Hemagglutinin-neuraminidase
Details
- Name
- Hemagglutinin-neuraminidase
- Synonyms
- 3.2.1.18
- Gene Name
- HN
- Organism
- HPIV-3
- Amino acid sequence
>lcl|BSEQ0019170|Hemagglutinin-neuraminidase MEYWKHTNHGKDAGNELETSMATHGNKLTNKIIYILWTIILVLLSIVFIIVLINSIKSEK AHESLLRDINNEFMEITGKIQMASDNTNDLIQSGVNTRLLTIQSHVQNYIPISLTQQMSD LRKFISEITIRNDNQEVLPQRITHDVGIKPLNPDDFWRCTSGLPSLMKTPKIRLMPGPGL LAMPTTDDGCIRTPSLVINDLIYAYTSNLITRGCQDIGKSYQVLQIGIITVNSDLVPDLN PRISHTFNINDNRKSCSLALLNTDVYQLCSTPKVDERSDYASSGIEDIVLDIVNYDGSIS TTRFKNNNISFDQPYAALYPSVGPGIYYKGKIIFLGYGGLEHPINENVICNTTGCPGKTQ RDCNQASHSPWFSDRRMVNSIIVVDKGLNSTPKLKVWTISMRQNYWGSEGRLLLLGNKIY IYTRSTSWHSKLQLGIIDITDYSDIRIKWTWHNVLSRPGNNECPWGHSCPDGCITGVYTD AYPLNPTGSIVSSVILDSQKSRVNPVITYSTATERVNELAIRNRTLSAGYTTTSCITHYN KGYCFHIVEINHKSLNTFQPMLFKTEIPKSCS
- Number of residues
- 572
- Molecular Weight
- 64329.845
- Theoretical pI
- 7.96
- GO Classification
- Functionsexo-alpha-(2->3)-sialidase activity / exo-alpha-(2->6)-sialidase activity / exo-alpha-(2->8)-sialidase activityProcessesviral entry into host cell / virion attachment to host cellComponentshost cell plasma membrane / integral component of membrane / viral envelope / virion membrane
- General Function
- Exo-alpha-(2->8)-sialidase activity
- Specific Function
- Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
- Pfam Domain Function
- HN (PF00423)
- Transmembrane Regions
- 32-52
- Cellular Location
- Virion membrane
- Gene sequence
>lcl|BSEQ0003418|1719 bp ATGGAATACTGGAAGCATACCAATCACGGAAAGGATGCTGGTAATGAGCTGGAGACGTCC ATGGCTACTCATGGCAACAAGCTCACTAATAAGATAATATACATATTATGGACAATAATC CTGGTGTTATTATCAATAGTCTTCATCATAGTGCTAATCAATTCCATCAAAAGTGAAAAG GCCCACGAATCATTGCTGCGAGACATAAACAATGAGTTTATGGAAATTACAGGAAAGATC CAAATGGCATCGGATAATACCAATGATCTAATACAGTCAGGAGTGAATACAAGGCTTCTT ACAATTCAGAGTCATGTCCAGAATTACATACCAATATCATTGACACAACAGATGTCAGAT CTTAGGAAATTCATTAGTGAAATTACAATTAGAAATGATAATCAAGAAGTGCTGCCGCAA AGAATAACACATGATGTAGGTATAAAACCTTTAAATCCAGATGATTTTTGGAGATGCACG TCTGGTCTTCCATCTTTAATGAAAACTCCAAAAATAAGGTTAATGCCAGGGCCGGGGTTA TTAGCTATGCCAACGACTGATGATGGCTGTATTAGAACTCCGTCTTTAGTTATAAATGAT CTGATTTATGCTTATACCTCAAATCTAATTACTCGAGGTTGTCAGGATATAGGAAAATCA TATCAAGTCTTACAGATAGGGATAATAACTGTAAACTCAGACTTGGTACCTGACTTAAAT CCTAGGATCTCTCATACTTTCAACATAAATGACAATAGGAAGTCATGCTCTCTAGCACTC CTAAATACAGATGTATATCAACTGTGTTCAACTCCCAAAGTTGATGAAAGATCAGATTAT GCATCATCAGGCATAGAAGATATTGTACTTGATATTGTCAATTATGATGGCTCAATCTCA ACAACAAGATTTAAGAATAATAACATAAGCTTTGATCAACCATATGCTGCGCTATACCCA TCTGTTGGACCAGGGATATACTACAAAGGCAAAATAATATTTCTCGGATATGGAGGTCTT GAACATCCAATAAATGAGAATGTAATCTGCAATACAACTGGGTGTCCCGGGAAAACACAG AGAGACTGTAATCAAGCGTCTCATAGTCCATGGTTTTCAGATAGGAGGATGGTCAACTCC ATCATTGTTGTTGACAAAGGCTTAAACTCAACTCCAAAATTGAAGGTATGGACGATATCT ATGCGACAAAATTACTGGGGGTCAGAAGGAAGGTTACTTCTACTAGGTAACAAGATCTAT ATATATACAAGATCTACAAGTTGGCATAGCAAGTTACAATTAGGAATAATTGATATTACT GATTACAGTGATATAAGGATAAAATGGACATGGCATAATGTGCTATCAAGACCAGGAAAC AATGAATGTCCATGGGGACATTCATGTCCAGATGGATGTATAACAGGAGTATATACTGAT GCATATCCACTCAATCCCACAGGGAGCATTGTGTCATCTGTCATATTAGACTCACAAAAA TCGAGAGTGAACCCAGTCATAACTTACTCAACAGCAACCGAAAGAGTAAACGAGCTGGCC ATCCGAAACAGAACACTCTCAGCTGGATATACAACAACAAGCTGCATTACACACTATAAC AAAGGATATTGTTTTCATATAGTAGAAATAAATCATAAAAGCTTAAACACATTTCAACCC ATGTTGTTCAAAACAGAGATTCCAAAAAGCTGCAGTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P12564 UniProtKB Entry Name HN_PI3HV GenBank Protein ID 332715 GenBank Gene ID M18764 - General References
- van Wyke Coelingh KL, Winter CC, Murphy BR: Nucleotide and deduced amino acid sequence of hemagglutinin-neuraminidase genes of human type 3 parainfluenza viruses isolated from 1957 to 1983. Virology. 1988 Jan;162(1):137-43. [Article]