Estradiol 17-beta-dehydrogenase 1
Details
- Name
- Estradiol 17-beta-dehydrogenase 1
- Synonyms
- 1.1.1.62
- 17-beta-HSD 1
- 17-beta-hydroxysteroid dehydrogenase type 1
- 20 alpha-hydroxysteroid dehydrogenase
- 20-alpha-HSD
- E17KSR
- E2DH
- EDH17B1
- EDH17B2
- EDHB17
- Placental 17-beta-hydroxysteroid dehydrogenase
- SDR28C1
- Short chain dehydrogenase/reductase family 28C member 1
- Gene Name
- HSD17B1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009997|Estradiol 17-beta-dehydrogenase 1 MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSL ETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTV RMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVH LSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEV FLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGG GAGPGAEDEAGRGAVGDPELGDPPAAPQ
- Number of residues
- 328
- Molecular Weight
- 34949.715
- Theoretical pI
- 5.42
- GO Classification
- Functionscatalytic activity / estradiol 17-beta-dehydrogenase activity / testosterone dehydrogenase (NAD+) activityProcessesbone development / cellular response to metal ion / estrogen biosynthetic process / estrogen metabolic process / small molecule metabolic process / steroid biosynthetic process / steroid metabolic process / testosterone biosynthetic processComponentscytoplasm / cytosol / nuclear membrane / nucleoplasm
- General Function
- Testosterone dehydrogenase (nad+) activity
- Specific Function
- Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
- Pfam Domain Function
- adh_short (PF00106)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0009998|Estradiol 17-beta-dehydrogenase 1 (HSD17B1) ATGGCCCGCACCGTGGTGCTCATCACCGGCTGTTCCTCGGGCATCGGCCTGCACTTGGCC GTACGTCTGGCTTCAGATCCATCCCAGAGCTTCAAAGTGTATGCCACGTTGAGGGACCTG AAAACACAGGGCCGGCTGTGGGAGGCGGCCCGGGCCCTGGCATGCCCTCCGGGATCCCTG GAGACGTTGCAGCTGGACGTAAGGGACTCAAAATCCGTGGCCGCTGCCCGGGAACGCGTG ACTGAGGGCCGCGTGGACGTGCTGGTGTGTAACGCAGGCCTGGGCCTGCTGGGGCCGCTG GAGGCGCTGGGGGAGGACGCCGTGGCCTCTGTGCTGGACGTGAATGTAGTAGGGACTGTG CGGATGCTGCAGGCCTTCCTGCCAGACATGAAGAGGCGCGGTTCGGGACGCGTGTTGGTG ACCGGGAGCGTGGGAGGATTGATGGGGCTGCCTTTCAATGACGTTTATTGCGCCAGCAAG TTCGCGCTCGAAGGCTTATGCGAGAGTCTGGCGGTTCTGCTGCTGCCCTTTGGGGTCCAC TTGAGCCTGATCGAGTGCGGCCCAGTGCACACCGCCTTCATGGAGAAGGTGTTGGGCAGC CCAGAGGAGGTGCTGGACCGCACGGACATCCACACCTTCCACCGCTTCTACCAATACCTC GCCCACAGCAAGCAAGTCTTTCGCGAGGCGGCGCAGAACCCTGAGGAGGTGGCGGAGGTC TTCCTCACCGCTTTGCGCGCCCCGAAGCCGACCCTGCGCTACTTCACCACCGAGCGCTTC CTGCCCCTGCTGCGGATGCGCCTGGACGACCCCAGCGGCTCCAACTACGTCACCGCCATG CACCGGGAAGTGTTCGGCGACGTTCCGGCAAAGGCCGAGGCTGGGGCCGAGGCTGGGGGC GGGGCCGGGCCTGGGGCAGAGGACGAGGCCGGGCGCGGTGCGGTGGGGGACCCTGAGCTC GGCGATCCTCCGGCCGCCCCGCAGTAA
- Chromosome Location
- 17
- Locus
- 17q11-q21
- External Identifiers
Resource Link UniProtKB ID P14061 UniProtKB Entry Name DHB1_HUMAN GenBank Protein ID 23365 GenBank Gene ID X13440 GenAtlas ID HSD17B1 HGNC ID HGNC:5210 - General References
- Peltoketo H, Isomaa V, Maentausta O, Vihko R: Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA. FEBS Lett. 1988 Oct 24;239(1):73-7. [Article]
- Luu The V, Labrie C, Zhao HF, Couet J, Lachance Y, Simard J, Leblanc G, Cote J, Berube D, Gagne R, et al.: Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta. Mol Endocrinol. 1989 Aug;3(8):1301-9. [Article]
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- Burns DJ, Engel LL, Bethune JL: Amino acid composition and subunit structure. Human placental 17 -estradiol dehydrogenase. Biochemistry. 1972 Jul 4;11(14):2699-703. [Article]
- Nicolas JC, Harris JI: Human placental 17 -oestradiol dehydrogenase. Sequence of a tryptic peptide containing an essential cysteine. FEBS Lett. 1973 Jan 15;29(2):173-6. [Article]
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- Baker ME: Human placental 17 beta-hydroxysteroid dehydrogenase is homologous to NodG protein of Rhizobium meliloti. Mol Endocrinol. 1989 May;3(5):881-4. [Article]
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- Normand T, Narod S, Labrie F, Simard J: Detection of polymorphisms in the estradiol 17 beta-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11-q21. Hum Mol Genet. 1993 Apr;2(4):479-83. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00157 NADH approved, nutraceutical unknown Details DB02187 Equilin experimental unknown Details DB02323 EM-1745 experimental unknown Details DB01536 Androstenedione experimental, illicit yes inducer Details DB03461 Nicotinamide adenine dinucleotide phosphate experimental unknown Details DB02901 Stanolone illicit, investigational unknown Details DB01561 Androstanedione experimental, illicit unknown Details DB13951 Stanolone acetate experimental unknown Details DB01708 Prasterone approved, investigational, nutraceutical unknown substrate Details