Immunoglobulin lambda-like polypeptide 1
Details
- Name
- Immunoglobulin lambda-like polypeptide 1
- Synonyms
- CD179 antigen-like family member B
- Ig lambda-5
- IGL1
- Immunoglobulin omega polypeptide
- Immunoglobulin-related protein 14.1
- Gene Name
- IGLL1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049830|Immunoglobulin lambda-like polypeptide 1 MRPGTGQGGLEAPGEPGPNLRQRWPLLLLGLAVVTHGLLRPTAASQSRALGPGAPGGSSR SSLRSRWGRFLLQRGSWTGPRCWPRGFQSKHNSVTHVFGSGTQLTVLSQPKATPSVTLFP PSSEELQANKATLVCLMNDFYPGILTVTWKADGTPITQGVEMTTPSKQSNNKYAASSYLS LTPEQWRSRRSYSCQVMHEGSTVEKTVAPAECS
- Number of residues
- 213
- Molecular Weight
- 22962.89
- Theoretical pI
- Not Available
- GO Classification
- Functionsantigen binding / immunoglobulin receptor bindingProcessesB cell receptor signaling pathway / complement activation, classical pathway / defense response to bacterium / immune response / innate immune response / leukocyte migration / phagocytosis, engulfment / phagocytosis, recognition / positive regulation of B cell activationComponentsblood microparticle / external side of plasma membrane / extracellular exosome / extracellular region / immunoglobulin complex, circulating / membrane
- General Function
- Critical for B-cell development.
- Specific Function
- Antigen binding
- Pfam Domain Function
- C1-set (PF07654)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0049831|Immunoglobulin lambda-like polypeptide 1 (IGLL1) ATGAGGCCAGGGACAGGCCAGGGGGGCCTTGAGGCCCCTGGTGAGCCAGGCCCCAACCTC AGGCAGCGCTGGCCCCTGCTGCTGCTGGGTCTGGCCGTGGTAACCCATGGCCTGCTGCGC CCAACAGCTGCATCGCAGAGCAGGGCCCTGGGCCCTGGAGCCCCTGGAGGAAGCAGCCGG TCCAGCCTGAGGAGCCGGTGGGGCAGGTTCCTGCTCCAGCGCGGCTCCTGGACTGGCCCC AGGTGCTGGCCCCGGGGGTTTCAATCCAAGCATAACTCAGTGACGCATGTGTTTGGCAGC GGGACCCAGCTCACCGTTTTAAGTCAGCCCAAGGCCACCCCCTCGGTCACTCTGTTCCCG CCGTCCTCTGAGGAGCTCCAAGCCAACAAGGCTACACTGGTGTGTCTCATGAATGACTTT TATCCGGGAATCTTGACGGTGACCTGGAAGGCAGATGGTACCCCCATCACCCAGGGCGTG GAGATGACCACGCCCTCCAAACAGAGCAACAACAAGTACGCGGCCAGCAGCTACCTGAGC CTGACGCCCGAGCAGTGGAGGTCCCGCAGAAGCTACAGCTGCCAGGTCATGCACGAAGGG AGCACCGTGGAGAAGACGGTGGCCCCTGCAGAATGTTCATAG
- Chromosome Location
- 22
- Locus
- 22q11.23
- External Identifiers
Resource Link UniProtKB ID P15814 UniProtKB Entry Name IGLL1_HUMAN HGNC ID HGNC:5870 - General References
- Hollis GF, Evans RJ, Stafford-Hollis JM, Korsmeyer SJ, McKearn JP: Immunoglobulin lambda light-chain-related genes 14.1 and 16.1 are expressed in pre-B cells and may encode the human immunoglobulin omega light-chain protein. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5552-6. [Article]
- Evans RJ, Hollis GF: Genomic structure of the human Ig lambda 1 gene suggests that it may be expressed as an Ig lambda 14.1-like protein or as a canonical B cell Ig lambda light chain: implications for Ig lambda gene evolution. J Exp Med. 1991 Feb 1;173(2):305-11. [Article]
- Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. [Article]
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- Schiff C, Bensmana M, Guglielmi P, Milili M, Lefranc MP, Fougereau M: The immunoglobulin lambda-like gene cluster (14.1, 16.1 and F lambda 1) contains gene(s) selectively expressed in pre-B cells and is the human counterpart of the mouse lambda 5 gene. Int Immunol. 1990;2(3):201-7. [Article]
- Chang H, Dmitrovsky E, Hieter PA, Mitchell K, Leder P, Turoczi L, Kirsch IR, Hollis GF: Identification of three new Ig lambda-like genes in man. J Exp Med. 1986 Feb 1;163(2):425-35. [Article]
- Minegishi Y, Coustan-Smith E, Wang YH, Cooper MD, Campana D, Conley ME: Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemia. J Exp Med. 1998 Jan 5;187(1):71-7. [Article]
- Bankovich AJ, Raunser S, Juo ZS, Walz T, Davis MM, Garcia KC: Structural insight into pre-B cell receptor function. Science. 2007 Apr 13;316(5822):291-4. [Article]