Beta-3 adrenergic receptor
Details
- Name
- Beta-3 adrenergic receptor
- Synonyms
- ADRB3R
- B3AR
- Beta-3 adrenoceptor
- Beta-3 adrenoreceptor
- Gene Name
- ADRB3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010709|Beta-3 adrenergic receptor MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
- Number of residues
- 408
- Molecular Weight
- 43518.615
- Theoretical pI
- 9.07
- GO Classification
- Functionsbeta-adrenergic receptor activity / beta3-adrenergic receptor activity / epinephrine binding / norepinephrine binding / protein homodimerization activityProcessesactivation of adenylate cyclase activity / adenylate cyclase-activating adrenergic receptor signaling pathway / adenylate cyclase-modulating G-protein coupled receptor signaling pathway / aging / brown fat cell differentiation / carbohydrate metabolic process / cell-cell signaling / diet induced thermogenesis / eating behavior / energy reserve metabolic process / G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / generation of precursor metabolites and energy / heat generation / negative regulation of multicellular organism growth / positive regulation of MAPK cascade / response to antibiotic / response to cold / temperature homeostasis / vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressureComponentsintegral component of plasma membrane / nucleus / plasma membrane / receptor complex
- General Function
- Protein homodimerization activity
- Specific Function
- Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 37-63 73-91 112-133 156-178 204-225 293-314 327-347
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010710|Beta-3 adrenergic receptor (ADRB3) ATGGCTCCGTGGCCTCACGAGAACAGCTCTCTTGCCCCATGGCCGGACCTCCCCACCCTG GCGCCCAATACCGCCAACACCAGTGGGCTGCCAGGGGTTCCGTGGGAGGCGGCCCTAGCC GGGGCCCTGCTGGCGCTGGCGGTGCTGGCCACCGTGGGAGGCAACCTGCTGGTCATCGTG GCCATCGCCTGGACTCCGAGACTCCAGACCATGACCAACGTGTTCGTGACTTCGCTGGCC GCAGCCGACCTGGTGATGGGACTCCTGGTGGTGCCGCCGGCGGCCACCTTGGCGCTGACT GGCCACTGGCCGTTGGGCGCCACTGGCTGCGAGCTGTGGACCTCGGTGGACGTGCTGTGT GTGACCGCCAGCATCGAAACCCTGTGCGCCCTGGCCGTGGACCGCTACCTGGCTGTGACC AACCCGCTGCGTTACGGCGCACTGGTCACCAAGCGCTGCGCCCGGACAGCTGTGGTCCTG GTGTGGGTCGTGTCGGCCGCGGTGTCGTTTGCGCCCATCATGAGCCAGTGGTGGCGCGTA GGGGCCGACGCCGAGGCGCAGCGCTGCCACTCCAACCCGCGCTGCTGTGCCTTCGCCTCC AACATGCCCTACGTGCTGCTGTCCTCCTCCGTCTCCTTCTACCTTCCTCTTCTCGTGATG CTCTTCGTCTACGCGCGGGTTTTCGTGGTGGCTACGCGCCAGCTGCGCTTGCTGCGCGGG GAGCTGGGCCGCTTTCCGCCCGAGGAGTCTCCGCCGGCGCCGTCGCGCTCTCTGGCCCCG GCCCCGGTGGGGACGTGCGCTCCGCCCGAAGGGGTGCCCGCCTGCGGCCGGCGGCCCGCG CGCCTCCTGCCTCTCCGGGAACACCGGGCCCTGTGCACCTTGGGTCTCATCATGGGCACC TTCACTCTCTGCTGGTTGCCCTTCTTTCTGGCCAACGTGCTGCGCGCCCTGGGGGGCCCC TCTCTAGTCCCGGGCCCGGCTTTCCTTGCCCTGAACTGGCTAGGTTATGCCAATTCTGCC TTCAACCCGCTCATCTACTGCCGCAGCCCGGACTTTCGCAGCGCCTTCCGCCGTCTTCTG TGCCGCTGCGGCCGTCGCCTGCCTCCGGAGCCCTGCGCCGCCGCCCGCCCGGCCCTCTTC CCCTCGGGCGTTCCTGCGGCCCGGAGCAGCCCAGCGCAGCCCAGGCTTTGCCAACGGCTC GACGGGGCTTCTTGGGGAGTTTCTTAG
- Chromosome Location
- 8
- Locus
- 8p12-p11.2
- External Identifiers
Resource Link UniProtKB ID P13945 UniProtKB Entry Name ADRB3_HUMAN GenBank Protein ID 178896 GenBank Gene ID M29932 GenAtlas ID ADRB3 HGNC ID HGNC:288 - General References
- Emorine LJ, Marullo S, Briend-Sutren MM, Patey G, Tate K, Delavier-Klutchko C, Strosberg AD: Molecular characterization of the human beta 3-adrenergic receptor. Science. 1989 Sep 8;245(4922):1118-21. [Article]
- van Spronsen A, Nahmias C, Krief S, Briend-Sutren MM, Strosberg AD, Emorine LJ: The promoter and intron/exon structure of the human and mouse beta 3-adrenergic-receptor genes. Eur J Biochem. 1993 May 1;213(3):1117-24. [Article]
- Lelias JM, Kaghad M, Rodriguez M, Chalon P, Bonnin J, Dupre I, Delpech B, Bensaid M, LeFur G, Ferrara P, et al.: Molecular cloning of a human beta 3-adrenergic receptor cDNA. FEBS Lett. 1993 Jun 14;324(2):127-30. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Granneman JG, Lahners KN, Rao DD: Rodent and human beta 3-adrenergic receptor genes contain an intron within the protein-coding block. Mol Pharmacol. 1992 Dec;42(6):964-70. [Article]
