Genome polyprotein
Details
- Name
- Genome polyprotein
- Synonyms
- 3.4.21.91
- NS1
- Gene Name
- Not Available
- Organism
- DENV-2
- Amino acid sequence
>lcl|BSEQ0010881|Genome polyprotein MNDQRKKARNTPFNMLKRERNRVSTVQQLTKRFSLGMLQGRGPLKLFMALVAFLRFLTIP PTAGILKRWGTIKKSKAINVLRGFRKEIGRMLNILNRRRRTAGMIIMLIPTVMAFHLTTR NGEPHMIVSRQEKGKSLLFKTKDGTNMCTLMAMDLGELCEDTITYKCPFLKQNEPEDIDC WCNSTSTWVTYGTCTTTGEHRREKRSVALVPHVGMGLETRTETWMSSEGAWKHAQRIETW ILRHPGFTIMAAILAYTIGTTHFQRVLIFILLTAIAPSMTMRCIGISNRDFVEGVSGGSW VDIVLEHGSCVTTMAKNKPTLDFELIKTEAKQPATLRKYCIEAKLTNTTTDSRCPTQGEP TLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKIVQPENLEYTVV ITPHSGEEHAVGNDTGKHGKEVKITPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLLQ MKDKAWLVHRQWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAM HTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVKEIAETQHGTI VIRVQYEGDGSPCKTPFEIMDLEKRHVLGRLTTVNPIVTEKDSPVNIEAEPPFGDSYIII GVEPGQLKLDWFKKGSSIGQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVF GAIYGAAFSGVSWTMKILIGVIITWIGMNSRSTSLSVSLVLVGIVTLYLGVMVQADSGCV VSWKNKELKCGSGIFVTDNVHTWTEQYKFQPESPSKLASAIQKAHEEGICGIRSVTRLEN LMWKQITSELNHILSENEVKLTIMTGDIKGIMQVGKRSLRPQPTELRYSWKTWGKAKMLS TELHNQTFLIDGPETAECPNTNRAWNSLEVEDYGFGVFTTNIWLRLREKQDAFCDSKLMS AAIKDNRAVHADMGYWIESALNDTWKIEKASFIEVKSCHWPKSHTLWSNGVLESEMVIPK NFAGPVSQHNNRPGYHTQTAGPWHLGKLEMDFDFCEGTTVVVTEDCGNRGPSLRTTTASG KLITEWCCRSCTLPPLRYRGEDGCWYGMEIRPLKEKEENLVSSLVTAGHGQIDNFSLGIL GMALFLEEMLRTRVGTKHAILLVAVSFVTLITGNMSFRDLGRVMVMVGATMTDDIGMGVT YLALLAAFKVRPTFAAGLLLRKLTSKELMMTTIGIVLLSQSSIPETILELTDALALGMMV LKMVRNMEKYQLAVTIMAILCVPNAVILQNAWKVSCTILAVVSVSPLFLTSSQQKADWIP LALTIKGLNPTAIFLTTLSRTSKKRSWPLNEAIMAVGMVSILASSLLKNDTPMTGPLVAG GLLTVCYVLTGRSADLELERATDVKWDDQAEISGSSPILSITISEDGSMSIKNEEEEQTL TILIRTGLLVISGLFPVSIPITAAAWYLWEVKKQRAGVLWDVPSPPPVGKAELEDGAYRI KQKGILGYSQIGAGVYKEGTFHTMWHVTRGAVLMHKGKRIEPSWADVKKDLISYGGGWKL EGEWKEGEEVQVLALEPGKNPRAVQTKPGLFRTNTGTIGAVSLDFSPGTSGSPIVDKKGK VVGLYGNGVVTRSGAYVSAIAQTEKSIEDNPEIEDDIFRKRRLTIMDLHPGAGKTKRYLP AIVREAIKRGLRTLILAPTRVVAAEMEEALRGLPIRYQTPAIRAEHTGREIVDLMCHATF TMRLLSPIRVPNYNLIIMDEAHFTDPASIAARGYISTRVEMGEAAGIFMTATPPGSRDPF PQSNAPIMDEEREIPERSWNSGHEWVTDFKGKTVWFVPSIKTGNDIAACLRKNGKRVIQL SRKTFDSEYVKTRTNDWDFVVTTDISEMGANFKAERVIDPRRCMKPVILTDGEERVILAG PMPVTHSSAAQRRGRIGRNPRNENDQYIYMGEPLENDEDCAHWKEAKMLLDNINTPEGII PSMFEPEREKVDAIDGEYRLRGEARKTFVDLMRRGDLPVWLAYKVAAEGINYADRRWCFD GTRNNQILEENVEVEIWTKEGERKKLKPRWLDARIYSDPLALKEFAAGRKSLTLNLITEM