Tyrosine-protein kinase Lck
Details
- Name
- Tyrosine-protein kinase Lck
- Synonyms
- 2.7.10.2
- Leukocyte C-terminal Src kinase
- LSK
- Lymphocyte cell-specific protein-tyrosine kinase
- p56-LCK
- Protein YT16
- Proto-oncogene Lck
- T cell-specific protein-tyrosine kinase
- Gene Name
- LCK
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037093|Tyrosine-protein kinase Lck MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASP LQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKAN SLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKH YKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKPWWEDEWEV PRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRL VRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNY IHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIK SDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKER PEDRPTFDYLRSVLEDFFTATEGQYQPQP
- Number of residues
- 509
- Molecular Weight
- 58000.15
- Theoretical pI
- 5.03
- GO Classification
- Functionsantigen binding / ATP binding / ATPase binding / CD4 receptor binding / CD8 receptor binding / glycoprotein binding / identical protein binding / non-membrane spanning protein tyrosine kinase activity / phosphatidylinositol 3-kinase binding / protein C-terminus binding / protein kinase binding / protein phosphatase binding / protein serine/threonine phosphatase activity / protein tyrosine kinase activity / SH2 domain bindingProcessesactivation of cysteine-type endopeptidase activity involved in apoptotic process / aging / B cell receptor signaling pathway / blood coagulation / cellular response to peptide hormone stimulus / cellular zinc ion homeostasis / epidermal growth factor receptor signaling pathway / Fc-epsilon receptor signaling pathway / fibroblast growth factor receptor signaling pathway / hemopoiesis / innate immune response / leukocyte migration / neurotrophin TRK receptor signaling pathway / peptidyl-tyrosine autophosphorylation / phosphatidylinositol-mediated signaling / platelet activation / positive regulation of gamma-delta T cell differentiation / positive regulation of gene expression / positive regulation of intrinsic apoptotic signaling pathway / positive regulation of T cell activation / positive regulation of T cell receptor signaling pathway / positive regulation of tyrosine phosphorylation of Stat5 protein / positive regulation of uterine smooth muscle contraction / protein dephosphorylation / protein phosphorylation / regulation of cell proliferation / regulation of defense response to virus by virus / regulation of lymphocyte activation / release of sequestered calcium ion into cytosol / response to drug / response to hydrogen peroxide / response to mechanical stimulus / response to zinc ion / T cell costimulation / T cell differentiation / T cell receptor signaling pathway / transmembrane receptor protein tyrosine kinase signaling pathway / viral processComponentscell-cell junction / cytosol / endocytic vesicle / extracellular exosome / extrinsic component of cytoplasmic side of plasma membrane / immunological synapse / membrane raft / pericentriolar material / plasma membrane
- General Function
- Sh2 domain binding
- Specific Function
- Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0020487|Tyrosine-protein kinase Lck (LCK) ATGGGCTGTGGCTGCAGCTCACACCCGGAAGATGACTGGATGGAAAACATCGATGTGTGT GAGAACTGCCATTATCCCATAGTCCCACTGGATGGCAAGGGCACGCTGCTCATCCGAAAT GGCTCTGAGGTGCGGGACCCACTGGTTACCTACGAAGGCTCCAATCCGCCGGCTTCCCCA CTGCAAGACAACCTGGTTATCGCTCTGCACAGCTATGAGCCCTCTCACGACGGAGATCTG GGCTTTGAGAAGGGGGAACAGCTCCGCATCCTGGAGCAGAGCGGCGAGTGGTGGAAGGCG CAGTCCCTGACCACGGGCCAGGAAGGCTTCATCCCCTTCAATTTTGTGGCCAAAGCGAAC AGCCTGGAGCCCGAACCCTGGTTCTTCAAGAACCTGAGCCGCAAGGACGCGGAGCGGCAG CTCCTGGCGCCCGGGAACACTCACGGCTCCTTCCTCATCCGGGAGAGCGAGAGCACCGCG GGATCGTTTTCACTGTCGGTCCGGGACTTCGACCAGAACCAGGGAGAGGTGGTGAAACAT TACAAGATCCGTAATCTGGACAACGGTGGCTTCTACATCTCCCCTCGAATCACTTTTCCC GGCCTGCATGAACTGGTCCGCCATTACACCAATGCTTCAGATGGGCTGTGCACACGGTTG AGCCGCCCCTGCCAGACCCAGAAGCCCCAGAAGCCGTGGTGGGAGGACGAGTGGGAGGTT CCCAGGGAGACGCTGAAGCTGGTGGAGCGGCTGGGGGCTGGACAGTTCGGGGAGGTGTGG ATGGGGTACTACAACGGGCACACGAAGGTGGCGGTGAAGAGCCTGAAGCAGGGCAGCATG TCCCCGGACGCCTTCCTGGCCGAGGCCAACCTCATGAAGCAGCTGCAACACCAGCGGCTG GTTCGGCTCTACGCTGTGGTCACCCAGGAGCCCATCTACATCATCACTGAATACATGGAG AATGGGAGTCTAGTGGATTTTCTCAAGACCCCTTCAGGCATCAAGTTGACCATCAACAAA CTCCTGGACATGGCAGCCCAAATTGCAGAAGGCATGGCATTCATTGAAGAGCGGAATTAT ATTCATCGTGACCTTCGGGCTGCCAACATTCTGGTGTCTGACACCCTGAGCTGCAAGATT GCAGACTTTGGCCTAGCACGCCTCATTGAGGACAACGAGTACACAGCCAGGGAGGGGGCC AAGTTTCCCATTAAGTGGACAGCGCCAGAAGCCATTAACTACGGGACATTCACCATCAAG TCAGATGTGTGGTCTTTTGGGATCCTGCTGACGGAAATTGTCACCCACGGCCGCATCCCT TACCCAGGGATGACCAACCCGGAGGTGATTCAGAACCTGGAGCGAGGCTACCGCATGGTG CGCCCTGACAACTGTCCAGAGGAGCTGTACCAACTCATGAGGCTGTGCTGGAAGGAGCGC CCAGAGGACCGGCCCACCTTTGACTACCTGCGCAGTGTGCTGGAGGACTTCTTCACGGCC ACAGAGGGCCAGTACCAGCCTCAGCCTTGA
- Chromosome Location
- 1
- Locus
- 1p34.3
- External Identifiers
Resource Link UniProtKB ID P06239 UniProtKB Entry Name LCK_HUMAN GenBank Protein ID 36808 GenBank Gene ID X05027 GenAtlas ID LCK HGNC ID HGNC:6524 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01254 Dasatinib approved, investigational yes inhibitormultitarget Details DB01830 AP-22408 experimental unknown Details DB02010 Staurosporine experimental unknown Details DB03023 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine experimental unknown Details DB04003 {4-[(2S)-2-Acetamido-3-({(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl}amino)-3-oxopropyl]-2-phosphonophenoxy}acetic acid experimental unknown Details DB04395 Phosphoaminophosphonic Acid-Adenylate Ester experimental unknown Details DB06925 3-(2-AMINOQUINAZOLIN-6-YL)-4-METHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE experimental unknown Details DB07146 2,3-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-B]PYRIDIN-4-AMINE experimental unknown Details DB07297 5,6-DIPHENYL-N-(2-PIPERAZIN-1-YLETHYL)FURO[2,3-D]PYRIMIDIN-4-AMINE experimental unknown Details DB08055 N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine experimental unknown Details DB08056 N-(2,6-dimethylphenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine experimental unknown Details DB08057 N-(2-chloro-6-methylphenyl)-8-[(3S)-3-methylpiperazin-1-yl]imidazo[1,5-a]quinoxalin-4-amine experimental unknown Details DB08901 Ponatinib approved, investigational unknown inhibitor Details DB09079 Nintedanib approved unknown inhibitor Details DB12010 Fostamatinib approved, investigational unknown inhibitor Details DB15035 Zanubrutinib approved, investigational unknown inhibitor Details DB16656 Zotiraciclib investigational unknown inhibitor Details