Muscarinic acetylcholine receptor M4
Details
- Name
- Muscarinic acetylcholine receptor M4
- Synonyms
- Not Available
- Gene Name
- CHRM4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010280|Muscarinic acetylcholine receptor M4 MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
- Number of residues
- 479
- Molecular Weight
- 53048.65
- Theoretical pI
- 10.34
- GO Classification
- FunctionsG-protein coupled acetylcholine receptor activity / guanyl-nucleotide exchange factor activityProcessesadenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway / cell proliferation / cell surface receptor signaling pathway / G-protein coupled acetylcholine receptor signaling pathway / phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway / regulation of locomotion / response to organic substance / sensory perception of chemical stimulus / signal transduction / synaptic transmission, cholinergicComponentsasymmetric synapse / axon terminus / cell junction / cytoplasm / integral component of plasma membrane / neuronal cell body / plasma membrane / postsynaptic density / postsynaptic membrane / sarcolemma / synapse
- General Function
- Guanyl-nucleotide exchange factor activity
- Specific Function
- The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 32-54 69-89 107-128 149-171 194-216 402-422 437-456
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010281|Muscarinic acetylcholine receptor M4 (CHRM4) ATGGCCAACTTCACACCTGTCAATGGCAGCTCGGGCAATCAGTCCGTGCGCCTGGTCACG TCATCATCCCACAATCGCTATGAGACGGTGGAAATGGTCTTCATTGCCACAGTGACAGGC TCCCTGAGCCTGGTGACTGTCGTGGGCAACATCCTGGTGATGCTGTCCATCAAGGTCAAC AGGCAGCTGCAGACAGTCAACAACTACTTCCTCTTCAGCCTGGCGTGTGCTGATCTCATC ATAGGCGCCTTCTCCATGAACCTCTACACCGTGTACATCATCAAGGGCTACTGGCCCCTG GGCGCCGTGGTCTGCGACCTGTGGCTGGCCCTGGACTACGTGGTGAGCAACGCCTCCGTC ATGAACCTTCTCATCATCAGCTTTGACCGCTACTTCTGCGTCACCAAGCCTCTCACCTAC CCTGCCCGGCGCACCACCAAGATGGCAGGCCTCATGATTGCTGCTGCCTGGGTACTGTCC TTCGTGCTCTGGGCGCCTGCCATCTTGTTCTGGCAGTTTGTGGTGGGTAAGCGGACGGTG CCCGACAACCAGTGCTTCATCCAGTTCCTGTCCAACCCAGCAGTGACCTTTGGCACAGCC ATTGCTGCCTTCTACCTGCCTGTGGTCATCATGACGGTGCTGTACATCCACATCTCCCTG GCCAGTCGCAGCCGAGTCCACAAGCACCGGCCCGAGGGCCCGAAGGAGAAGAAAGCCAAG ACGCTGGCCTTCCTCAAGAGCCCACTAATGAAGCAGAGCGTCAAGAAGCCCCCGCCCGGG GAGGCCGCCCGGGAGGAGCTGCGCAATGGCAAGCTGGAGGAGGCCCCCCCGCCAGCGCTG CCACCGCCACCGCGCCCCGTGGCTGATAAGGACACTTCCAATGAGTCCAGCTCAGGCAGT GCCACCCAGAACACCAAGGAACGCCCAGCCACAGAGCTGTCCACCACAGAGGCCACCACG CCCGCCATGCCCGCCCCTCCCCTGCAGCCGCGGGCCCTCAACCCAGCCTCCAGATGGTCC AAGATCCAGATTGTGACGAAGCAGACAGGCAATGAGTGTGTGACAGCCATTGAGATTGTG CCTGCCACGCCGGCTGGCATGCGCCCTGCGGCCAACGTGGCCCGCAAGTTCGCCAGCATC GCTCGCAACCAGGTGCGCAAGAAGCGGCAGATGGCGGCCCGGGAGCGCAAAGTGACACGA ACGATCTTTGCCATTCTGCTAGCCTTCATCCTCACCTGGACGCCCTACAACGTCATGGTC CTGGTGAACACCTTCTGCCAGAGCTGCATCCCTGACACGGTGTGGTCCATTGGCTACTGG CTCTGCTACGTCAACAGCACCATCAACCCTGCCTGCTATGCTCTGTGCAACGCCACCTTT AAAAAGACCTTCCGGCACCTGCTGCTGTGCCAGTATCGGAACATCGGCACTGCCAGGTAG
- Chromosome Location
- 11
- Locus
- 11p12-p11.2
- External Identifiers
Resource Link UniProtKB ID P08173 UniProtKB Entry Name ACM4_HUMAN GenBank Protein ID 61970253 GenBank Gene ID M16405 GenAtlas ID CHRM4 HGNC ID HGNC:1953 - General References
- Bonner TI, Buckley NJ, Young AC, Brann MR: Identification of a family of muscarinic acetylcholine receptor genes. Science. 1987 Jul 31;237(4814):527-32. [Article]
- Bonner TI, Young AC, Brann MR, Buckley NJ: Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes. Neuron. 1988 Jul;1(5):403-10. [Article]
