Arsenate reductase
Details
- Name
- Arsenate reductase
- Synonyms
- 1.20.4.1
- Arsenical pump modifier
- Gene Name
- arsC
- Organism
- Escherichia coli
- Amino acid sequence
>lcl|BSEQ0010920|Arsenate reductase MSNITIYHNPACGTSRNTLEMIRNSGTEPTIILYLENPPSRDELVKLIADMGISVRALLR KNVEPYEQLGLAEDKFTDDQLIDFMLQHPILINRPIVVTPLGTRLCRPSEVVLDILQDAQ KGAFTKEDGEKVVDEAGKRLK
- Number of residues
- 141
- Molecular Weight
- 15830.1
- Theoretical pI
- 4.99
- GO Classification
- Functionsarsenate reductase (glutaredoxin) activityProcessesresponse to arsenic-containing substance
- General Function
- Arsenate reductase (glutaredoxin) activity
- Specific Function
- Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance.
- Pfam Domain Function
- ArsC (PF03960)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0002623|426 bp ATGAGCAACATCACTATTTATCATAACCCAGCCTGCGGCACCTCGCGTAATACGCTGGAG ATGATCCGCAACAGCGGTACCGAGCCGACCATTATTCTTTACCTTGAAAACCCGCCTTCG AGGGATGAGCTGGTTAAACTTATTGCCGATATGGGTATTTCAGTACGAGCGCTGCTGCGT AAAAACGTTGAACCTTACGAGCAACTGGGTCTTGCAGAAGATAAATTTACTGACGATCAG CTCATCGACTTTATGTTGCAACACCCAATTCTGATTAACCGTCCGATCGTGGTTACGCCG CTGGGAACCAGACTGTGCCGTCCTTCTGAAGTGGTTCTGGATATCCTACAGGATGCGCAG AAAGGGGCTTTCACTAAGGAAGACGGTGAAAAAGTCGTTGATGAAGCAGGAAAACGGCTG AAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P08692 UniProtKB Entry Name ARSC1_ECOLX GenBank Protein ID 151859 GenBank Gene ID J02591 - General References
- Chen CM, Misra TK, Silver S, Rosen BP: Nucleotide sequence of the structural genes for an anion pump. The plasmid-encoded arsenical resistance operon. J Biol Chem. 1986 Nov 15;261(32):15030-8. [Article]
- Rosen BP, Weigel U, Monticello RA, Edwards BP: Molecular analysis of an anion pump: purification of the ArsC protein. Arch Biochem Biophys. 1991 Feb 1;284(2):381-5. [Article]
- Rosen BP: The plasmid-encoded arsenical resistance pump: an anion-translocating ATPase. Res Microbiol. 1990 Mar-Apr;141(3):336-41. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01808 Thiarsahydroxy-Cysteine experimental unknown Details DB03289 Thiarsa Dihydroxy Cysteine experimental unknown Details DB03352 S-Arsonocysteine experimental unknown Details DB04456 Arsenous acid experimental, investigational unknown Details