Asparagine synthetase [glutamine-hydrolyzing]
Details
- Name
- Asparagine synthetase [glutamine-hydrolyzing]
- Synonyms
- 6.3.5.4
- Cell cycle control protein TS11
- Glutamine-dependent asparagine synthetase
- TS11
- Gene Name
- ASNS
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0036974|Asparagine synthetase [glutamine-hydrolyzing] MCGIWALFGSDDCLSVQCLSAMKIAHRGPDAFRFENVNGYTNCCFGFHRLAVVDPLFGMQ PIRVKKYPYLWLCYNGEIYNHKKMQQHFEFEYQTKVDGEIILHLYDKGGIEQTICMLDGV FAFVLLDTANKKVFLGRDTYGVRPLFKAMTEDGFLAVCSEAKGLVTLKHSATPFLKVEPF LPGHYEVLDLKPNGKVASVEMVKYHHCRDVPLHALYDNVEKLFPGFEIETVKNNLRILFN NAVKKRLMTDRRIGCLLSGGLDSSLVAATLLKQLKEAQVQYPLQTFAIGMEDSPDLLAAR KVADHIGSEHYEVLFNSEEGIQALDEVIFSLETYDITTVRASVGMYLISKYIRKNTDSVV IFSGEGSDELTQGYIYFHKAPSPEKAEEESERLLRELYLFDVLRADRTTAAHGLELRVPF LDHRFSSYYLSLPPEMRIPKNGIEKHLLRETFEDSNLIPKEILWRPKEAFSDGITSVKNS WFKILQEYVEHQVDDAMMANAAQKFPFNTPKTKEGYYYRQVFERHYPGRADWLSHYWMPK WINATDPSARTLTHYKSAVKA
- Number of residues
- 561
- Molecular Weight
- 64369.39
- Theoretical pI
- 6.85
- GO Classification
- Functionsasparagine synthase (glutamine-hydrolyzing) activity / ATP binding / cofactor binding / protein homodimerization activityProcessesasparagine biosynthetic process / cellular amino acid biosynthetic process / cellular nitrogen compound metabolic process / cellular protein metabolic process / cellular response to glucose starvation / cellular response to hormone stimulus / endoplasmic reticulum unfolded protein response / glutamine metabolic process / L-asparagine biosynthetic process / liver development / negative regulation of apoptotic process / PERK-mediated unfolded protein response / positive regulation of mitotic cell cycle / response to amino acid / response to follicle-stimulating hormone / response to light stimulus / response to mechanical stimulus / response to methotrexate / response to toxic substance / small molecule metabolic processComponentscytosol
- General Function
- Protein homodimerization activity
- Specific Function
- Not Available
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0010013|Asparagine synthetase [glutamine-hydrolyzing] (ASNS) ATGAAGATTGCACACAGAGGTCCAGATGCATTCCGTTTTGAGAATGTCAATGGATACACC AACTGCTGCTTTGGATTTCACCGGTTGGCGGTAGTTGACCCGCTGTTTGGAATGCAGCCA ATTCGAGTGAAGAAATATCCGTATTTGTGGCTCTGTTACAATGGTGAAATCTACAACCAT AAGAAGATGCAACAGCATTTTGAATTTGAATACCAGACCAAAGTGGATGGTGAGATAATC CTTCATCTTTATGACAAAGGAGGAATTGAGCAAACAATTTGTATGTTGGATGGTGTGTTT GCATTTGTTTTACTGGATACTGCCAATAAGAAAGTGTTCCTGGGTAGAGATACATATGGA GTCAGACCTTTGTTTAAAGCAATGACAGAAGATGGATTTTTGGCTGTATGTTCAGAAGCT AAAGGTCTTGTTACATTGAAGCACTCCGCGACTCCCTTTTTAAAAGTGGAGCCTTTTCTT CCTGGACACTATGAAGTTTTGGATTTAAAGCCAAATGGCAAAGTTGCATCCGTGGAAATG GTTAAATATCATCACTGTCGGGATGTACCCCTGCACGCCCTCTATGACAATGTGGAGAAA CTCTTTCCAGGTTTTGAGATAGAAACTGTGAAGAACAACCTCAGGATCCTTTTTAATAAT GCTGTAAAGAAACGTTTGATGACAGACAGAAGGATTGGCTGCCTTTTATCAGGGGGCTTG GACTCCAGCTTGGTTGCTGCCACTCTGTTGAAGCAGCTGAAAGAAGCCCAAGTACAGTAT CCTCTCCAGACATTTGCAATTGGCATGGAAGACAGCCCCGATTTACTGGCTGCTAGAAAG GTGGCAGATCATATTGGAAGTGAACATTATGAAGTCCTTTTTAACTCTGAGGAAGGCATT CAGGCTCTGGATGAAGTCATATTTTCCTTGGAAACTTATGACATTACAACAGTTCGTGCT TCAGTAGGTATGTATTTAATTTCCAAGTATATTCGGAAGAACACAGATAGCGTGGTGATC TTCTCTGGAGAAGGATCAGATGAACTTACGCAGGGTTACATATATTTTCACAAGGCTCCT TCTCCTGAAAAAGCCGAGGAGGAGAGTGAGAGGCTTCTGAGGGAACTCTATTTGTTTGAT GTTCTCCGCGCAGATCGAACTACTGCTGCCCATGGTCTTGAACTGAGAGTCCCATTTCTA GATCATCGATTTTCTTCCTATTACTTGTCTCTGCCACCAGAAATGAGAATTCCAAAGAAT GGGATAGAAAAACATCTCCTGAGAGAGACGTTTGAGGATTCCAATCTGATACCCAAAGAG ATTCTCTGGCGACCAAAAGAAGCCTTCAGTGATGGAATAACTTCAGTTAAGAATTCCTGG TTTAAGATTTTACAGGAATACGTTGAACATCAGGTTGATGATGCAATGATGGCAAATGCA GCCCAGAAATTTCCCTTCAATACTCCTAAAACCAAAGAAGGATATTACTACCGTCAAGTC TTTGAACGCCATTACCCAGGCCGGGCTGACTGGCTGAGCCATTACTGGATGCCCAAGTGG ATCAATGCCACTGACCCTTCTGCCCGCACGCTGACCCACTACAAGTCAGCTGTCAAAGCT TAG
- Chromosome Location
- 7
- Locus
- 7q21.3
- External Identifiers
Resource Link UniProtKB ID P08243 UniProtKB Entry Name ASNS_HUMAN GenBank Protein ID 179100 GenBank Gene ID M27396 GenAtlas ID ASNS HGNC ID HGNC:753 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00128 Aspartic acid approved, nutraceutical unknown substrate Details DB00171 ATP investigational, nutraceutical unknown Details DB00174 Asparagine approved, investigational, nutraceutical unknown Details DB00142 Glutamic acid approved, nutraceutical unknown Details DB00130 L-Glutamine approved, investigational, nutraceutical unknown substrate Details