- Peralta EG, Ashkenazi A, Winslow JW, Smith DH, Ramachandran J, Capon DJ: Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors. EMBO J. 1987 Dec 20;6(13):3923-9. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00767 Benzquinamide withdrawn yes antagonist Details DB00809 Tropicamide approved, investigational yes antagonist Details DB00334 Olanzapine approved, investigational unknown antagonist Details DB00387 Procyclidine approved yes antagonist Details DB00572 Atropine approved, vet_approved yes antagonist Details DB00725 Homatropine methylbromide approved yes antagonist Details DB01069 Promethazine approved, investigational unknown antagonist Details DB01403 Methotrimeprazine approved, investigational unknown antagonist Details DB05752 ALKS 27 investigational unknown Details DB00622 Nicardipine approved, investigational unknown antagonist Details DB01224 Quetiapine approved unknown ligand Details DB00246 Ziprasidone approved unknown antagonist Details DB00363 Clozapine approved unknown partial agonist Details DB00496 Darifenacin approved, investigational unknown antagonist Details DB00424 Hyoscyamine approved unknown antagonist Details DB01239 Chlorprothixene approved, experimental, investigational, withdrawn no antagonist Details DB01142 Doxepin approved, investigational unknown antagonist Details DB01151 Desipramine approved, investigational no antagonist Details DB00458 Imipramine approved no antagonist Details DB00835 Brompheniramine approved unknown antagonist Details DB00747 Scopolamine approved, investigational yes antagonist Details DB00376 Trihexyphenidyl approved unknown antagonist Details DB01591 Solifenacin approved unknown antagonist Details DB00934 Maprotiline approved, investigational no antagonist Details DB01036 Tolterodine approved, investigational yes antagonist Details DB06702 Fesoterodine approved unknown antagonist Details DB01625 Isopropamide approved, vet_approved unknown antagonist Details DB08897 Aclidinium approved yes antagonist Details DB00408 Loxapine approved unknown binder Details DB00342 Terfenadine approved, withdrawn unknown binder Details DB09076 Umeclidinium approved unknown antagonist Details DB06787 Hexocyclium approved unknown antagonist Details DB09167 Dosulepin approved yes antagonist Details DB03128 Acetylcholine approved, investigational unknown Details DB01409 Tiotropium approved unknown Details DB01019 Bethanechol approved unknown agonist Details DB00411 Carbamoylcholine approved unknown agonist Details DB01085 Pilocarpine approved, investigational unknown partial agonist Details DB11181 Homatropine approved yes antagonist Details DB12278 Propiverine approved, investigational unknown antagonist Details DB11235 Thonzylamine approved unknown antagonist Details DB13581 Rociverine experimental yes antagonist Details DB09089 Trimebutine approved yes antagonist Details DB14185 Aripiprazole lauroxil approved, investigational no Details DB01238 Aripiprazole approved, investigational unknown ligand Details DB00940 Methantheline approved, investigational unknown Details DB06709 Methacholine approved, investigational unknown agonist Details DB00986 Glycopyrronium approved, investigational, vet_approved yes antagonist Details DB09185 Viloxazine approved, investigational, withdrawn unknown antagonist Details DB00340 Metixene approved yes antagonist Details DB00366 Doxylamine approved, vet_approved unknown antagonist Details DB00777 Propiomazine approved unknown antagonist Details DB00543 Amoxapine approved unknown antagonist Details DB00726 Trimipramine approved unknown binder Details DB00454 Meperidine approved unknown binder Details DB00568 Cinnarizine approved, investigational unknown binder Details DB01221 Ketamine approved, vet_approved unknown binder Details DB09194 Etoperidone withdrawn unknown antagonist Details DB11855 Revefenacin approved, investigational yes antagonist Details DB00321 Amitriptyline approved unknown ligand Details DB00715 Paroxetine approved, investigational unknown inhibitor Details DB00540 Nortriptyline approved unknown antagonist Details