GRLPTFMTQKARDALDNLAVLHTAEAGGKAYNHALSELPETLETLLLLTLLATVTGGIFL FLMSGRGIGKMTLGMCCIITASILLWYAQIQPHWIAASIILEFFLIVLLIPEPEKQRTPQ DNQLTYVIIAILTVVAATMANEMGFLEKTKKDLGLGNIATQQPESNILDIDLRPASAWTL YAVATTFITPMLRHSIENSSVNVSLTAIANQATVLMGLGKGWPLSKMDIGVPLLAIGCYS QVNPITLTAALLLLVAHYAIIGPGLQAKATREAQKRAAAGIMKNPTVDGITVIDLDPIPY DPKFEKQLGQVMLLVLCVTQVLMMRTTWALCEALTLATGPVSTLWEGNPGRFWNTTIAVS MANIFRGSYLAGAGLLFSIMKNTTSTRRGTGNIGETLGEKWKSRLNALGKSEFQIYKKSG IQEVDRTLAKEGIKRGETDHHAVSRGSAKLRWFVERNLVTPEGKVVDLGCGRGGWSYYCG GLKNVREVKGLTKGGPGHEEPIPMSTYGWNLVRLQSGVDVFFVPPEKCDTLLCDIGESSP NPTVEAGRTLRVLNLVENWLNNNTQFCVKVLNPYMPSVIERMETLQRKYGGALVRNPLSR NSTHEMYWVSNASGNIVSSVNMISRMLINRFTMRHKKATYEPDVDLGSGTRNIGIESETP NLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPW DVVPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPR MCTREEFTKKVRSNAALGAIFTDENKWKSAREAVEDSRFWELVDKERNLHLEGKCETCVY NMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGL HKLGYILREVSKKEGGAMYADDTAGWDTRITIEDLKNEEMITNHMAGEHKKLAEAIFKLT YQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVGTYGLNTFTNMEAQLIRQMEGEGIFKSI QHLTASEEIAVQDWLARVGRERLSRMAISGDDCVVKPLDDRFARALTALNDMGKVRKDIQ QWEPSRGWNDWTQVPFCSHHFHELIMKDGRTLVVPCRNQDELIGRARISQGAGWSLRETA CLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHASHEWMTTEDMLTV WNKVWILENPWMEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRS LIGNEEYTDYMPSMKRFRREEEEAGVLW
- Number of residues
- 3388
- Molecular Weight
- 379216.195
- Theoretical pI
- 8.67
- GO Classification
- FunctionsATP binding / ATP-dependent helicase activity / double-stranded RNA binding / metal ion binding / mRNA (guanine-N7-)-methyltransferase activity / mRNA (nucleoside-2'-O-)-methyltransferase activity / RNA helicase activity / RNA-directed RNA polymerase activity / serine-type endopeptidase activity / serine-type exopeptidase activity / structural molecule activityProcessesclathrin-mediated endocytosis of virus by host cell / fusion of virus membrane with host endosome membrane / induction by virus of host autophagy / regulation of transcription, DNA-templated / suppression by virus of host STAT2 activity / suppression by virus of host TYK2 activity / suppression by virus of host type I interferon-mediated signaling pathway / transcription, DNA-templated / viral RNA genome replication / virion attachment to host cellComponentsextracellular region / host cell endoplasmic reticulum membrane / host cell nucleus / integral component of membrane / viral capsid / viral envelope / virion membrane
