Leukotriene A-4 hydrolase
Details
- Name
- Leukotriene A-4 hydrolase
- Synonyms
- 3.3.2.6
- Leukotriene A(4) hydrolase
- LTA-4 hydrolase
- LTA4
- Gene Name
- LTA4H
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0003332|Leukotriene A-4 hydrolase MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT AMLVGKDLKVD
- Number of residues
- 611
- Molecular Weight
- 69284.64
- Theoretical pI
- 6.1
- GO Classification
- Functionsaminopeptidase activity / epoxide hydrolase activity / leukotriene-A4 hydrolase activity / metalloaminopeptidase activity / peptidase activity / peptide binding / poly(A) RNA binding / zinc ion bindingProcessesarachidonic acid metabolic process / inflammatory response / leukotriene biosynthetic process / leukotriene metabolic process / peptide catabolic process / proteolysis / response to peptide hormone / response to zinc ion / small molecule metabolic process / Type I pneumocyte differentiationComponentscytoplasm / cytosol / extracellular exosome / nucleoplasm
- General Function
- Zinc ion binding
- Specific Function
- Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0020556|Leukotriene A-4 hydrolase (LTA4H) ATGCCCGAGATAGTGGATACCTGTTCGTTGGCCTCTCCGGCTTCCGTCTGCCGGACCAAG CACCTGCACCTGCGCTGCAGCGTCGACTTTACTCGCCGGACGCTGACCGGGACTGCTGCT CTCACGGTCCAGTCTCAGGAGGACAATCTGCGCAGCCTGGTTTTGGATACAAAGGACCTT ACAATAGAAAAAGTAGTGATCAATGGACAAGAAGTCAAATATGCTCTTGGAGAAAGACAA AGTTACAAGGGATCGCCAATGGAAATCTCTCTTCCTATCGCTTTGAGCAAAAATCAAGAA ATTGTTATAGAAATTTCTTTTGAGACCTCTCCAAAATCTTCTGCTCTCCAGTGGCTCACT CCTGAACAGACTTCTGGGAAGGAACACCCATATCTCTTTAGTCAGTGCCAGGCCATCCAC TGCAGAGCAATCCTTCCTTGTCAGGACACTCCTTCTGTGAAATTAACCTATACTGCAGAG GTGTCTGTCCCTAAAGAACTGGTGGCACTTATGAGTGCTATTCGTGATGGAGAAACACCT GACCCAGAAGACCCAAGCAGGAAAATATACAAATTCATCCAAAAAGTTCCAATACCCTGC TACCTGATTGCTTTAGTTGTTGGAGCTTTAGAAAGCAGGCAAATTGGCCCAAGAACTTTG GTGTGGTCTGAGAAAGAGCAGGTGGAAAAGTCTGCTTATGAGTTTTCTGAGACTGAATCT ATGCTTAAAATAGCAGAAGATCTGGGAGGACCGTATGTATGGGGACAGTATGACCTATTG GTCCTGCCACCATCCTTCCCTTATGGTGGCATGGAGAATCCTTGCCTTACTTTTGTAACT CCTACTCTACTGGCAGGCGACAAGTCACTCTCCAATGTCATTGCACATGAAATATCTCAT AGCTGGACAGGGAATCTAGTGACCAACAAAACTTGGGATCACTTTTGGTTAAATGAGGGA CATACTGTGTACTTGGAACGCCACATTTGCGGACGATTGTTTGGTGAAAAGTTCAGACAT TTTAATGCTCTGGGAGGATGGGGAGAACTACAGAATTCGGTAAAGACATTTGGGGAGACA CATCCTTTCACCAAACTTGTGGTTGATCTGACAGATATAGACCCTGATGTAGCTTATTCT TCAGTTCCCTATGAGAAGGGCTTTGCTTTACTTTTTTACCTTGAACAACTGCTTGGAGGA CCAGAGATTTTCCTAGGATTCTTAAAAGCTTATGTTGAGAAGTTTTCCTATAAGAGCATA ACTACTGATGACTGGAAGGATTTCCTGTATTCCTATTTTAAAGATAAGGTTGATGTTCTC AATCAAGTTGATTGGAATGCCTGGCTCTACTCTCCTGGACTGCCTCCCATAAAGCCCAAT TATGATATGACTCTGACAAATGCTTGTATTGCCTTAAGTCAAAGATGGATTACTGCCAAA GAAGATGATTTAAATTCATTCAATGCCACAGACCTGAAGGATCTCTCTTCTCATCAATTG AATGAGTTTTTAGCACAGACGCTCCAGAGGGCACCTCTTCCATTGGGGCACATAAAGCGA ATGCAAGAGGTGTACAACTTCAATGCCATTAACAATTCTGAAATACGATTCAGATGGCTG CGGCTCTGCATTCAATCCAAGTGGGAGGACGCAATTCCTTTGGCGCTAAAGATGGCAACT GAACAAGGAAGAATGAAGTTTACCCGGCCCTTATTCAAGGATCTTGCTGCCTTTGACAAA TCCCATGATCAAGCTGTCCGAACCTACCAAGAGCACAAAGCAAGCATGCATCCCGTGACT GCAATGCTGGTGGGGAAAGACTTAAAAGTGGATTAA
- Chromosome Location
- 12
- Locus
- 12q22
- External Identifiers
Resource Link UniProtKB ID P09960 UniProtKB Entry Name LKHA4_HUMAN GenBank Protein ID 976396 GenBank Gene ID U27293 GenAtlas ID LTA4H HGNC ID HGNC:6710 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB03366 Imidazole experimental, investigational unknown Details DB03424 Ubenimex investigational unknown Details DB05177 DG051 investigational unknown Details DB11781 Tosedostat investigational unknown Details DB06828 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole experimental unknown Details DB06851 N-(pyridin-3-ylmethyl)aniline experimental unknown Details DB06917 (4-fluorophenyl)(pyridin-4-yl)methanone experimental unknown Details DB02352 3-(Benzyloxy)Pyridin-2-Amine experimental unknown Details DB07094 1-(2,2'-bithiophen-5-yl)methanamine experimental unknown Details DB07099 N-[4-(benzyloxy)phenyl]glycinamide experimental unknown Details DB07102 (2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acid experimental unknown Details DB07104 4-amino-N-[4-(benzyloxy)phenyl]butanamide experimental unknown Details DB07196 N-methyl-1-(2-thiophen-2-ylphenyl)methanamine experimental unknown Details DB07237 {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanone experimental unknown Details DB07258 (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol experimental unknown Details DB07259 1-(4-thiophen-2-ylphenyl)methanamine experimental unknown Details DB07260 N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline experimental unknown Details DB07292 4-(2-amino-1,3-thiazol-4-yl)phenol experimental unknown Details DB02062 N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine experimental unknown Details DB08040 Kelatorphan experimental unknown Details DB08466 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol experimental unknown Details DB01197 Captopril approved unknown inhibitor Details