG GGCGTCAGCAAGCCGCTCGACGGCGTGCAGAGCTGGTACGTGGATCCGCGCAGCAACGCG GTGGTGGTCAAAGTCGACGACGGCGCGACGGAAGCCGGCGTCGACTTCGTCGCCCTCAGC GGCGCCGACAGCGCGCAGGTGCGGATCGAAAGCTCGCCGGGCAAGCTGCAGACCACGGCC AACATCGTCGGCGGCATCGAGTACTCGATCAACAACGCCTCGCTGTGCTCGGTCGGCTTC TCGGTCACCCGCGGCGCGACCAAGGGCTTCGTCACCGCCGGCCACTGCGGCACGGTGAAT GCGACCGCGCGCATCGGCGGCGCGGTGGTCGGCACCTTCGCCGCGCGCGTGTTCCCCGGC AACGACCGCGCCTGGGTCAGCCTGACCAGCGCGCAGACCCTGCTGCCGCGCGTGGCCAAC GGCAGCAGCTTCGTCACCGTGCGCGGCAGCACCGAGGCCGCGGTCGGCGCGGCGGTGTGC CGCTCGGGCCGCACCACCGGTTACCAGTGCGGCACCATCACCGCCAAGAACGTCACCGCC AACTACGCCGAAGGTGCGGTGCGCGGCCTGACCCAGGGCAACGCCTGTATGGGCCGCGGC GATTCGGGCGGTTCGTGGATCACCAGCGCCGGCCAGGCGCAGGGCGTGATGTCGGGCGGC AACGTGCAGTCCAACGGCAACAACTGCGGCATCCCGGCCTCGCAGCGCAGCAGCCTGTTC GAGCGTCTGCAGCCGATCCTGAGCCAGTACGGCCTGAGCCTGGTCACCGGCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P00778 UniProtKB Entry Name PRLA_LYSEN GenBank Protein ID 150130 GenBank Gene ID J04052 - General References
- Epstein DM, Wensink PC: The alpha-lytic protease gene of Lysobacter enzymogenes. The nucleotide sequence predicts a large prepro-peptide with homology to pro-peptides of other chymotrypsin-like enzymes. J Biol Chem. 1988 Nov 15;263(32):16586-90. [Article]
- Silen JL, McGrath CN, Smith KR, Agard DA: Molecular analysis of the gene encoding alpha-lytic protease: evidence for a preproenzyme. Gene. 1988 Sep 30;69(2):237-44. [Article]
- Olson MO, Nagabhushan N, Dzwiniel M, Smillie LB, Whitaker DR: Primary structure of alpha-lytic protease: a bacterial homologue of the pancreatic serine proteases. Nature. 1970 Oct 31;228(5270):438-42. [Article]
- Brayer GD, Delbaere LT, James MN: Molecular structure of the alpha-lytic protease from Myxobacter 495 at 2.8 Angstroms resolution. J Mol Biol. 1979 Jul 15;131(4):743-75. [Article]
- Fujinaga M, Delbaere LT, Brayer GD, James MN: Refined structure of alpha-lytic protease at 1.7 A resolution. Analysis of hydrogen bonding and solvent structure. J Mol Biol. 1985 Aug 5;184(3):479-502. [Article]
- Peters RJ, Shiau AK, Sohl JL, Anderson DE, Tang G, Silen JL, Agard DA: Pro region C-terminus:protease active site interactions are critical in catalyzing the folding of alpha-lytic protease. Biochemistry. 1998 Sep 1;37(35):12058-67. [Article]
- Sauter NK, Mau T, Rader SD, Agard DA: Structure of alpha-lytic protease complexed with its pro region. Nat Struct Biol. 1998 Nov;5(11):945-50. [Article]