- General Function
- Structural molecule activity
- Specific Function
- Capsid protein C self-assembles to form an icosahedral capsid about 30 nm in diameter. The capsid encapsulates the genomic RNA.prM acts as a chaperone for envelope protein E during intracellular virion assembly by masking and inactivating envelope protein E fusion peptide. prM is matured in the last step of virion assembly, presumably to avoid catastrophic activation of the viral fusion peptide induced by the acidic pH of the trans-Golgi network. After cleavage by host furin, the pr peptide is released in the extracellular medium and small envelope protein M and envelope protein E homodimers are dissociated.Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes.Non-structural protein 1 is involved in virus replication and regulation of the innate immune response. Soluble and membrane-associated NS1 may activate human complement and induce host vascular leakage. This effect might explain the clinical manifestations of dengue hemorrhagic fever and dengue shock syndrome.Non-structural protein 2A may be involved viral RNA replication and capsid assembly.Non-structural protein 2B is a required cofactor for the serine protease function of NS3.Serine protease NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS2B, performs its autocleavage and cleaves the polyprotein at dibasic sites in the cytoplasm: C-prM, NS2A-NS2B, NS2B-NS3, NS3-NS4A, NS4A-2K and NS4B-NS5. NS3 RNA helicase binds RNA and unwinds dsRNA in the 3' to 5' direction (By similarity).Non-structural protein 4A induces host endoplasmic reticulum membrane rearrangements leading to the formation of virus-induced membranous vesicles hosting the dsRNA and polymerase, functioning as a replication complex. NS4A might also regulate the ATPase activity of the NS3 helicase.Peptide 2k functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.Non-structural protein 4B inhibits interferon (IFN)-induced host STAT1 phosphorylation and nuclear translocation, thereby preventing the establishment of cellular antiviral state by blocking the IFN-alpha/beta pathway.RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions. Besides its role in genome replication, also prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) signaling pathway. Inhibits host TYK2 and STAT2 phosphorylation, thereby preventing activation of JAK-STAT signaling pathway (By similarity).
