Cation-dependent mannose-6-phosphate receptor
Details
- Name
- Cation-dependent mannose-6-phosphate receptor
- Synonyms
- 46 kDa mannose 6-phosphate receptor
- CD Man-6-P receptor
- MPR 46
- MPR46
- MPRD
- Gene Name
- M6PR
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0013144|Cation-dependent mannose-6-phosphate receptor MFPFYSCWRTGLLLLLLAVAVRESWQTEEKTCDLVGEKGKESEKELALVKRLKPLFNKSF ESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIML IYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACS PEISHLSVGSILLVTFASLVAVYVVGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGC DFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
- Number of residues
- 277
- Molecular Weight
- 30993.06
- Theoretical pI
- Not Available
- GO Classification
- Functionsmannose binding / mannose transmembrane transporter activity / transmembrane signaling receptor activityProcessesendosome to lysosome transport / receptor-mediated endocytosis / signal transductionComponentsendosome / integral component of plasma membrane / late endosome / lysosomal membrane / membrane / perinuclear region of cytoplasm
- General Function
- Transmembrane signaling receptor activity
- Specific Function
- Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
- Pfam Domain Function
- Man-6-P_recep (PF02157)
- Transmembrane Regions
- 186-210
- Cellular Location
- Lysosome membrane
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P20645 UniProtKB Entry Name MPRD_HUMAN HGNC ID HGNC:6752 - General References
- Pohlmann R, Nagel G, Schmidt B, Stein M, Lorkowski G, Krentler C, Cully J, Meyer HE, Grzeschik KH, Mersmann G, et al.: Cloning of a cDNA encoding the human cation-dependent mannose 6-phosphate-specific receptor. Proc Natl Acad Sci U S A. 1987 Aug;84(16):5575-9. [Article]
- Klier HJ, von Figura K, Pohlmann R: Isolation and analysis of the human 46-kDa mannose 6-phosphate receptor gene. Eur J Biochem. 1991 Apr 10;197(1):23-8. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02755 1-3 Sugar Ring of Pentamannosyl 6-Phosphate experimental unknown Details DB02900 alpha-D-mannose 6-phosphate experimental unknown Details DB01272 Alglucosidase alfa approved yes binder Details DB00103 Agalsidase beta approved, investigational unknown substrate Details DB15874 Agalsidase alfa approved unknown substrate Details