UDP-glucose 6-dehydrogenase
Details
- Name
- UDP-glucose 6-dehydrogenase
- Synonyms
- 1.1.1.22
- UDP-Glc dehydrogenase
- Gene Name
- hasB
- Organism
- Streptococcus pyogenes
- Amino acid sequence
>lcl|BSEQ0019217|UDP-glucose 6-dehydrogenase MKIAVAGSGYVGLSLGVLLSLQNEVTIVDILPSKVDKINNGLSPIQDEYIEYYLKSKQLS IKATLDSKAAYKEAELVIIATPTNYNSRINYFDTQHVETVIKEVLSVNSHATLIIKSTIP IGFITEMRQKFQTDRIIFSPEFLRESKALYDNLYPSRIIVSCEENDSPKVKADAEKFALL LKSAAKKNNVPVLIMGASEAEAVKLFANTYLALRVAYFNELDTYAESRKLNSHMIIQGIS YDDRIGMHYNNPSFGYGGYCLPKDTKQLLANYNNIPQTLIEAIVSSNNVRKSYIAKQIIN VLKEQESPVKVVGVYRLIMKSNSDNFRESAIKDVIDILKSKDIKIIIYEPMLNKLESEDQ SVLVNDLENFKKQANIIVTNRYDNELQDVKNKVYSRDIFGRD
- Number of residues
- 402
- Molecular Weight
- 45482.795
- Theoretical pI
- 8.1
- GO Classification
- FunctionsNAD binding / UDP-glucose 6-dehydrogenase activityProcessespolysaccharide biosynthetic process / UDP-glucuronate biosynthetic process
- General Function
- Udp-glucose 6-dehydrogenase activity
- Specific Function
- Catalyzes the formation of UDP-glucuronic acid which is required for capsular hyaluronic acid synthesis.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0003959|1209 bp ATGAAAATAGCAGTTGCTGGATCAGGATATGTTGGATTATCACTAGGAGTTCTTTTATCA CTTCAAAACGAAGTCACTATTGTTGATATTCTTCCCTCTAAAGTTGATAAGATTAATAAT GGCTTATCACCAATTCAAGATGAATATATTGAATATTACTTAAAAAGTAAGCAATTATCT ATTAAAGCAACTTTAGATAGCAAAGCAGCTTATAAAGAAGCGGAACTGGTCATTATTGCC ACACCTACAAATTACAACAGTAGAATTAATTATTTTGATACACAGCATGTTGAAACAGTT ATCAAAGAGGTACTAAGCGTTAATAGCCATGCAACTCTTATCATCAAATCAACAATTCCA ATAGGTTTCATTACTGAAATGAGACAGAAATTCCAAACTGATCGTATTATCTTCAGCCCT GAATTTTTAAGAGAATCTAAAGCTTTATATGACAACTTATATCCAAGCCGAATTATTGTT TCTTGTGAAGAAAACGATTCTCCAAAAGTAAAGGCAGACGCAGAAAAATTTGCACTTTTA TTAAAGTCTGCAGCTAAAAAAAATAATGTACCAGTACTTATTATGGGAGCTTCAGAAGCT GAAGCAGTAAAACTATTTGCCAATACTTATTTAGCGTTAAGGGTAGCTTATTTTAATGAG TTAGACACTTACGCAGAATCGAGAAAATTAAATAGTCACATGATTATTCAAGGAATTTCT TATGATGATCGAATAGGAATGCATTATAATAACCCATCATTTGGTTATGGAGGTTATTGT CTACCTAAAGATACGAAGCAATTATTGGCAAATTACAATAATATTCCCCAAACACTAATT GAAGCTATCGTTTCATCAAATAATGTGCGCAAGTCCTATATTGCTAAGCAAATTATCAAC GTCTTAAAAGAGCAGGAGTCCCCAGTAAAAGTAGTCGGGGTTTACCGTTTAATTATGAAA AGTAACTCAGATAACTTTAGAGAAAGTGCTATCAAAGATGTTATTGACATTCTTAAAAGT AAAGACATTAAGATAATTATTTATGAGCCAATGTTAAACAAACTTGAATCTGAAGATCAA TCTGTACTTGTAAATGATTTAGAGAATTTCAAGAAACAAGCAAATATTATCGTAACTAAT CGCTATGATAATGAATTACAAGATGTTAAAAATAAAGTTTACAGTAGAGATATTTTTGGT AGAGACTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0C0F4 UniProtKB Entry Name UDG_STRPY GenBank Protein ID 295189 GenBank Gene ID L08444 - General References
- Dougherty BA, van de Rijn I: Molecular characterization of hasB from an operon required for hyaluronic acid synthesis in group A streptococci. Demonstration of UDP-glucose dehydrogenase activity. J Biol Chem. 1993 Apr 5;268(10):7118-24. [Article]
- Ge X, Penney LC, van de Rijn I, Tanner ME: Active site residues and mechanism of UDP-glucose dehydrogenase. Eur J Biochem. 2004 Jan;271(1):14-22. [Article]
- Campbell RE, Mosimann SC, van De Rijn I, Tanner ME, Strynadka NC: The first structure of UDP-glucose dehydrogenase reveals the catalytic residues necessary for the two-fold oxidation. Biochemistry. 2000 Jun 13;39(23):7012-23. [Article]