- Pfam Domain Function
- Transmembrane Regions
- 102-122 239-259 266-280 1125-1145 1157-1177 1185-1205 1272-1292 1318-1338 1347-1367 1371-1391 2145-2165 2190-2210 2226-2246 2345-2365 2411-2431 2457-2477
- Cellular Location
- Virion
- Gene sequence
>lcl|BSEQ0002509|10167 bp ATGAATGACCAACGGAAAAAGGCGAGAAACACGCCTTTCAATATGCTGAAACGCGAGAGA AACCGCGTGTCAACTGTACAACAGTTGACAAAGAGATTCTCACTTGGAATGCTGCAGGGA CGAGGACCACTAAAATTGTTCATGGCCCTGGTGGCATTCCTTCGTTTCCTAACAATCCCA CCAACAGCAGGGATATTAAAAAGATGGGGAACAATTAAAAAATCAAAGGCTATTAATGTT CTGAGAGGCTTCAGGAAAGAGATTGGAAGGATGCTGAATATCTTAAACAGGAGACGTAGA ACTGCAGGCATGATCATCATGCTGATTCCAACAGTGATGGCGTTTCATCTGACCACACGC AACGGAGAACCACACATGATCGTCAGTAGACAAGAAAAAGGGAAAAGCCTTCTGTTTAAG ACAAAGGACGGCACGAACATGTGTACCCTCATGGCCATGGACCTTGGTGAGTTGTGTGAA GACACAATCACGTATAAATGTCCCTTTCTCAAGCAGAACGAACCAGAAGACATAGATTGT TGGTGCAACTCCACGTCCACATGGGTAACTTATGGGACATGTACCACCACAGGAGAGCAC AGAAGAGAAAAAAGATCAGTGGCGCTTGTTCCACACGTGGGAATGGGATTGGAGACACGA ACTGAAACATGGATGTCATCAGAAGGGGCCTGGAAACATGCCCAGAGAATTGAAACTTGG ATTCTGAGACATCCAGGCTTTACCATAATGGCCGCAATCCTGGCATACACCATAGGAACG ACGCATTTCCAAAGAGTCCTGATATTCATCCTACTGACAGCCATCGCTCCTTCAATGACA ATGCGCTGCATAGGAATATCAAATAGGGACTTTGTGGAAGGAGTGTCAGGAGGGAGTTGG GTTGACATAGTTTTAGAACATGGAAGTTGTGTGACGACGATGGCAAAAAATAAACCAACA CTGGACTTTGAACTGATAAAAACAGAAGCCAAACAACCCGCCACCTTAAGGAAGTACTGT ATAGAGGCTAAACTGACCAACACGACAACAGACTCGCGCTGCCCAACACAAGGGGAACCC ACCCTGAATGAAGAGCAGGACAAAAGGTTTGTCTGCAAACATTCCATGGTAGACAGAGGA TGGGGAAATGGATGTGGATTATTTGGAAAAGGAGGCATCGTGACCTGTGCCATGTTCACA TGCAAAAAGAACATGGAGGGAAAAATTGTGCAGCCAGAAAACCTGGAATACACTGTCGTT ATAACACCTCATTCAGGGGAAGAACATGCAGTCGGAAATGACACAGGAAAACATGGTAAA GAAGTCAAGATAACACCACAGAGCTCCATCACAGAGGCGGAACTGACAGGCTATGGCACT GTTACGATGGAGTGCTCTCCAAGAACGGGCCTCGACTTCAATGAGATGGTGTTGCTGCAA ATGAAAGACAAAGCTTGGCTGGTGCACAGACAATGGTTCCTAGACCTACCGTTGCCATGG CTGCCCGGAGCAGACACACAAGGATCAAATTGGATACAGAAAGAGACACTGGTCACCTTC AAAAATCCCCATGCGAAAAAACAGGATGTTGTTGTCTTAGGATCCCAAGAGGGGGCCATG CATACAGCACTCACAGGGGCTACGGAAATCCAGATGTCATCAGGAAACCTGCTGTTCACA GGACATCTTAAGTGCAGGCTGAGAATGGACAAATTACAACTTAAAGGGATGTCATACTCC ATGTGCACAGGAAAGTTTAAAGTTGTGAAGGAAATAGCAGAAACACAACATGGAACAATA GTCATTAGAGTACAATATGAAGGAGACGGCTCTCCATGCAAGACCCCTTTTGAGATAATG GATCTGGAAAAAAGACATGTTTTGGGCCGCCTGACCACAGTCAACCCAATTGTAACAGAA