Cannabinoid receptor 1
Details
- Name
- Cannabinoid receptor 1
- Synonyms
- CANN6
- CB-R
- CNR
- Gene Name
- CNR1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000122|Cannabinoid receptor 1 MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
- Number of residues
- 472
- Molecular Weight
- 52857.365
- Theoretical pI
- 8.25
- GO Classification
- Functionscannabinoid receptor activity / drug bindingProcessesadenylate cyclase-modulating G-protein coupled receptor signaling pathway / aging / axonal fasciculation / cannabinoid signaling pathway / G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / glucose homeostasis / maternal process involved in female pregnancy / memory / negative regulation of action potential / negative regulation of blood pressure / negative regulation of dopamine secretion / negative regulation of fatty acid beta-oxidation / negative regulation of mast cell activation / negative regulation of nitric-oxide synthase activity / positive regulation of acute inflammatory response to antigenic stimulus / positive regulation of apoptotic process / positive regulation of blood pressure / positive regulation of fever generation / positive regulation of neuron projection development / regulation of feeding behavior / regulation of insulin secretion / regulation of penile erection / regulation of synaptic transmission, GABAergic / regulation of synaptic transmission, glutamatergic / response to cocaine / response to ethanol / response to lipopolysaccharide / response to morphine / response to nicotine / response to nutrient / sensory perception of pain / spermatogenesisComponentsaxon / growth cone / integral component of plasma membrane / intracellular membrane-bounded organelle / membrane raft / plasma membrane
- General Function
- Drug binding
- Specific Function
- Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 117-142 155-175 188-212 233-255 274-299 345-365 378-399
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010146|Cannabinoid receptor 1 (CNR1) ATGAAGTCGATCCTAGATGGCCTTGCAGATACCACCTTCCGCACCATCACCACTGACCTC CTGTACGTGGGCTCAAATGACATTCAGTACGAAGACATCAAAGGTGACATGGCATCCAAA TTAGGGTACTTCCCACAGAAATTCCCTTTAACTTCCTTTAGGGGAAGTCCCTTCCAAGAG AAGATGACTGCGGGAGACAACCCCCAGCTAGTCCCAGCAGACCAGGTGAACATTACAGAA TTTTACAACAAGTCTCTCTCGTCCTTCAAGGAGAATGAGGAGAACATCCAGTGTGGGGAG AACTTCATGGACATAGAGTGTTTCATGGTCCTGAACCCCAGCCAGCAGCTGGCCATTGCA GTCCTGTCCCTCACGCTGGGCACCTTCACGGTCCTGGAGAACCTCCTGGTGCTGTGCGTC ATCCTCCACTCCCGCAGCCTCCGCTGCAGGCCTTCCTACCACTTCATCGGCAGCCTGGCG GTGGCAGACCTCCTGGGGAGTGTCATTTTTGTCTACAGCTTCATTGACTTCCACGTGTTC CACCGCAAAGATAGCCGCAACGTGTTTCTGTTCAAACTGGGTGGGGTCACGGCCTCCTTC ACTGCCTCCGTGGGCAGCCTGTTCCTCACAGCCATCGACAGGTACATATCCATTCACAGG CCCCTGGCCTATAAGAGGATTGTCACCAGGCCCAAGGCCGTGGTGGCGTTTTGCCTGATG TGGACCATAGCCATTGTGATCGCCGTGCTGCCTCTCCTGGGCTGGAACTGCGAGAAACTG CAATCTGTTTGCTCAGACATTTTCCCACACATTGATGAAACCTACCTGATGTTCTGGATC GGGGTCACCAGCGTACTGCTTCTGTTCATCGTGTATGCGTACATGTATATTCTCTGGAAG GCTCACAGCCACGCCGTCCGCATGATTCAGCGTGGCACCCAGAAGAGCATCATCATCCAC ACGTCTGAGGATGGGAAGGTACAGGTGACCCGGCCAGACCAAGCCCGCATGGACATTAGG TTAGCCAAGACCCTGGTCCTGATCCTGGTGGTGTTGATCATCTGCTGGGGCCCTCTGCTT GCAATCATGGTGTATGATGTCTTTGGGAAGATGAACAAGCTCATTAAGACGGTGTTTGCA TTCTGCAGTATGCTCTGCCTGCTGAACTCCACCGTGAACCCCATCATCTATGCTCTGAGG AGTAAGGACCTGCGACACGCTTTCCGGAGCATGTTTCCCTCTTGTGAAGGCACTGCGCAG CCTCTGGATAACAGCATGGGGGACTCGGACTGCCTGCACAAACACGCAAACAATGCAGCC AGTGTTCACAGGGCCGCAGAAAGCTGCATCAAGAGCACGGTCAAGATTGCCAAGGTAACC ATGTCTGTGTCCACAGACACGTCTGCCGAGGCTCTGTGA
- Chromosome Location
- 6
- Locus
- 6q14-q15
- External Identifiers
Resource Link UniProtKB ID P21554 UniProtKB Entry Name CNR1_HUMAN GenBank Protein ID 29915 GenBank Gene ID X54937 GenAtlas ID CNR1 HGNC ID HGNC:2159 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00470 Dronabinol approved, illicit yes agonist Details DB00486 Nabilone approved, investigational yes partial agonist Details DB05201 V24343 investigational unknown Details DB11745 Otenabant investigational unknown Details DB05077 SLV319 investigational unknown Details DB05750 AVE-1625 investigational unknown Details DB06155 Rimonabant approved, investigational yes antagonist Details DB02955 Ricinoleic acid experimental unknown Details DB09061 Cannabidiol approved, investigational yes antagonistmodulator Details DB09288 Propacetamol experimental yes antagonist Details DB14011 Nabiximols investigational yes Details DB14009 Medical Cannabis experimental, investigational yes negative modulator Details DB11755 Tetrahydrocannabivarin investigational yes antagonist Details