Cholera enterotoxin subunit B
Details
- Name
- Cholera enterotoxin subunit B
- Synonyms
- Cholera enterotoxin B chain
- Cholera enterotoxin gamma chain
- Choleragenoid
- toxB
- Gene Name
- ctxB
- Organism
- Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
- Amino acid sequence
>lcl|BSEQ0016453|Cholera enterotoxin subunit B MIKLKFGVFFTVLLSSAYAHGTPQNITDLCAEYHNTQIYTLNDKIFSYTESLAGKREMAI ITFKNGAIFQVEVPGSQHIDSQKKAIERMKDTLRIAYLTEAKVEKLCVWNNKTPHAIAAI SMAN
- Number of residues
- 124
- Molecular Weight
- 13957.055
- Theoretical pI
- 9.09
- GO Classification
- Functionshost cell surface bindingProcesseskilling of cells of other organism / pathogenesis / positive regulation of tyrosine phosphorylation of Stat3 protein / protein ADP-ribosylationComponentsextracellular region / host cell plasma membrane / membrane
- General Function
- Host cell surface binding
- Specific Function
- The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
- Pfam Domain Function
- Enterotoxin_b (PF01376)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0016454|Cholera enterotoxin subunit B (ctxB) ATGATTAAATTAAAATTTGGTGTTTTTTTTACAGTTTTACTATCTTCAGCATATGCACAT GGAACACCTCAAAATATTACTGATTTGTGTGCAGAATACCACAACACACAAATATATACG CTAAATGATAAGATATTTTCGTATACAGAATCTCTAGCTGGAAAAAGAGAGATGGCTATC ATTACTTTTAAGAATGGTGCAATTTTTCAAGTAGAAGTACCAGGTAGTCAACATATAGAT TCACAAAAAAAAGCGATTGAAAGGATGAAGGATACCCTGAGGATTGCATATCTTACTGAA GCTAAAGTCGAAAAGTTATGTGTATGGAATAATAAAACGCCTCATGCGATTGCCGCAATT AGTATGGCAAATTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P01556 UniProtKB Entry Name CHTB_VIBCH GenBank Protein ID 48348 GenBank Gene ID X00171 - General References
- Lockman H, Kaper JB: Nucleotide sequence analysis of the A2 and B subunits of Vibrio cholerae enterotoxin. J Biol Chem. 1983 Nov 25;258(22):13722-6. [Article]
- Mekalanos JJ, Swartz DJ, Pearson GD, Harford N, Groyne F, de Wilde M: Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development. Nature. 1983 Dec 8-14;306(5943):551-7. [Article]
- Lebens M, Holmgren J: Structure and arrangement of the cholera toxin genes in Vibrio cholerae O139. FEMS Microbiol Lett. 1994 Apr 1;117(2):197-202. [Article]
- Heidelberg JF, Eisen JA, Nelson WC, Clayton RA, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Umayam L, Gill SR, Nelson KE, Read TD, Tettelin H, Richardson D, Ermolaeva MD, Vamathevan J, Bass S, Qin H, Dragoi I, Sellers P, McDonald L, Utterback T, Fleishmann RD, Nierman WC, White O, Salzberg SL, Smith HO, Colwell RR, Mekalanos JJ, Venter JC, Fraser CM: DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature. 2000 Aug 3;406(6795):477-83. [Article]
- Kurosky A, Markel DE, Peterson JW: Covalent structure of the beta chain of cholera enterotoxin. J Biol Chem. 1977 Oct 25;252(20):7257-64. [Article]
- Lai CY: Determination of the primary structure of cholera toxin B subunit. J Biol Chem. 1977 Oct 25;252(20):7249-56. [Article]
- Gill DM: The arrangement of subunits in cholera toxin. Biochemistry. 1976 Mar 23;15(6):1242-8. [Article]
