Interferon beta
Details
- Name
- Interferon beta
- Synonyms
- Fibroblast interferon
- IFB
- IFN-beta
- IFNB
- Gene Name
- IFNB1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010650|Interferon beta MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR LTGYLRN
- Number of residues
- 187
- Molecular Weight
- 22293.68
- Theoretical pI
- 8.91
- GO Classification
- Functionschloramphenicol O-acetyltransferase activity / cytokine activity / type I interferon receptor bindingProcessesadaptive immune response / B cell activation involved in immune response / B cell differentiation / B cell proliferation / blood coagulation / cell surface receptor signaling pathway / cellular response to dexamethasone stimulus / cellular response to exogenous dsRNA / cellular response to interferon-beta / cellular response to virus / cytokine-mediated signaling pathway / defense response to bacterium / defense response to virus / humoral immune response / innate immune response / natural killer cell activation / natural killer cell activation involved in immune response / negative regulation of T cell differentiation / negative regulation of T-helper 2 cell cytokine production / negative regulation of viral genome replication / positive regulation of apoptotic signaling pathway / positive regulation of innate immune response / positive regulation of peptidyl-serine phosphorylation of STAT protein / positive regulation of transcription from RNA polymerase II promoter / regulation of MHC class I biosynthetic process / regulation of type I interferon-mediated signaling pathway / response to exogenous dsRNA / response to virus / T cell activation involved in immune response / type I interferon signaling pathwayComponentsextracellular region / extracellular space
- General Function
- Type i interferon receptor binding
- Specific Function
- Has antiviral, antibacterial and anticancer activities.
- Pfam Domain Function
- Interferon (PF00143)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0010651|Interferon beta (IFNB1) ATGACCAACAAGTGTCTCCTCCAAATTGCTCTCCTGTTGTGCTTCTCCACTACAGCTCTT TCCATGAGCTACAACTTGCTTGGATTCCTACAAAGAAGCAGCAATTTTCAGTGTCAGAAG CTCCTGTGGCAATTGAATGGGAGGCTTGAATACTGCCTCAAGGACAGGATGAACTTTGAC ATCCCTGAGGAGATTAAGCAGCTGCAGCAGTTCCAGAAGGAGGACGCCGCATTGACCATC TATGAGATGCTCCAGAACATCTTTGCTATTTTCAGACAAGATTCATCTAGCACTGGCTGG AATGAGACTATTGTTGAGAACCTCCTGGCTAATGTCTATCATCAGATAAACCATCTGAAG ACAGTCCTGGAAGAAAAACTGGAGAAAGAAGATTTCACCAGGGGAAAACTCATGAGCAGT CTGCACCTGAAAAGATATTATGGGAGGATTCTGCATTACCTGAAGGCCAAGGAGTACAGT CACTGTGCCTGGACCATAGTCAGAGTGGAAATCCTAAGGAACTTTTACTTCATTAACAGA CTTACAGGTTACCTCCGAAACTGA
- Chromosome Location
- 9
- Locus
- 9p21
- External Identifiers
Resource Link UniProtKB ID P01574 UniProtKB Entry Name IFNB_HUMAN GenBank Protein ID 32638 GenBank Gene ID V00534 GenAtlas ID IFNB1 HGNC ID HGNC:5434 - General References
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- Taniguchi T, Ohno S, Fujii-Kuriyama Y, Muramatsu M: The nucleotide sequence of human fibroblast interferon cDNA. Gene. 1980 Jun;10(1):11-5. [Article]
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