Bactericidal permeability-increasing protein
Details
- Name
- Bactericidal permeability-increasing protein
- Synonyms
- BPI
- CAP 57
- Gene Name
- BPI
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0010777|Bactericidal permeability-increasing protein MRENMARGPCNAPRWASLMVLVAIGTAVTAAVNPGVVVRISQKGLDYASQQGTAALQKEL KRIKIPDYSDSFKIKHLGKGHYSFYSMDIREFQLPSSQISMVPNVGLKFSISNANIKISG KWKAQKRFLKMSGNFDLSIEGMSISADLKLGSNPTSGKPTITCSSCSSHINSVHVHISKS KVGWLIQLFHKKIESALRNKMNSQVCEKVTNSVSSELQPYFQTLPVMTKIDSVAGINYGL VAPPATTAETLDVQMKGEFYSENHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLV YQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKKFPNMKIQIHVSASTPPHLSVQ PTGLTFYPAVDVQAFAVLPNSSLASLFLIGMHTTGSMEVSAESNRLVGELKLDRLLLELK HSNIGPFPVELLQDIMNYIVPILVLPRVNEKLQKGFPLPTPARVQLYNVVLQPHQNFLLF GADVVYK
- Number of residues
- 487
- Molecular Weight
- 53899.3
- Theoretical pI
- 10.0
- GO Classification
- Functionslipopolysaccharide bindingProcessesdefense response to Gram-negative bacterium / immune response / negative regulation of interleukin-6 production / negative regulation of interleukin-8 production / negative regulation of macrophage activation / negative regulation of tumor necrosis factor productionComponentscytoplasm / extracellular exosome / extracellular space / integral component of plasma membrane
- General Function
- Lipopolysaccharide binding
- Specific Function
- The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0010778|Bactericidal permeability-increasing protein (BPI) ATGAGAGAGAACATGGCCAGGGGCCCTTGCAACGCGCCGAGATGGGCGTCCCTGATGGTG CTGGTCGCCATAGGCACCGCCGTGACAGCGGCCGTCAACCCTGGCGTCGTGGTCAGGATC TCCCAGAAGGGCCTGGACTACGCCAGCCAGCAGGGGACGGCCGCTCTGCAGAAGGAGCTG AAGAGGATCAAGATTCCTGACTACTCAGACAGCTTTAAGATCAAGCATCTTGGGAAGGGG CATTATAGCTTCTACAGCATGGACATCCGTGAATTCCAGCTTCCCAGTTCCCAGATAAGC ATGGTGCCCAATGTGGGCCTTAAGTTCTCCATCAGCAACGCCAATATCAAGATCAGCGGG AAATGGAAGGCACAAAAGAGATTCTTAAAAATGAGCGGCAATTTTGACCTGAGCATAGAA GGCATGTCCATTTCGGCTGATCTGAAGCTGGGCAGTAACCCCACGTCAGGCAAGCCCACC ATCACCTGCTCCAGCTGCAGCAGCCACATCAACAGTGTCCACGTGCACATCTCAAAGAGC AAAGTGGGGTGGCTGATCCAACTCTTCCACAAAAAAATTGAGTCTGCGCTTCGAAACAAG ATGAACAGCCAGGTCTGCGAGAAAGTGACCAATTCTGTATCCTCCGAGCTGCAACCTTAT TTCCAGACTCTGCCAGTAATGACCAAAATAGATTCTGTGGCTGGAATCAACTATGGTCTG GTGGCACCTCCAGCAACCACGGCTGAGACCCTGGATGTACAGATGAAGGGGGAGTTTTAC AGTGAGAACCACCACAATCCACCTCCCTTTGCTCCACCAGTGATGGAGTTTCCCGCTGCC CATGACCGCATGGTATACCTGGGCCTCTCAGACTACTTCTTCAACACAGCCGGGCTTGTA TACCAAGAGGCTGGGGTCTTGAAGATGACCCTTAGAGATGACATGATTCCAAAGGAGTCC AAATTTCGACTGACAACCAAGTTCTTTGGAACCTTCCTACCTGAGGTGGCCAAGAAGTTT CCCAACATGAAGATACAGATCCATGTCTCAGCCTCCACCCCGCCACACCTGTCTGTGCAG CCCACCGGCCTTACCTTCTACCCTGCCGTGGATGTCCAGGCCTTTGCCGTCCTCCCCAAC TCCTCCCTGGCTTCCCTCTTCCTGATTGGCATGCACACAACTGGTTCCATGGAGGTCAGC GCCGAGTCCAACAGGCTTGTTGGAGAGCTCAAGCTGGATAGGCTGCTCCTGGAACTGAAG CACTCAAATATTGGCCCCTTCCCGGTTGAATTGCTGCAGGATATCATGAACTACATTGTA CCCATTCTTGTGCTGCCCAGGGTTAACGAGAAACTACAGAAAGGCTTCCCTCTCCCGACG CCGGCCAGAGTCCAGCTCTACAACGTAGTGCTTCAGCCTCACCAGAACTTCCTGCTGTTC GGTGCAGACGTTGTCTATAAATGA
- Chromosome Location
- 20
- Locus
- 20q11.23-q12
- External Identifiers
Resource Link UniProtKB ID P17213 UniProtKB Entry Name BPI_HUMAN GenBank Protein ID 179529 GenBank Gene ID J04739 GenAtlas ID BPI HGNC ID HGNC:1095 - General References
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