Cytidylate kinase
Details
- Name
- Cytidylate kinase
- Synonyms
- 2.7.4.25
- CK
- CMP kinase
- Cytidine monophosphate kinase
- mssA
- p25
- Protein MssA
- ycaF
- ycaG
- Gene Name
- cmk
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0016490|Cytidylate kinase MTAIAPVITIDGPSGAGKGTLCKAMAEALQWHLLDSGAIYRVLALAALHHHVDVASEDAL VPLASHLDVRFVSTNGNLEVILEGEDVSGEIRTQEVANAASQVAAFPRVREALLRRQRAF RELPGLIADGRDMGTVVFPDAPVKIFLDASSEERAHRRMLQLQEKGFSVNFERLLAEIKE RDDRDRNRAVAPLVPAADALVLDSTTLSIEQVIEKALQYARQKLALA
- Number of residues
- 227
- Molecular Weight
- 24746.03
- Theoretical pI
- 5.65
- GO Classification
- FunctionsATP binding / cytidylate kinase activityProcessesnucleobase-containing small molecule interconversion / nucleotide phosphorylation / pyrimidine nucleotide metabolic processComponentscytosol
- General Function
- Cytidylate kinase activity
- Specific Function
- ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors.
- Pfam Domain Function
- Cytidylate_kin (PF02224)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0016491|Cytidylate kinase (cmk) ATGACGGCAATTGCCCCGGTTATTACCATTGATGGCCCAAGCGGTGCAGGGAAAGGCACC TTGTGTAAGGCTATGGCGGAAGCGTTGCAATGGCATCTGCTGGACTCGGGTGCAATTTAT CGCGTACTGGCATTGGCGGCATTACATCACCATGTTGATGTTGCGTCGGAAGATGCGCTG GTACCGCTGGCATCCCATCTGGATGTACGTTTTGTGTCGACCAATGGCAATCTGGAAGTG ATCCTCGAAGGGGAAGATGTCAGCGGCGAAATTCGTACTCAGGAAGTGGCGAATGCAGCT TCACAAGTCGCGGCATTCCCACGCGTTCGTGAAGCATTATTGCGTCGCCAACGCGCGTTT CGCGAATTACCAGGTCTGATTGCCGATGGCCGCGACATGGGAACGGTGGTATTCCCTGAT GCACCAGTGAAAATTTTCCTTGACGCCTCCTCGGAAGAACGTGCGCATCGCCGCATGCTA CAGTTGCAGGAGAAGGGCTTTAGTGTTAACTTTGAGCGCCTTTTGGCCGAGATCAAAGAA CGCGACGACCGCGATCGTAACCGAGCGGTAGCGCCACTGGTTCCGGCAGCCGATGCTTTA GTGTTGGATTCCACCACCTTAAGCATTGAGCAAGTGATTGAAAAAGCGCTACAATACGCG CGCCAGAAATTGGCTCTCGCATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0A6I0 UniProtKB Entry Name KCY_ECOLI GenBank Protein ID 42839 GenBank Gene ID X00785 - General References
- Pedersen S, Skouv J, Kajitani M, Ishihama A: Transcriptional organization of the rpsA operon of Escherichia coli. Mol Gen Genet. 1984;196(1):135-40. [Article]
- Oshima T, Aiba H, Baba T, Fujita K, Hayashi K, Honjo A, Ikemoto K, Inada T, Itoh T, Kajihara M, Kanai K, Kashimoto K, Kimura S, Kitagawa M, Makino K, Masuda S, Miki T, Mizobuchi K, Mori H, Motomura K, Nakamura Y, Nashimoto H, Nishio Y, Saito N, Horiuchi T, et al.: A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map. DNA Res. 1996 Jun 30;3(3):137-55. [Article]
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Schnier J, Isono K: The DNA sequence of the gene rpsA of Escherichia coli coding for ribosomal protein S1. Nucleic Acids Res. 1982 Mar 25;10(6):1857-65. [Article]
- Yamanaka K, Ogura T, Koonin EV, Niki H, Hiraga S: Multicopy suppressors, mssA and mssB, of an smbA mutation of Escherichia coli. Mol Gen Genet. 1994 Apr;243(1):9-16. [Article]
- Fricke J, Neuhard J, Kelln RA, Pedersen S: The cmk gene encoding cytidine monophosphate kinase is located in the rpsA operon and is required for normal replication rate in Escherichia coli. J Bacteriol. 1995 Feb;177(3):517-23. [Article]
- Schultz CP, Ylisastigui-Pons L, Serina L, Sakamoto H, Mantsch HH, Neuhard J, Barzu O, Gilles AM: Structural and catalytic properties of CMP kinase from Bacillus subtilis: a comparative analysis with the homologous enzyme from Escherichia coli. Arch Biochem Biophys. 1997 Apr 1;340(1):144-53. [Article]
- Briozzo P, Golinelli-Pimpaneau B, Gilles AM, Gaucher JF, Burlacu-Miron S, Sakamoto H, Janin J, Barzu O: Structures of escherichia coli CMP kinase alone and in complex with CDP: a new fold of the nucleoside monophosphate binding domain and insights into cytosine nucleotide specificity. Structure. 1998 Dec 15;6(12):1517-27. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02456 Aracytidine 5'-monophosphate experimental unknown Details DB02883 2',3'-Dideoxycytidine-5'-Monophosphate experimental unknown Details DB03403 Cytidine-5'-Monophosphate experimental unknown Details DB04555 Cytidine-5'-Diphosphate experimental unknown Details