Release factor glutamine methyltransferase
Details
- Name
- Release factor glutamine methyltransferase
- Synonyms
- 2.1.1.297
- hemK
- M.EcoKHemKP
- N5-glutamine methyltransferase PrmC
- Protein release factor methylation C
- Protein-(glutamine-N5) MTase PrmC
- Protein-glutamine N-methyltransferase PrmC
- RF MTase
- Gene Name
- prmC
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0004049|Release factor glutamine methyltransferase MEYQHWLREAISQLQASESPRRDAEILLEHVTGRGRTFILAFGETQLTDEQCQQLDALLT RRRDGEPIAHLTGVREFWSLPLFVSPATLIPRPDTECLVEQALARLPEQPCRILDLGTGT GAIALALASERPDCEIIAVDRMPDAVSLAQRNAQHLAIKNIHILQSDWFSALAGQQFAMI VSNPPYIDEQDPHLQQGDVRFEPLTALVAADSGMADIVHIIEQSRNALVSGGFLLLEHGW QQGEAVRQAFILAGYHDVETCRDYGDNERVTLGRYYQ
- Number of residues
- 277
- Molecular Weight
- 30974.67
- Theoretical pI
- 4.6
- GO Classification
- Functionsnucleic acid binding / protein methyltransferase activity / protein-glutamine N-methyltransferase activity / S-adenosylmethionine-dependent methyltransferase activityProcessespeptidyl-glutamine methylation / protein methylation / regulation of gene expression / translational termination
- General Function
- S-adenosylmethionine-dependent methyltransferase activity
- Specific Function
- Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif, i.e. on 'Gln-235' in RF1 and on 'Gln-252' in RF2.
- Pfam Domain Function
- Methyltransf_31 (PF13847)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0021314|Release factor glutamine methyltransferase (prmC) ATGGAATATCAACACTGGTTACGTGAAGCAATAAGCCAACTTCAGGCGAGCGAAAGCCCG CGGCGTGATGCTGAAATCCTGCTGGAGCATGTTACCGGCAGAGGGCGTACTTTTATTCTC GCCTTTGGTGAAACGCAGCTGACTGACGAACAATGTCAGCAACTTGATGCGCTACTGACA CGTCGTCGCGATGGTGAACCCATTGCTCATTTAACCGGGGTGCGAGAATTCTGGTCGTTG CCGTTATTTGTTTCGCCAGCGACCTTAATTCCGCGCCCGGATACGGAGTGTCTGGTGGAG CAGGCACTGGCGCGGTTGCCTGAACAACCTTGCCGTATTCTCGATCTCGGGACGGGTACC GGGGCGATTGCGCTTGCGCTGGCTAGCGAGCGCCCGGACTGCGAAATTATCGCTGTAGAT CGTATGCCTGATGCTGTCTCCCTGGCACAACGTAATGCCCAGCATCTGGCGATCAAAAAT ATCCACATTCTGCAAAGCGACTGGTTTAGCGCGCTAGCCGGGCAGCAGTTTGCGATGATT GTCAGCAATCCGCCGTATATTGACGAGCAGGACCCTCATCTTCAACAAGGCGATGTCCGC TTTGAGCCGCTCACTGCGCTGGTTGCGGCAGACAGTGGAATGGCAGACATCGTGCATATC ATCGAACAGTCGCGTAACGCGCTGGTATCCGGCGGCTTTCTGCTTCTGGAACATGGCTGG CAGCAGGGCGAAGCGGTGCGACAAGCATTTATCCTCGCGGGGTATCATGACGTCGAAACC TGCCGTGACTATGGTGATAACGAGCGCGTAACGCTCGGCCGCTATTATCAATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0ACC1 UniProtKB Entry Name PRMC_ECOLI GenBank Gene ID D28567 - General References
- Nakayashiki T, Nishimura K, Inokuchi H: Cloning and sequencing of a previously unidentified gene that is involved in the biosynthesis of heme in Escherichia coli. Gene. 1995 Feb 3;153(1):67-70. [Article]
- Strohmaier H, Remler P, Renner W, Hogenauer G: Expression of genes kdsA and kdsB involved in 3-deoxy-D-manno-octulosonic acid metabolism and biosynthesis of enterobacterial lipopolysaccharide is growth phase regulated primarily at the transcriptional level in Escherichia coli K-12. J Bacteriol. 1995 Aug;177(15):4488-500. [Article]
- Nakahigashi K, Kubo N, Narita S, Shimaoka T, Goto S, Oshima T, Mori H, Maeda M, Wada C, Inokuchi H: HemK, a class of protein methyl transferase with similarity to DNA methyl transferases, methylates polypeptide chain release factors, and hemK knockout induces defects in translational termination. Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1473-8. Epub 2002 Jan 22. [Article]
- Oshima T, Aiba H, Baba T, Fujita K, Hayashi K, Honjo A, Ikemoto K, Inada T, Itoh T, Kajihara M, Kanai K, Kashimoto K, Kimura S, Kitagawa M, Makino K, Masuda S, Miki T, Mizobuchi K, Mori H, Motomura K, Nakamura Y, Nashimoto H, Nishio Y, Saito N, Horiuchi T, et al.: A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map. DNA Res. 1996 Jun 30;3(3):137-55. [Article]
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Heurgue-Hamard V, Champ S, Engstrom A, Ehrenberg M, Buckingham RH: The hemK gene in Escherichia coli encodes the N(5)-glutamine methyltransferase that modifies peptide release factors. EMBO J. 2002 Feb 15;21(4):769-78. [Article]
- Yang Z, Shipman L, Zhang M, Anton BP, Roberts RJ, Cheng X: Structural characterization and comparative phylogenetic analysis of Escherichia coli HemK, a protein (N5)-glutamine methyltransferase. J Mol Biol. 2004 Jul 16;340(4):695-706. [Article]
- Graille M, Heurgue-Hamard V, Champ S, Mora L, Scrima N, Ulryck N, van Tilbeurgh H, Buckingham RH: Molecular basis for bacterial class I release factor methylation by PrmC. Mol Cell. 2005 Dec 22;20(6):917-27. [Article]