AAGGACAGTCCAGTCAACATAGAAGCAGAACCTCCATTCGGAGACAGCTACATCATCATA GGAGTGGAACCAGGACAATTGAAGCTGGACTGGTTCAAGAAAGGAAGTTCCATCGGCCAA ATGTTTGAGACAACAATGAGGGGAGCGAAAAGAATGGCCATTTTGGGCGACACAGCCTGG GATTTTGGATCTCTGGGAGGAGTGTTCACATCAATAGGAAAGGCTCTCCACCAGGTTTTT GGAGCAATCTACGGGGCTGCTTTCAGTGGGGTCTCATGGACTATGAAGATCCTCATAGGA GTTATCATCACATGGATAGGAATGAACTCACGTAGCACATCACTGTCTGTGTCACTGGTA TTAGTGGGAATCGTGACACTGTACTTGGGAGTTATGGTGCAGGCCGATAGTGGTTGCGTT GTGAGCTGGAAGAACAAAGAACTAAAATGTGGCAGTGGAATATTCGTCACAGATAACGTG CATACATGGACAGAACAATACAAGTTCCAACCAGAATCCCCTTCAAAACTGGCTTCAGCC ATCCAGAAAGCTCATGAAGAGGGCATCTGTGGAATCCGCTCAGTAACAAGACTGGAAAAT CTTATGTGGAAACAAATAACATCAGAATTGAATCATATTCTATCAGAAAATGAAGTGAAA CTGACCATCATGACAGGAGACATCAAAGGAATCATGCAGGTAGGAAAACGATCTCTGCGG CCTCAACCCACTGAGTTGAGGTATTCATGGAAAACATGGGGTAAAGCGAAAATGCTCTCC ACAGAACTCCATAATCAGACCTTCCTCATTGATGGTCCCGAAACAGCAGAATGCCCCAAC ACAAACAGAGCTTGGAATTCACTAGAAGTTGAGGACTACGGCTTTGGAGTATTCACTACC AATATATGGCTAAGATTGAGAGAAAAGCAGGATGCATTTTGTGACTCAAAACTCATGTCA GCGGCCATAAAGGACAACAGAGCCGTCCATGCTGATATGGGTTATTGGATAGAAAGCGCA CTCAATGATACATGGAAGATAGAGAAAGCTTCTTTCATTGAAGTCAAAAGTTGCCACTGG CCAAAGTCACACACTCTATGGAGTAATGGAGTGCTAGAAAGCGAGATGGTAATTCCAAAG AATTTCGCTGGACCAGTGTCACAACATAATAACAGACCAGGCTATCACACACAAACAGCA GGACCTTGGCATCTAGGCAAGCTTGAGATGGACTTTGATTTCTGCGAAGGGACTACAGTG GTGGTAACCGAGGACTGTGGAAACAGAGGGCCCTCTTTAAGAACAACCACTGCCTCAGGA AAACTCATAACGGAATGGTGTTGTCGATCTTGCACACTACCACCACTAAGATACAGAGGT GAGGATGGATGCTGGTACGGGATGGAAATCAGACCATTGAAAGAGAAAGAAGAAAATCTG GTCAGTTCTCTGGTCACAGCCGGACATGGGCAGATTGATAATTTCTCATTAGGAATCTTG GGAATGGCACTGTTCCTTGAAGAAATGCTCAGGACTCGAGTAGGAACGAAACATGCAATA TTACTAGTCGCAGTTTCTTTCGTAACGTTAATCACAGGGAACATGTCTTTTAGAGACCTG GGAAGAGTGATGGTTATGGTGGGTGCCACCATGACAGATGACATAGGCATGGGTGTGACT TATCTTGCTCTACTAGCAGCTTTCAAAGTCAGACCAACCTTTGCAGCTGGACTGCTCTTG AGAAAACTGACCTCCAAGGAATTAATGATGACCACCATAGGAATCGTTCTTCTCTCCCAG AGTAGCATACCAGAGACCATTCTTGAACTGACCGATGCGTTAGCTTTAGGCATGATGGTC CTCAAGATGGTGAGAAACATGGAAAAATATCAGCTGGCAGTGACCATCATGGCTATTTTG TGCGTCCCAAATGCTGTGATATTACAGAACGCATGGAAAGTGAGTTGCACAATATTGGCA GTGGTGTCTGTTTCCCCCCTGTTCTTAACATCCTCACAACAGAAAGCGGACTGGATACCA TTAGCGTTGACGATCAAAGGCCTCAATCCAACAGCCATTTTTCTAACAACCCTCTCAAGA ACCAGCAAGAAAAGGAGCTGGCCTTTAAATGAGGCCATCATGGCGGTTGGGATGGTGAGT ATCTTGGCCAGCTCTCTCTTAAAGAATGACACCCCCATGACAGGACCATTAGTGGCTGGA GGGCTTCTTACTGTGTGCTACGTACTAACTGGGCGGTCAGCCGATCTGGAACTAGAGAGA GCTACCGATGTCAAATGGGATGACCAGGCAGAGATATCAGGTAGCAGTCCAATTCTGTCA