Ribose-phosphate pyrophosphokinase
Details
- Name
- Ribose-phosphate pyrophosphokinase
- Synonyms
- 2.7.6.1
- 5-phospho-D-ribosyl alpha-1-diphosphate
- P-Rib-PP synthase
- Phosphoribosyl diphosphate synthase
- Phosphoribosyl pyrophosphate synthase
- PPRibP synthase
- PRPP synthase
- PRPPase
- RPPK
- Gene Name
- prs
- Organism
- Bacillus subtilis (strain 168)
- Amino acid sequence
>lcl|BSEQ0011193|Ribose-phosphate pyrophosphokinase MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDGEVQINIEESIRGCDCY IIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYARQDRKARSREPITAKLFAN LLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEYFEGKNLEDIVIVSPDHGGVT RARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGKTAILIDDIIDTAGTITLAANAL VENGAKEVYACCTHPVLSGPAVERINNSTIKELVVTNSIKLPEEKKIERFKQLSVGPLLA EAIIRVHEQQSVSYLFS
- Number of residues
- 317
- Molecular Weight
- 34867.88
- Theoretical pI
- 6.26
- GO Classification
- FunctionsATP binding / kinase activity / magnesium ion binding / ribose phosphate diphosphokinase activityProcesses5-phosphoribose 1-diphosphate biosynthetic process / nucleotide biosynthetic process / ribonucleoside monophosphate biosynthetic processComponentscytoplasm
- General Function
- Ribose phosphate diphosphokinase activity
- Specific Function
- Involved in the biosynthesis of ribose 1,5-bisphosphate. Catalyzes the transfer of pyrophosphoryl group from ATP to ribose-5-phosphate to yield phosphoribosyl diphosphate (PRPP) and AMP.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011194|Ribose-phosphate pyrophosphokinase (prs) ATGTCTAATCAATACGGAGATAAGAATTTAAAGATTTTTTCTTTGAATTCGAATCCAGAG CTTGCAAAAGAAATCGCAGATATAGTTGGAGTTCAATTAGGGAAATGTTCTGTCACAAGA TTTAGTGACGGGGAAGTCCAAATTAATATCGAAGAAAGTATTCGCGGATGTGATTGTTAC ATCATCCAGTCTACAAGTGACCCCGTTAACGAGCATATTATGGAACTGCTGATTATGGTA GATGCGTTAAAACGCGCTTCTGCAAAAACGATTAACATTGTTATTCCTTATTACGGTTAT GCGCGTCAAGACAGAAAAGCAAGATCCCGTGAGCCAATCACAGCTAAACTTTTCGCTAAC CTGCTTGAAACAGCCGGTGCGACTCGTGTGATTGCACTTGACCTGCATGCGCCGCAAATT CAAGGATTCTTTGATATACCGATTGACCACTTAATGGGTGTTCCGATTTTAGGAGAATAT TTTGAAGGCAAAAATCTTGAAGATATCGTCATTGTTTCACCAGACCATGGCGGTGTGACA CGTGCCCGCAAACTGGCTGACCGACTAAAAGCGCCAATTGCGATTATCGATAAACGCCGT CCGCGTCCAAACGTGGCGGAAGTCATGAATATTGTAGGTAACATCGAAGGGAAGACTGCT ATCCTCATCGATGACATTATTGATACTGCAGGTACGATTACACTTGCTGCTAATGCGCTC GTTGAAAACGGAGCGAAAGAAGTATATGCATGCTGTACACACCCTGTACTATCAGGCCCT GCGGTTGAACGGATTAATAATTCAACAATTAAAGAGCTTGTTGTGACAAACAGCATCAAG CTTCCTGAAGAAAAGAAAATTGAACGCTTTAAGCAGCTTTCAGTCGGACCGCTTCTGGCC GAAGCGATTATTCGCGTTCATGAGCAGCAATCAGTCAGCTATCTGTTCAGCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P14193 UniProtKB Entry Name KPRS_BACSU GenBank Protein ID 40218 GenBank Gene ID X16518 - General References
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- Arnvig K, Hove-Jensen B, Switzer RL: Purification and properties of phosphoribosyl-diphosphate synthetase from Bacillus subtilis. Eur J Biochem. 1990 Aug 28;192(1):195-200. [Article]
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