Thymidylate synthase
Details
- Name
- Thymidylate synthase
- Synonyms
- 2.1.1.45
- TS
- Gene Name
- THYA
- Organism
- Pneumocystis carinii
- Amino acid sequence
>lcl|BSEQ0012190|Thymidylate synthase MVNAEEQQYLNLVQYIINHGEDRPDRTGTGTLSVFAPSPLKFSLRNKTFPLLTTKRVFIR GVIEELLWFIRGETDSLKLREKNIHIWDANGSREYLDSIGLTKRQEGDLGPIYGFQWRHF GAEYIDCKTNYIGQGVDQLANIIQKIRTSPYDRRLILSAWNPADLEKMALPPCHMFCQFY VHIPSNNHRPELSCQLYQRSCDMGLGVPFNIASYALLTCMIAHVCDLDPGDFIHVMGDCH IYKDHIEALQQQLTRSPRPFPTLSLNRSITDIEDFTLDDFNIQNYHPYETIKMKMSI
- Number of residues
- 297
- Molecular Weight
- 34361.99
- Theoretical pI
- 6.58
- GO Classification
- Functionsthymidylate synthase activityProcessesdTMP biosynthetic process / dTTP biosynthetic process
- General Function
- Thymidylate synthase activity
- Specific Function
- Not Available
- Pfam Domain Function
- Thymidylat_synt (PF00303)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0006104|894 bp ATGGTAAACGCAGAAGAACAACAATATCTCAACTTAGTACAATATATTATTAACCATGGG GAAGACCGCCCTGATAGGACAGGGACAGGGACTTTATCTGTTTTTGCACCGTCTCCGCTA AAGTTTTCTCTTCGAAATAAAACATTTCCACTCTTAACAACCAAGCGAGTTTTTATACGT GGAGTAATTGAAGAATTGCTTTGGTTTATTCGTGGAGAAACAGATTCTTTAAAACTTAGA GAGAAAAATATTCATATATGGGATGCAAATGGATCACGAGAGTACCTTGACTCAATTGGA TTGACTAAACGCCAGGAAGGTGATCTTGGTCCCATTTATGGGTTTCAATGGAGGCATTTT GGAGCAGAATATATTGATTGCAAAACCAATTATATTGGACAAGGTGTTGATCAATTAGCC AATATTATCCAAAAAATACGAACATCACCATATGATCGTCGACTCATACTTTCAGCATGG AATCCTGCAGATTTAGAAAAAATGGCATTACCTCCGTGCCATATGTTTTGTCAGTTTTAT GTTCATATACCATCGAATAACCACCGACCTGAACTCTCATGTCAATTATACCAACGTTCT TGTGACATGGGGCTAGGTGTTCCCTTTAATATTGCATCGTATGCTCTACTAACATGCATG ATTGCACATGTTTGTGATCTTGATCCAGGTGATTTTATCCATGTCATGGGTGATTGTCAT ATTTATAAGGATCATATTGAAGCACTACAACAACAACTTACACGCTCCCCACGACCTTTT CCCACTCTTTCTTTAAATCGCTCAATCACTGATATTGAAGATTTTACATTAGATGATTTT AATATTCAAAACTATCATCCATATGAAACTATAAAAATGAAAATGTCCATTTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P13100 UniProtKB Entry Name TYSY_PNECA GenBank Gene ID M25415 - General References
- Edman U, Edman JC, Lundgren B, Santi DV: Isolation and expression of the Pneumocystis carinii thymidylate synthase gene. Proc Natl Acad Sci U S A. 1989 Sep;86(17):6503-7. [Article]
- Mazars E, Odberg-Ferragut C, Dei-Cas E, Fourmaux MN, Aliouat EM, Brun-Pascaud M, Mougeot G, Camus D: Polymorphism of the thymidylate synthase gene of Pneumocystis carinii from different host species. J Eukaryot Microbiol. 1995 Jan-Feb;42(1):26-32. [Article]
- Anderson AC, O'Neil RH, DeLano WL, Stroud RM: The structural mechanism for half-the-sites reactivity in an enzyme, thymidylate synthase, involves a relay of changes between subunits. Biochemistry. 1999 Oct 19;38(42):13829-36. [Article]