ATAACAATATCAGAAGATGGCAGCATGTCAATAAAGAATGAAGAGGAAGAGCAAACATTG ACTATACTCATTAGAACAGGATTGCTTGTGATCTCAGGACTCTTTCCGGTATCAATACCA ATTACAGCAGCAGCATGGTACCTGTGGGAAGTAAAGAAACAACGGGCTGGAGTGTTGTGG GATGTCCCCTCACCACCACCCGTGGGAAAGGCTGAATTGGAAGATGGAGCCTACAGAATC AAGCAAAAAGGAATCCTTGGATATTCCCAGATCGGAGCTGGAGTTTACAAAGAAGGAACA TTTCACACAATGTGGCACGTCACACGTGGCGCTGTCCTAATGCATAAGGGGAAGAGGATT GAACCATCATGGGCGGACGTCAAGAAAGACTTAATATCATATGGAGGAGGTTGGAAGCTA GAAGGAGAATGGAAAGAAGGAGAAGAAGTCCAGGTCTTGGCATTGGAGCCTGGGAAAAAT CCAAGAGCCGTCCAAACAAAACCTGGCCTTTTTAGAACCAATACTGGAACCATAGGTGCC GTATCTCTGGACTTTTCCCCTGGGACGTCAGGATCTCCAATCGTCGACAAAAAAGGAAAA GTTGTAGGCCTCTATGGCAATGGTGTCGTTACAAGGAGTGGAGCATATGTGAGTGCCATA GCTCAGACTGAAAAAAGCATTGAAGACAATCCAGAGATTGAAGATGACATCTTTCGAAAG AGAAGATTGACTATCATGGATCTCCACCCAGGAGCAGGAAAGACAAAGAGATACCTCCCG GCCATAGTCAGAGAGGCCATAAAAAGAGGCTTGAGAACACTAATCCTAGCCCCCACTAGA GTCGTGGCAGCTGAAATGGAGGAAGCCCTTAGAGGACTTCCAATAAGATACCAAACTCCA GCTATCAGGGCTGAGCACACCGGGCGGGAGATTGTGGACTTAATGTGTCATGCCACATTT ACCATGAGGCTGCTATCACCAATCAGGGTGCCAAATTACAACCTGATCATCATGGACGAA GCCCATTTTACAGATCCAGCAAGCATAGCAGCTAGGGGATACATCTCAACTCGAGTGGAG ATGGGTGAGGCAGCTGGAATTTTTATGACAGCCACTCCTCCGGGTAGCAGAGATCCATTT CCTCAGAGTAATGCACCAATTATGGACGAAGAAAGAGAAATCCCGGAACGTTCATGGAAC TCCGGGCACGAGTGGGTCACGGATTTTAAAGGAAAGACTGTCTGGTTTGTTCCAAGCATA AAAACCGGAAATGACATAGCAGCCTGCCTGAGAAAGAATGGAAAGAGGGTGATACAACTC AGTAGGAAGACCTTTGATTCTGAATATGTCAAGACTAGAACCAATGACTGGGATTTCGTG GTTACAACTGACATCTCGGAAATGGGTGCCAACTTTAAAGCTGAGAGGGTTATAGACCCC AGACGCTGCATGAAACCAGTTATACTGACAGACGGCGAAGAGCGGGTGATTCTGGCAGGA CCCATGCCAGTGACCCACTCTAGTGCAGCACAAAGAAGAGGGAGAATAGGAAGGAATCCA AGGAATGAAAATGATCAATATATATATATGGGGGAACCCCTGGAAAATGATGAAGACTGT GCGCACTGGAAGGAAGCTAAGATGCTCCTAGATAACATCAACACACCTGAAGGAATCATT CCCAGCATGTTCGAGCCAGAGCGTGAAAAGGTGGATGCCATTGACGGTGAATATCGCTTG AGAGGAGAAGCACGGAAAACTTTTGTGGACCTAATGAGAAGAGGAGACCTACCAGTCTGG TTGGCTTATAAAGTGGCTGCTGAAGGTATCAACTACGCAGACAGAAGATGGTGTTTTGAC GGAACCAGAAACAATCAAATCTTGGAAGAAAATGTGGAAGTGGAAATCTGGACAAAGGAA GGGGAAAGGAAAAAATTGAAACCTAGATGGTTAGATGCTAGGATCTACTCCGACCCACTG GCGCTAAAAGAATTCGCAGCCGGAAGAAAGTCCCTAACCCTGAACCTAATCACAGAGATG GGCAGACTCCCAACTTTTATGACTCAGAAGGCCAGAGATGCACTAGACAACTTGGCGGTG CTGCACACGGCTGAAGCGGGTGGAAAGGCATACAATCATGCTCTCAGTGAACTACCGGAG ACCCTGGAGACATTGCTTTTGCTGACACTGTTGGCCACAGTCACGGGAGGAATCTTTCTA TTCCTGATGAGCGGAAGGGGTATAGGGAAGATGACCCTGGGAATGTGCTGCATAATCACG GCCAGCATCCTCTTATGGTATGCACAAATACAACCACATTGGATAGCAGCTTCAATAATA