- Patwari P, Emilsson V, Schadt EE, Chutkow WA, Lee S, Marsili A, Zhang Y, Dobrin R, Cohen DE, Larsen PR, Zavacki AM, Fong LG, Young SG, Lee RT: The arrestin domain-containing 3 protein regulates body mass and energy expenditure. Cell Metab. 2011 Nov 2;14(5):671-83. doi: 10.1016/j.cmet.2011.08.011. Epub 2011 Oct 6. [Article]
- Clement K, Vaisse C, Manning BS, Basdevant A, Guy-Grand B, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD: Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med. 1995 Aug 10;333(6):352-4. [Article]
- Fujisawa T, Ikegami H, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Oga T, Ueda H, Shintani M, Fukuda M, Ogihara T: Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain. Diabetologia. 1996 Mar;39(3):349-52. [Article]
- Candelore MR, Deng L, Tota LM, Kelly LJ, Cascieri MA, Strader CD: Pharmacological characterization of a recently described human beta 3-adrenergic receptor mutant. Endocrinology. 1996 Jun;137(6):2638-41. [Article]
- Halushka MK, Fan JB, Bentley K, Hsie L, Shen N, Weder A, Cooper R, Lipshutz R, Chakravarti A: Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet. 1999 Jul;22(3):239-47. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00368 Norepinephrine approved yes agonist Details DB00571 Propranolol approved, investigational unknown antagonist Details DB05395 Amibegron investigational unknown Details DB06262 Droxidopa approved, investigational yes agonist Details DB06190 Solabegron investigational unknown agonist Details DB01288 Fenoterol approved, investigational unknown agonist Details DB01407 Clenbuterol approved, investigational, vet_approved unknown agonist Details DB01102 Arbutamine approved unknown agonist Details DB01064 Isoprenaline approved, investigational yes agonist Details DB08807 Bopindolol experimental unknown Details DB08808 Bupranolol experimental unknown antagonist Details DB01363 Ephedra sinica root nutraceutical yes agonist Details DB08893 Mirabegron approved yes agonist Details DB01001 Albuterol approved, vet_approved unknown Details DB00866 Alprenolol experimental, withdrawn unknown antagonist Details DB00983 Formoterol approved, investigational unknown agonist Details DB00938 Salmeterol approved unknown inverse agonist Details DB00871 Terbutaline approved unknown agonist Details DB00960 Pindolol approved, investigational unknown agonist Details DB01580 Oxprenolol approved unknown Details DB11124 Racepinephrine approved yes agonist Details DB04846 Celiprolol approved, investigational unknown agonist Details DB04861 Nebivolol approved, investigational unknown agonist Details DB14895 Vibegron approved, investigational yes agonist Details DB00320 Dihydroergotamine approved, investigational unknown agonist Details DB01118 Amiodarone approved, investigational yes inhibitordownregulator Details DB00182 Amphetamine approved, illicit, investigational unknown agonist Details DB00540 Nortriptyline approved unknown antagonist Details DB00726 Trimipramine approved unknown binder Details DB00334 Olanzapine approved, investigational no inhibitor Details DB00217 Bethanidine approved unknown antagonist Details DB01365 Mephentermine approved unknown agonist Details DB06726 Bufuralol experimental unknown antagonist Details DB13345 Dihydroergocristine approved, experimental yes antagonistagonist Details DB01049 Ergoloid mesylate approved yes antagonistagonist Details DB11273 Dihydroergocornine approved yes antagonistagonist Details DB11278 DL-Methylephedrine approved yes agonist Details DB00715 Paroxetine approved, investigational unknown inhibitor Details DB00785 Cryptenamine approved unknown inhibitorpotentiator Details DB00867 Ritodrine approved, investigational yes agonistdownregulator Details DB00264 Metoprolol approved, investigational unknown inhibitor Details