Lithostathine-1-alpha
Details
- Name
- Lithostathine-1-alpha
- Synonyms
- ICRF
- Islet cells regeneration factor
- Islet of Langerhans regenerating protein
- Pancreatic stone protein
- Pancreatic thread protein
- PSP
- PSPS
- PSPS1
- PTP
- REG
- REG-1-alpha
- Regenerating islet-derived protein 1-alpha
- Regenerating protein I alpha
- Gene Name
- REG1A
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010642|Lithostathine-1-alpha MAQTSSYFMLISCLMFLSQSQGQEAQTELPQARISCPEGTNAYRSYCYYFNEDRETWVDA DLYCQNMNSGNLVSVLTQAEGAFVASLIKESGTDDFNVWIGLHDPKKNRRWHWSSGSLVS YKSWGIGAPSSVNPGYCVSLTSSTGFQKWKDVPCEDKFSFVCKFKN
- Number of residues
- 166
- Molecular Weight
- 18730.845
- Theoretical pI
- 5.73
- GO Classification
- Functionscarbohydrate binding / growth factor activityProcessespositive regulation of cell proliferationComponentsextracellular exosome
- General Function
- Growth factor activity
- Specific Function
- Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.
- Pfam Domain Function
- Lectin_C (PF00059)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0010643|Lithostathine-1-alpha (REG1A) ATGGCTCAGACCAGCTCATACTTCATGCTGATCTCCTGCCTGATGTTTCTGTCTCAGAGC CAAGGCCAAGAGGCCCAGACAGAGTTGCCCCAGGCCCGGATCAGCTGCCCAGAAGGCACC AATGCCTATCGCTCCTACTGCTACTACTTTAATGAAGACCGTGAGACCTGGGTTGATGCA GATCTCTATTGCCAGAACATGAATTCGGGCAACCTGGTGTCTGTGCTCACCCAGGCCGAG GGTGCCTTTGTGGCCTCACTGATTAAGGAGAGTGGCACTGATGACTTCAATGTCTGGATT GGCCTCCATGACCCCAAAAAGAACCGCCGCTGGCACTGGAGCAGTGGGTCCCTGGTCTCC TACAAGTCCTGGGGCATTGGAGCCCCAAGCAGTGTTAATCCTGGCTACTGTGTGAGCCTG ACCTCAAGCACAGGATTCCAGAAATGGAAGGATGTGCCTTGTGAAGACAAGTTCTCCTTT GTCTGCAAGTTCAAAAACTAG
- Chromosome Location
- 2
- Locus
- 2p12
- External Identifiers
Resource Link UniProtKB ID P05451 UniProtKB Entry Name REG1A_HUMAN GenBank Protein ID 623413 GenBank Gene ID M27190 GenAtlas ID REG1A HGNC ID HGNC:9951 - General References
- Terazono K, Yamamoto H, Takasawa S, Shiga K, Yonemura Y, Tochino Y, Okamoto H: A novel gene activated in regenerating islets. J Biol Chem. 1988 Feb 15;263(5):2111-4. [Article]
- Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H: Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. The reg protein, pancreatic stone protein, and pancreatic thread protein are one and the same product of the gene. J Biol Chem. 1990 May 5;265(13):7432-9. [Article]
- Giorgi D, Bernard JP, Rouquier S, Iovanna J, Sarles H, Dagorn JC: Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis. J Clin Invest. 1989 Jul;84(1):100-6. [Article]
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- De Caro AM, Bonicel JJ, Rouimi P, De Caro JD, Sarles H, Rovery M: Complete amino acid sequence of an immunoreactive form of human pancreatic stone protein isolated from pancreatic juice. Eur J Biochem. 1987 Oct 1;168(1):201-7. [Article]
- Montalto G, Bonicel J, Multigner L, Rovery M, Sarles H, De Caro A: Partial amino acid sequence of human pancreatic stone protein, a novel pancreatic secretory protein. Biochem J. 1986 Aug 15;238(1):227-32. [Article]
- Gross J, Carlson RI, Brauer AW, Margolies MN, Warshaw AL, Wands JR: Isolation, characterization, and distribution of an unusual pancreatic human secretory protein. J Clin Invest. 1985 Dec;76(6):2115-26. [Article]
- De Caro AM, Adrich Z, Fournet B, Capon C, Bonicel JJ, De Caro JD, Rovery M: N-terminal sequence extension in the glycosylated forms of human pancreatic stone protein. The 5-oxoproline N-terminal chain is O-glycosylated on the 5th amino acid residue. Biochim Biophys Acta. 1989 Feb 23;994(3):281-4. [Article]
- Rouimi P, Bonicel J, Rovery M, De Caro A: Cleavage of the Arg-Ile bond in the native polypeptide chain of human pancreatic stone protein. FEBS Lett. 1987 Jun 1;216(2):195-9. [Article]
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- Itoh T, Tsuzuki H, Katoh T, Teraoka H, Matsumoto K, Yoshida N, Terazono K, Watanabe T, Yonekura H, Yamamoto H, et al.: Isolation and characterization of human reg protein produced in Saccharomyces cerevisiae. FEBS Lett. 1990 Oct 15;272(1-2):85-8. [Article]
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