Dihydropteridine reductase
Details
- Name
- Dihydropteridine reductase
- Synonyms
- 1.5.1.34
- DHPR
- HDHPR
- Quinoid dihydropteridine reductase
- SDR33C1
- Short chain dehydrogenase/reductase family 33C member 1
- Gene Name
- QDPR
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037041|Dihydropteridine reductase MAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSF TEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSH LATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAV LPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELT PAYF
- Number of residues
- 244
- Molecular Weight
- 25789.295
- Theoretical pI
- 7.45
- GO Classification
- Functions6,7-dihydropteridine reductase activity / electron carrier activity / NADH binding / NADPH bindingProcessescellular amino acid metabolic process / cellular nitrogen compound metabolic process / cellular response to drug / dihydrobiopterin metabolic process / L-phenylalanine catabolic process / liver development / response to aluminum ion / response to glucagon / response to lead ion / small molecule metabolic process / tetrahydrobiopterin biosynthetic processComponentscytoplasm / cytosol / extracellular exosome / mitochondrion / neuron projection
- General Function
- Nadph binding
- Specific Function
- The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases.
- Pfam Domain Function
- adh_short (PF00106)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0010377|Dihydropteridine reductase (QDPR) ATGGCGGCGGCGGCGGCTGCAGGCGAGGCGCGCCGGGTGCTGGTGTACGGCGGCAGGGGC GCTCTGGGTTCTCGATGCGTGCAGGCTTTTCGGGCCCGCAACTGGTGGGTTGCCAGCGTT GATGTGGTGGAGAATGAAGAGGCCAGCGCTAGCATCATTGTTAAAATGACAGACTCGTTC ACTGAGCAGGCTGACCAGGTGACTGCTGAGGTTGGAAAGCTCTTGGGTGAAGAGAAGGTG GATGCAATTCTTTGCGTTGCTGGAGGATGGGCCGGGGGCAATGCCAAATCCAAGTCTCTC TTTAAGAACTGTGACCTGATGTGGAAGCAGAGCATATGGACATCGACCATCTCCAGCCAT CTGGCTACCAAGCATCTCAAGGAAGGAGGCCTCCTGACCTTGGCTGGCGCAAAGGCTGCC CTGGATGGGACTCCTGGTATGATCGGGTACGGCATGGCCAAGGGTGCTGTTCACCAGCTC TGCCAGAGCCTGGCTGGGAAGAACAGCGGCATGCCGCCCGGGGCAGCCGCCATCGCTGTG CTCCCGGTTACCCTGGATACCCCGATGAACAGGAAATCAATGCCTGAGGCTGACTTCAGC TCCTGGACACCCTTAGAATTCCTAGTTGAAACTTTCCATGACTGGATCACAGGGAAAAAC CGACCGAGCTCAGGAAGCCTAATCCAGGTGGTAACCACAGAAGGAAGGACGGAACTCACC CCAGCATATTTTTAG
- Chromosome Location
- 4
- Locus
- 4p15.31
- External Identifiers
Resource Link UniProtKB ID P09417 UniProtKB Entry Name DHPR_HUMAN GenBank Protein ID 30819 GenBank Gene ID X04882 GenAtlas ID QDPR HGNC ID HGNC:9752 - General References
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