Gentamicin 3-N-acetyltransferase
Details
- Name
- Gentamicin 3-N-acetyltransferase
- Synonyms
- 2.3.1.60
- AAC(3)-I
- Aminoglycoside N(3)-acetyltransferase I
- Gentamicin acetyltransferase I
- Gene Name
- aacC1
- Organism
- Pseudomonas aeruginosa
- Amino acid sequence
>lcl|BSEQ0022421|Gentamicin 3-N-acetyltransferase MLRSSNDVTQQGSRPKTKLGGSSMGIIRTCRLGPDQVKSMRAALDLFGREFGDVATYSQH QPDSDYLGNLLRSKTFIALAAFDQEAVVGALAAYVLPRFEQPRSEIYIYDLAVSGEHRRQ GIATALINLLKHEANALGAYVIYVQADYGDDPAVALYTKLGIREEVMHFDIDPSTAT
- Number of residues
- 177
- Molecular Weight
- 19441.81
- Theoretical pI
- 6.11
- GO Classification
- Functionsaminoglycoside 3-N-acetyltransferase activityProcessesresponse to antibiotic
- General Function
- Aminoglycoside 3-n-acetyltransferase activity
- Specific Function
- Responsible for gentamicin resistance and has a limited substrate range.
- Pfam Domain Function
- Acetyltransf_1 (PF00583)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0003868|534 bp ATGTTACGCAGCAGCAACGATGTTACGCAGCAGGGCAGTCGCCCTAAAACAAAGTTAGGT GGCTCAAGTATGGGCATCATTCGCACATGTAGGCTCGGCCCTGACCAAGTCAAATCCATG CGGGCTGCTCTTGATCTTTTCGGTCGTGAGTTCGGAGACGTAGCCACCTACTCCCAACAT CAGCCGGACTCCGATTACCTCGGGAACTTGCTCCGTAGTAAGACATTCATCGCGCTTGCT GCCTTCGACCAAGAAGCGGTTGTTGGCGCTCTCGCGGCTTACGTTCTGCCCAGGTTTGAG CAGCCGCGTAGTGAGATCTATATCTATGATCTCGCAGTCTCCGGCGAGCACCGGAGGCAG GGCATTGCCACCGCGCTCATCAATCTCCTCAAGCATGAGGCCAACGCGCTTGGTGCTTAT GTGATCTACGTGCAAGCAGATTACGGTGACGATCCCGCAGTGGCTCTCTATACAAAGTTG GGCATACGGGAAGAAGTGATGCACTTTGATATCGACCCAAGTACCGCCACCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P23181 UniProtKB Entry Name AACC1_PSEAI GenBank Protein ID 530805 GenBank Gene ID U12338 - General References
- Wohlleben W, Arnold W, Bissonnette L, Pelletier A, Tanguay A, Roy PH, Gamboa GC, Barry GF, Aubert E, Davies J, et al.: On the evolution of Tn21-like multiresistance transposons: sequence analysis of the gene (aacC1) for gentamicin acetyltransferase-3-I(AAC(3)-I), another member of the Tn21-based expression cassette. Mol Gen Genet. 1989 Jun;217(2-3):202-8. [Article]
- Hsiang MW, White TJ, Davies JE: NH2-terminal sequence of the aminoglycoside acetyltransferase (3)-I mediated by plasmid RIP 135. FEBS Lett. 1978 Aug 1;92(1):97-9. [Article]