TTGGAGTTCTTTCTCATAGTCTTGCTCATTCCAGAACCAGAAAAGCAGAGGACACCCCAG GATAACCAATTGACTTATGTCATCATAGCCATCCTCACAGTGGTGGCCGCAACCATGGCA AACGAAATGGGTTTTCTGGAAAAAACAAAGAAAGACCTCGGACTGGGAAACATTGCAACT CAGCAACCTGAGAGCAACATTCTGGACATAGATCTACGTCCTGCATCAGCATGGACGTTG TATGCCGTGGCCACAACATTTATCACACCAATGTTGAGACATAGCATTGAAAATTCCTCA GTAAATGTGTCCCTAACAGCCATAGCTAACCAAGCCACAGTGCTAATGGGTCTCGGGAAA GGATGGCCATTGTCAAAGATGGACATTGGAGTTCCCCTCCTTGCTATTGGGTGTTACTCA CAAGTCAACCCTATAACCCTCACAGCGGCTCTTCTTTTATTGGTAGCACATTATGCCATC ATAGGACCGGGACTTCAAGCCAAAGCAACCAGAGAAGCTCAGAAAAGAGCAGCAGCGGGC ATCATGAAAAACCCAACTGTGGATGGAATAACAGTGATAGATCTAGATCCAATACCCTAT GATCCAAAGTTTGAAAAGCAGTTGGGACAAGTAATGCTCCTAGTCCTCTGTGTGACCCAA GTGCTGATGATGAGGACTACGTGGGCTTTGTGTGAAGCCTTAACTCTAGCAACCGGACCC GTGTCCACATTGTGGGAAGGAAATCCAGGGAGATTCTGGAACACAACCATTGCAGTGTCA ATGGCAAACATCTTTAGAGGGAGTTACCTGGCTGGAGCTGGACTTCTCTTTTCTATCATG AAGAACACAACCAGCACGAGAAGAGGAACTGGCAACATAGGAGAAACGCTAGGAGAGAAA TGGAAAAGCAGGCTGAACGCATTGGGGAAAAGTGAATTCCAGATCTATAAAAAAAGTGGA ATTCAAGAAGTGGACAGAACCTTAGCAAAAGAAGGCATTAAAAGAGGAGAAACGGATCAT CACGCTGTGTCGCGAGGCTCAGCAAAACTGAGATGGTTCGTTGAAAGAAATTTGGTCACA CCAGAAGGGAAAGTAGTGGACCTTGGTTGCGGCAGAGGGGGCTGGTCATACTATTGTGGA GGATTAAAGAATGTAAGAGAAGTCAAAGGCTTAACAAAAGGAGGACCAGGACACGAAGAA CCTATCCCTATGTCAACATATGGGTGGAATCTAGTACGCTTACAGAGCGGAGTTGACGTT TTTTTTGTTCCACCAGAGAAGTGTGACACATTGTTGTGTGACATAGGGGAATCATCACCA AATCCCACGGTAGAAGCGGGACGAACACTCAGAGTCCTTAACCTAGTGGAAAATTGGTTG AACAATAACACCCAATTTTGCGTAAAGGTTCTTAACCCGTACATGCCCTCAGTCATTGAA AGAATGGAAACCTTACAACGGAAATACGGAGGAGCCTTGGTGAGAAATCCACTCTCACGG AATTCCACACATGAGATGTACTGGGTGTCCAATGCTTCCGGGAACATAGTGTCATCAGTG AACATGATTTCAAGAATGCTGATTAACAGATTCACCATGAGACACAAGAAGGCCACCTAT GAGCCAGATGTCGACCTCGGAAGCGGAACCCGCAATATTGGAATTGAAAGTGAGACACCG AACCTAGACATAATTGGGAAAAGAATAGAAAAAATAAAACAAGAGCATGAAACGTCATGG CACTATGACCAAGACCACCCATACAAAACATGGGCTTACCATGGCAGCTATGAAACAAAA CAGACTGGATCAGCATCATCCATGGTGAACGGAGTAGTCAGATTGCTGACAAAACCCTGG GACGTTGTTCCAATGGTGACACAGATGGCAATGACAGACACAACTCCTTTCGGACAACAG CGCGTCTTCAAAGAGAAGGTGGATACGAGAACCCAAGAACCAAAAGAAGGCACAAAAAAA CTAATGAAAATCACGGCAGAGTGGCTCTGGAAAGAACTAGGAAAGAAAAAGACACCTAGA ATGTGCACCAGAGAAGAATTCACAAAAAAGGTGAGAAGCAATGCAGCCTTGGGGGCCATA TTTACCGATGAGAACAAGTGGAAATCGGCGCGTGAGGCTGTTGAAGATAGTAGGTTTTGG GAGCTGGTTGACAAGGAAAGAAACCTCCATCTTGAAGGGAAATGTGAAACATGTGTATAC AACATGATGGGAAAAAGAGAGAAAAAACTAGGAGAGTTTGGTAAAGCAAAAGGCAGCAGA GCCATATGGTACATGTGGCTCGGAGCACGCTTCTTAGAGTTCGAAGCCCTAGGATTTTTG