1-phosphatidylinositol phosphodiesterase
Details
- Name
- 1-phosphatidylinositol phosphodiesterase
- Synonyms
- 4.6.1.13
- Phosphatidylinositol diacylglycerol-lyase
- Phosphatidylinositol-specific phospholipase C
- PI-PLC
- Gene Name
- Not Available
- Organism
- Bacillus cereus
- Amino acid sequence
>lcl|BSEQ0011408|1-phosphatidylinositol phosphodiesterase MSNKKLILKLFICSTIFITFVFALHDKRVVAASSVNELENWSKWMQPIPDSIPLARISIP GTHDSGTFKLQNPIKQVWGMTQEYDFRYQMDHGARIFDIRGRLTDDNTIVLHHGPLYLYV TLHEFINEAKQFLKDNPSETIIMSLKKEYEDMKGAEDSFSSTFEKKYFVDPIFLKTEGNI KLGDARGKIVLLKRYSGSNEPGGYNNFYWPDNETFTTTVNQNANVTVQDKYKVSYDEKVK SIKDTMDETMNNSEDLNHLYINFTSLSSGGTAWNSPYYYASYINPEIANYIKQKNPARVG WVIQDYINEKWSPLLYQEVIRANKSLIKE
- Number of residues
- 329
- Molecular Weight
- 38108.93
- Theoretical pI
- 6.9
- GO Classification
- Functionsphosphatidylinositol diacylglycerol-lyase activity / phosphoric diester hydrolase activityProcesseslipid catabolic processComponentsextracellular region
- General Function
- Phosphoric diester hydrolase activity
- Specific Function
- Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates.
- Pfam Domain Function
- PI-PLC-X (PF00388)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0003872|990 bp ATGAGCAATAAGAAGTTAATTTTGAAATTATTCATATGTAGTACAATATTTATCACATTT GTATTTGCTTTACATGATAAGAGAGTAGTTGCAGCTAGCTCTGTTAATGAGCTTGAAAAT TGGTCAAAATGGATGCAACCTATACCTGATAGTATCCCGTTAGCACGAATTTCAATTCCA GGAACACACGATAGTGGGACGTTCAAGTTGCAAAATCCGATTAAGCAAGTATGGGGAATG ACGCAAGAATATGATTTTCGCTATCAAATGGACCATGGAGCTCGCATTTTTGATATAAGA GGACGTTTAACAGATGATAATACGATAGTTCTTCATCATGGGCCATTATATCTTTACGTA ACACTGCATGAATTCATAAATGAAGCGAAACAATTTTTAAAAGATAACCCGAGTGAAACA ATTATTATGTCTTTAAAAAAAGAGTATGAGGATATGAAAGGGGCAGAAGATTCATTTAGT AGCACGTTTGAAAAAAAATATTTTGTTGATCCTATTTTTTTAAAAACAGAAGGAAATATA AAGCTTGGAGATGCTCGTGGGAAAATTGTACTACTAAAAAGATATAGTGGTAGTAATGAA CCTGGAGGATATAATAATTTTTATTGGCCAGATAATGAGACGTTTACCACAACTGTAAAC CAAAATGCAAATGTAACAGTACAAGATAAATATAAAGTGAGCTATGATGAGAAAGTAAAA TCTATTAAAGATACGATGGATGAAACGATGAACAATAGCGAGGATTTAAATCATCTATAT ATTAATTTTACAAGCTTGTCTTCTGGTGGTACAGCATGGAATAGTCCATATTACTATGCC TCTTATATAAATCCTGAAATTGCAAACTATATAAAACAAAAGAATCCTGCGAGAGTAGGC TGGGTAATTCAAGACTACATAAATGAAAAGTGGTCACCATTATTGTATCAAGAAGTTATA AGAGCGAATAAGTCATTAATAAAAGAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P14262 UniProtKB Entry Name PLC_BACCE GenBank Protein ID 143340 GenBank Gene ID M30809 - General References
- Kuppe A, Evans LM, McMillen DA, Griffith OH: Phosphatidylinositol-specific phospholipase C of Bacillus cereus: cloning, sequencing, and relationship to other phospholipases. J Bacteriol. 1989 Nov;171(11):6077-83. [Article]
- Heinz DW, Ryan M, Bullock TL, Griffith OH: Crystal structure of the phosphatidylinositol-specific phospholipase C from Bacillus cereus in complex with myo-inositol. EMBO J. 1995 Aug 15;14(16):3855-63. [Article]
- Heinz DW, Ryan M, Smith MP, Weaver LH, Keana JF, Griffith OH: Crystal structure of phosphatidylinositol-specific phospholipase C from Bacillus cereus in complex with glucosaminyl(alpha 1-->6)-D-myo-inositol, an essential fragment of GPI anchors. Biochemistry. 1996 Jul 23;35(29):9496-504. [Article]
- Gassler CS, Ryan M, Liu T, Griffith OH, Heinz DW: Probing the roles of active site residues in phosphatidylinositol-specific phospholipase C from Bacillus cereus by site-directed mutagenesis. Biochemistry. 1997 Oct 21;36(42):12802-13. [Article]