N-acetylneuraminate lyase
Details
- Name
- N-acetylneuraminate lyase
- Synonyms
- 4.1.3.3
- N-acetylneuraminate pyruvate-lyase
- N-acetylneuraminic acid aldolase
- NAL
- NALase
- Sialate lyase
- Sialic acid aldolase
- Sialic acid lyase
- Gene Name
- nanA
- Organism
- Shigella flexneri
- Amino acid sequence
>lcl|BSEQ0011174|N-acetylneuraminate lyase MATNLRGVMAALLTPFDQQQALDKASLRRLVQFNIQQGIDGLYVGGSTGEAFVQSLSERE QVLEIVAEEAKGKIKLIAHVGCVSTAESQQLAASAKRYGFDAVSAVTPFYYPFSFEEHCD HYRAIIDSADGLPMVVYNIPALSGVKLTLDQINTLVTLPGVGALKQTSGDLYQMEQIRRE HPDLVLYNGYDEIFASGLLAGADGGIGSTYNIMGWRYQGIVKALKEGDIQTAQKLQTECN KVIDLLIKTGVFRGLKTVLHYMDVVSVPLCRKPFGPVDEKYLPELKALAQQLMQERG
- Number of residues
- 297
- Molecular Weight
- 32593.23
- Theoretical pI
- 5.69
- GO Classification
- FunctionsN-acetylneuraminate lyase activityProcessescarbohydrate metabolic process / N-acetylneuraminate catabolic processComponentscytoplasm
- General Function
- N-acetylneuraminate lyase activity
- Specific Function
- Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate.
- Pfam Domain Function
- DHDPS (PF00701)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011175|N-acetylneuraminate lyase (nanA) ATGGCAACGAATTTACGTGGCGTAATGGCTGCACTCCTGACTCCTTTTGATCAACAACAA GCACTGGATAAAGCGAGTCTGCGCCGCCTGGTTCAGTTCAATATTCAGCAGGGCATCGAC GGTTTATACGTGGGTGGTTCGACCGGCGAAGCCTTTGTACAAAGCCTTTCCGAGCGTGAA CAGGTACTGGAAATCGTCGCCGAAGAGGCGAAAGGTAAGATTAAACTCATCGCCCACGTC GGTTGCGTCAGCACCGCCGAAAGCCAACAACTTGCGGCATCGGCTAAACGTTATGGCTTC GATGCCGTCTCCGCCGTCACGCCGTTCTACTATCCTTTCAGCTTTGAAGAACACTGCGAT CACTATCGGGCAATTATTGATTCAGCGGATGGTTTGCCGATGGTGGTGTACAACATTCCA GCCCTGAGTGGGGTAAAACTGACCCTGGATCAGATCAACACCCTGGTTACGTTGCCTGGC GTCGGTGCGCTGAAACAGACTTCTGGCGATCTCTATCAGATGGAACAGATCCGTCGTGAA CATCCTGATCTGGTGCTCTATAACGGTTACGACGAAATCTTCGCTTCCGGCTTGCTGGCA GGCGCTGATGGTGGTATCGGCAGTACTTACAACATCATGGGCTGGCGATATCAGGGGATC GTGAAGGCGCTGAAAGAAGGCGATATCCAGACCGCGCAGAAACTGCAAACTGAGTGCAAC AAAGTCATTGATTTACTGATCAAAACGGGCGTATTCCGCGGCCTGAAAACTGTCCTGCAT TATATGGATGTCGTTTCTGTGCCGCTGTGCCGCAAACCGTTTGGACCGGTAGATGAAAAA TATCTGCCAGAACTGAAGGCGCTGGCCCAGCAGTTGATGCAAGAGCGCGGGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0A6L6 UniProtKB Entry Name NANA_SHIFL GenBank Protein ID 24053696 GenBank Gene ID AE005674 - General References
- Jin Q, Yuan Z, Xu J, Wang Y, Shen Y, Lu W, Wang J, Liu H, Yang J, Yang F, Zhang X, Zhang J, Yang G, Wu H, Qu D, Dong J, Sun L, Xue Y, Zhao A, Gao Y, Zhu J, Kan B, Ding K, Chen S, Cheng H, Yao Z, He B, Chen R, Ma D, Qiang B, Wen Y, Hou Y, Yu J: Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157. Nucleic Acids Res. 2002 Oct 15;30(20):4432-41. [Article]
- Wei J, Goldberg MB, Burland V, Venkatesan MM, Deng W, Fournier G, Mayhew GF, Plunkett G 3rd, Rose DJ, Darling A, Mau B, Perna NT, Payne SM, Runyen-Janecky LJ, Zhou S, Schwartz DC, Blattner FR: Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T. Infect Immun. 2003 May;71(5):2775-86. [Article]