AATGAAGACCATTGGTTCTCCAGAGAGAACTCCCTGAGTGGAGTAGAAGGAGAAGGGCTG CATAAGCTAGGTTACATCTTAAGAGAGGTGAGCAAGAAAGAAGGAGGAGCAATGTATGCC GATGACACCGCAGGCTGGGACACAAGAATCACAATAGAGGATTTAAAAAATGAAGAAATG ATAACGAACCACATGGCAGGAGAACACAAGAAACTTGCCGAGGCCATTTTTAAATTGACG TATCAAAACAAGGTGGTGCGTGTGCAAAGACCAACACCAAGAGGCACAGTAATGGACATC ATATCGAGAAGAGACCAAAGGGGTAGTGGACAAGTTGGTACCTATGGCCTCAACACTTTC ACCAACATGGAAGCACAACTAATTAGGCAAATGGAGGGGGAAGGAATCTTCAAAAGCATC CAGCACTTGACAGCCTCAGAAGAAATCGCTGTGCAAGATTGGCTAGCAAGAGTAGGGCGT GAAAGGTTGTCAAGAATGGCCATCAGTGGAGATGATTGTGTTGTGAAACCTTTAGATGAT AGATTTGCAAGAGCTCTAACAGCTCTAAATGACATGGGAAAGGTTAGGAAGGACATACAG CAATGGGAGCCCTCAAGAGGATGGAACGACTGGACACAGGTACCCTTCTGTTCACACCAT TTTCACGAGTTAATTATGAAAGATGGTCGCACACTCGTAGTTCCATGCAGAAACCAAGAT GAATTGATCGGCAGAGCCCGAATTTCCCAGGGAGCTGGGTGGTCTTTACGGGAGACGGCC TGTTTGGGGAAGTCTTACGCCCAAATGTGGAGCTTGATGTACTTCCACAGACGTGATCTC AGGCTAGCGGCAAATGCCATCTGCTCGGCAGTCCCGTCACACTGGGTTCCAACAAGCCGG ACAACCTGGTCCATACACGCCAGCCATGAATGGATGACGACGGAAGACATGTTGACAGTT TGGAACAAAGTGTGGATCCTAGAAAATCCATGGATGGAAGACAAAACTCCAGTGGAATCA TGGGAGGAAATCCCATACCTGGGAAAAAGAGAAGACCAATGGTGCGGCTCACTGATTGGG CTGACAAGCAGAGCCACCTGGGCGAAGAATATCCAGACAGCAATAAACCAAGTCAGATCC CTCATTGGCAATGAGGAATACACAGATTACATGCCATCCATGAAAAGATTCAGAAGAGAA GAGGAAGAGGCAGGAGTTTTGTGGTAG
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P12823 UniProtKB Entry Name POLG_DEN2P GenBank Protein ID 323655 GenBank Gene ID M19197 - General References
- Hahn YS, Galler R, Hunkapiller T, Dalrymple JM, Strauss JH, Strauss EG: Nucleotide sequence of dengue 2 RNA and comparison of the encoded proteins with those of other flaviviruses. Virology. 1988 Jan;162(1):167-80. [Article]
- Wright PJ, Cauchi MR, Ng ML: Definition of the carboxy termini of the three glycoproteins specified by dengue virus type 2. Virology. 1989 Jul;171(1):61-7. [Article]
- Egloff MP, Benarroch D, Selisko B, Romette JL, Canard B: An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization. EMBO J. 2002 Jun 3;21(11):2757-68. [Article]
- Modis Y, Ogata S, Clements D, Harrison SC: A ligand-binding pocket in the dengue virus envelope glycoprotein. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6986-91. Epub 2003 May 20. [Article]
- Zhang Y, Corver J, Chipman PR, Zhang W, Pletnev SV, Sedlak D, Baker TS, Strauss JH, Kuhn RJ, Rossmann MG: Structures of immature flavivirus particles. EMBO J. 2003 Jun 2;22(11):2604-13. [Article]