Orotidine 5'-phosphate decarboxylase
Details
- Name
- Orotidine 5'-phosphate decarboxylase
- Synonyms
- 4.1.1.23
- OMP decarboxylase
- OMPDCase
- OMPdecase
- Gene Name
- pyrF
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0011195|Orotidine 5'-phosphate decarboxylase MTLTASSSSRAVTNSPVVVALDYHNRDDALAFVDKIDPRDCRLKVGKEMFTLFGPQFVRE LQQRGFDIFLDLKFHDIPNTAAHAVAAAADLGVWMVNVHASGGARMMTAAREALVPFGKD APLLIAVTVLTSMEASDLVDLGMTLSPADYAERLAALTQKCGLDGVVCSAQEAVRFKQVF GQEFKLVTPGIRPQGSEAGDQRRIMTPEQALSAGVDYMVIGRPVTQSVDPAQTLKAINAS LQRSA
- Number of residues
- 245
- Molecular Weight
- 26349.99
- Theoretical pI
- 6.12
- GO Classification
- Functionscarboxy-lyase activity / orotidine-5'-phosphate decarboxylase activityProcesses'de novo' pyrimidine nucleobase biosynthetic process / 'de novo' UMP biosynthetic process / nucleobase-containing small molecule interconversion / UMP biosynthetic processComponentscytoplasm / cytosol
- General Function
- Orotidine-5'-phosphate decarboxylase activity
- Specific Function
- Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
- Pfam Domain Function
- OMPdecase (PF00215)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011196|Orotidine 5'-phosphate decarboxylase (pyrF) ATGACGTTAACTGCTTCATCTTCTTCCCGCGCTGTTACGAATTCTCCTGTGGTTGTTGCC CTTGATTATCATAATCGTGATGACGCGCTGGCCTTTGTCGACAAGATCGACCCACGCGAT TGTCGTCTGAAGGTCGGCAAAGAGATGTTTACATTGTTTGGGCCACAGTTTGTGCGCGAA CTTCAACAGCGTGGTTTTGATATCTTTCTTGACCTGAAATTCCACGATATCCCCAACACT GCAGCGCACGCTGTCGCTGCTGCAGCTGACTTAGGCGTGTGGATGGTGAATGTTCATGCC TCTGGTGGGGCGCGTATGATGACCGCAGCGCGTGAGGCACTGGTTCCGTTTGGCAAAGAT GCACCGCTTTTGATTGCTGTGACAGTGTTGACCAGCATGGAAGCCAGCGACCTGGTCGAT CTTGGCATGACACTGTCACCTGCAGATTATGCAGAACGTCTGGCGGCACTGACGCAAAAA TGTGGCCTTGATGGTGTGGTGTGTTCTGCTCAGGAAGCTGTGCGCTTTAAACAGGTATTC GGTCAGGAGTTCAAACTGGTTACGCCGGGCATTCGTCCGCAGGGGAGTGAAGCTGGTGAC CAGCGCCGCATTATGACGCCAGAACAGGCGTTGTCGGCTGGTGTTGATTATATGGTGATT GGTCGCCCGGTAACGCAATCGGTAGATCCAGCGCAGACGCTGAAAGCGATCAACGCCTCT TTACAGCGGAGTGCATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P08244 UniProtKB Entry Name PYRF_ECOLI GenBank Protein ID 147475 GenBank Gene ID J02768 - General References
- Turnbough CL Jr, Kerr KH, Funderburg WR, Donahue JP, Powell FE: Nucleotide sequence and characterization of the pyrF operon of Escherichia coli K12. J Biol Chem. 1987 Jul 25;262(21):10239-45. [Article]
- Aiba H, Baba T, Hayashi K, Inada T, Isono K, Itoh T, Kasai H, Kashimoto K, Kimura S, Kitakawa M, Kitagawa M, Makino K, Miki T, Mizobuchi K, Mori H, Mori T, Motomura K, Nakade S, Nakamura Y, Nashimoto H, Nishio Y, Oshima T, Saito N, Sampei G, Horiuchi T, et al.: A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map. DNA Res. 1996 Dec 31;3(6):363-77. [Article]
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Hidaka M, Akiyama M, Horiuchi T: A consensus sequence of three DNA replication terminus sites on the E. coli chromosome is highly homologous to the terR sites of the R6K plasmid. Cell. 1988 Nov 4;55(3):467-75. [Article]
- Harris P, Navarro Poulsen JC, Jensen KF, Larsen S: Structural basis for the catalytic mechanism of a proficient enzyme: orotidine 5'-monophosphate decarboxylase. Biochemistry. 2000 Apr 18;39(15):4217-24. [Article]
- Poulsen JC, Harris P, Jensen KF, Larsen S: Selenomethionine substitution of orotidine-5'-monophosphate decarboxylase causes a change in crystal contacts and space group. Acta Crystallogr D Biol Crystallogr. 2001 Sep;57(Pt 9):1251-9. Epub 2001 Aug 23. [Article]
- Harris P, Poulsen JC, Jensen KF, Larsen S: Substrate binding induces domain movements in orotidine 5'-monophosphate decarboxylase. J Mol Biol. 2002 May 10;318(4):1019-29. [Article]