- Fujinaga Y, Wolf AA, Rodighiero C, Wheeler H, Tsai B, Allen L, Jobling MG, Rapoport T, Holmes RK, Lencer WI: Gangliosides that associate with lipid rafts mediate transport of cholera and related toxins from the plasma membrane to endoplasmic reticulm. Mol Biol Cell. 2003 Dec;14(12):4783-93. Epub 2003 Sep 17. [Article]
- Merritt EA, Sarfaty S, van den Akker F, L'Hoir C, Martial JA, Hol WG: Crystal structure of cholera toxin B-pentamer bound to receptor GM1 pentasaccharide. Protein Sci. 1994 Feb;3(2):166-75. [Article]
- Zhang RG, Westbrook ML, Westbrook EM, Scott DL, Otwinowski Z, Maulik PR, Reed RA, Shipley GG: The 2.4 A crystal structure of cholera toxin B subunit pentamer: choleragenoid. J Mol Biol. 1995 Aug 25;251(4):550-62. [Article]
- Merritt EA, Sarfaty S, Jobling MG, Chang T, Holmes RK, Hirst TR, Hol WG: Structural studies of receptor binding by cholera toxin mutants. Protein Sci. 1997 Jul;6(7):1516-28. [Article]
- Aman AT, Fraser S, Merritt EA, Rodigherio C, Kenny M, Ahn M, Hol WG, Williams NA, Lencer WI, Hirst TR: A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8536-41. Epub 2001 Jul 10. [Article]
- Pickens JC, Merritt EA, Ahn M, Verlinde CL, Hol WG, Fan E: Anchor-based design of improved cholera toxin and E. coli heat-labile enterotoxin receptor binding antagonists that display multiple binding modes. Chem Biol. 2002 Feb;9(2):215-24. [Article]
- Zhang Z, Merritt EA, Ahn M, Roach C, Hou Z, Verlinde CL, Hol WG, Fan E: Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin. J Am Chem Soc. 2002 Nov 6;124(44):12991-8. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02213 Metanitrophenyl-Alpha-D-Galactoside experimental unknown Details DB02474 BMSC-0013 experimental unknown Details DB02572 1,3-bis-([3-[3-[3-(4-{3-[3-nitro-5-(galactopyranosyloxy)-benzoylamino]-propyl}-piperazin-1-yl)-propylamino-3,4-dioxo-cyclobutenyl]-amino-propoxy-ethoxy-ethoxy]-propyl-]amino-carbonyloxy)-2-amino-propane experimental unknown Details DB02574 BV2 experimental unknown Details DB02802 3-(alpha-D-Galactopyranosyloxy)-5-nitrobenzamide experimental unknown Details DB02903 1,3-bis-([[3-(4-{3-[3-nitro-5-(galactopyranosyloxy)-benzoylamino]-propyl}-piperazin-1-yl)-propylamino-3,4-dioxo-cyclobutenyl]-amino-ethyl]-amino-carbonyloxy)-2-amino-propane experimental unknown Details DB03077 3-Amino-4-{3-[2-(2-Propoxy-Ethoxy)-Ethoxy]-Propylamino}-Cyclobut-3-Ene-1,2-Dione experimental unknown Details DB03235 N-{3-[4-(3-aminopropyl)piperazin-1-yl]propyl}-3-(alpha-D-galactopyranosyloxy)-5-nitrobenzamide experimental unknown Details DB03524 N-[3-[4-(3-aminopropyl)piperazin-1-yl]propyl]-3-[(2-thiophen-2-ylacetyl)amino]-5-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybenzamide experimental unknown Details DB03721 N-acetyl-alpha-neuraminic acid experimental unknown Details DB04073 N-{3-[4-(3-amino-propyl)-piperazin-1-yl]-propyl}-3-nitro-5-(galactopyranosyl)-beta-benzamide experimental unknown Details DB04210 3-(alpha-D-galactopyranosyloxy)-N-(3-{4-[3-({2-[(3-{4-[3-({[3-(hexopyranosyloxy)-5-nitrophenyl]carbonyl}amino)propyl]piperazin-1-yl}propyl)amino]-3,4-dioxocyclobut-1-en-1-yl}amino)propyl]piperazin-1-yl}propyl)-5-nitrobenzamide experimental unknown Details DB02379 Beta-D-Glucose experimental unknown Details