CAD protein
Details
- Name
- CAD protein
- Synonyms
- 6.3.5.5
- Gene Name
- CAD
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0016720|CAD protein MAALVLEDGSVLRGQPFGAAVSTAGEVVFQTGMVGYPEALTDPSYKAQILVLTYPLIGNY GIPPDEMDEFGLCKWFESSGIHVAALVVGECCPTPSHWSATRTLHEWLQQHGIPGLQGVD TRELTKKLREQGSLLGKLVQNGTEPSSLPFLDPNARPLVPEVSIKTPRVFNTGGAPRILA LDCGLKYNQIRCLCQRGAEVTVVPWDHALDSQEYEGLFLSNGPGDPASYPSVVSTLSRVL SEPNPRPVFGICLGHQLLALAIGAKTYKMRYGNRGHNQPCLLVGSGRCFLTSQNHGFAVE TDSLPADWAPLFTNANDGSNEGIVHNSLPFFSVQFHPEHQAGPSDMELLFDIFLETVKEA TAGNPGGQTVRERLTERLCPPGIPTPGSGLPPPRKVLILGSGGLSIGQAGEFDYSGSQAI KALKEENIQTLLINPNIATVQTSQGLADKVYFLPITPHYVTQVIRNERPDGVLLTFGGQT ALNCGVELTKAGVLARYGVRVLGTPVETIELTEDRRAFAARMAEIGEHVAPSEAANSLEQ AQAAAERLGYPVLVRAAFALGGLGSGFASNREELSALVAPAFAHTSQVLVDKSLKGWKEI EYEVVRDAYGNCVTVCNMENLDPLGIHTGESIVVAPSQTLNDREYQLLRQTAIKVTQHLG IVGECNVQYALNPESEQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPELRN SVTGGTAAFEPSVDYCVVKIPRWDLSKFLRVSTKIGSCMKSVGEVMGIGRSFEEAFQKAL RMVDENCVGFDHTVKPVSDMELETPTDKRIFVVAAALWAGYSVDRLYELTRIDRWFLHRM KRIIAHAQLLEQHRGQPLPPDLLQQAKCLGFSDKQIALAVLSTELAVRKLRQELGICPAV KQIDTVAAEWPAQTNYLYLTYWGTTHDLTFRTPHVLVLGSGVYRIGSSVEFDWCAVGCIQ QLRKMGYKTIMVNYNPETVSTDYDMCDRLYFDEISFEVVMDIYELENPEGVILSMGGQLP NNMAMALHRQQCRVLGTSPEAIDSAENRFKFSRLLDTIGISQPQWRELSDLESARQFCQT VGYPCVVRPSYVLSGAAMNVAYTDGDLERFLSSAAAVSKEHPVVISKFIQEAKEIDVDAV ASDGVVAAIAISEHVENAGVHSGDATLVTPPQDITAKTLERIKAIVHAVGQELQVTGPFN LQLIAKDDQLKVIECNVRVSRSFPFVSKTLGVDLVALATRVIMGEEVEPVGLMTGSGVVG VKVPQFSFSRLAGADVVLGVEMTSTGEVAGFGESRCEAYLKAMLSTGFKIPKKNILLTIG SYKNKSELLPTVRLLESLGYSLYASLGTADFYTEHGVKVTAVDWHFEEAVDGECPPQRSI LEQLAEKNFELVINLSMRGAGGRRLSSFVTKGYRTRRLAADFSVPLIIDIKCTKLFVEAL GQIGPAPPLKVHVDCMTSQKLVRLPGLIDVHVHLREPGGTHKEDFASGTAAALAGGITMV CAMPNTRPPIIDAPALALAQKLAEAGARCDFALFLGASSENAGTLGTVAGSAAGLKLYLN ETFSELRLDSVVQWMEHFETWPSHLPIVAHAEQQTVAAVLMVAQLTQRSVHICHVARKEE ILLIKAAKARGLPVTCEVAPHHLFLSHDDLERLGPGKGEVRPELGSRQDVEALWENMAVI DCFASDHAPHTLEEKCGSRPPPGFPGLETMLPLLLTAVSEGRLSLDDLLQRLHHNPRRIF HLPPQEDTYVEVDLEHEWTIPSHMPFSKAHWTPFEGQKVKGTVRRVVLRGEVAYIDGQVL VPPGYGQDVRKWPQGAVPQLPPSAPATSEMTTTPERPRRGIPGLPDGRFHLPPRIHRASD PGLPAEEPKEKSSRKVAEPELMGTPDGTCYPPPPVPRQASPQNLGTPGLLHPQTSPLLHS LVGQHILSVQQFTKDQMSHLFNVAHTLRMMVQKERSLDILKGKVMASMFYEVSTRTSSSF AAAMARLGGAVLSFSEATSSVQKGESLADSVQTMSCYADVVVLRHPQPGAVELAAKHCRR PVINAGDGVGEHPTQALLDIFTIREELGTVNGMTITMVGDLKHGRTVHSLACLLTQYRVS LRYVAPPSLRMPPTVRAFVASRGTKQEEFESIEEALPDTDVLYMTRIQKERFGSTQEYEA CFGQFILTPHIMTRAKKKMVVMHPMPRVNEISVEVDSDPRAAYFRQAENGMYIRMALLAT VLGRF
- Number of residues
- 2225
- Molecular Weight
- 242981.73
- Theoretical pI
- 6.42
- GO Classification
- Functionsaspartate binding / aspartate carbamoyltransferase activity / ATP binding / carbamoyl-phosphate synthase (ammonia) activity / carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity / dihydroorotase activity / enzyme binding / identical protein binding / protein kinase activity / zinc ion bindingProcesses'de novo' pyrimidine nucleobase biosynthetic process / 'de novo' UMP biosynthetic process / arginine biosynthetic process / cellular response to drug / cellular response to epidermal growth factor stimulus / drug metabolic process / female pregnancy / glutamine metabolic process / heart development / lactation / liver development / nucleobase-containing small molecule metabolic process / organ regeneration / peptidyl-threonine phosphorylation / protein autophosphorylation / pyrimidine nucleobase metabolic process / pyrimidine nucleoside biosynthetic process / response to amine / response to caffeine / response to cortisol / response to testosterone / small molecule metabolic process / urea cycle / UTP biosynthetic processComponentscell projection / cytoplasm / cytosol / extracellular exosome / membrane / neuronal cell body / nuclear matrix / nucleoplasm / nucleus / protein complex / terminal bouton
- General Function
- Zinc ion binding
- Specific Function
- This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase).
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0016721|CAD protein (CAD) ATGGCGGCCCTAGTGTTGGAGGACGGGTCGGTCCTGCGGGGCCAGCCCTTTGGGGCCGCC GTGTCGACTGCCGGGGAAGTGGTGTTTCAAACCGGCATGGTCGGCTACCCCGAGGCCCTC ACTGATCCCTCCTACAAGGCACAGATCTTAGTGCTCACCTATCCTCTGATCGGCAACTAT GGCATCCCCCCAGATGAAATGGATGAGTTCGGTCTCTGCAAGTGGTTTGAATCCTCGGGC ATCCACGTAGCAGCACTGGTAGTGGGAGAGTGCTGTCCTACTCCCAGCCACTGGAGTGCC ACCCGCACCCTGCATGAGTGGCTGCAGCAGCATGGCATCCCTGGCTTGCAAGGAGTAGAC ACTCGGGAGCTGACCAAGAAGTTGCGGGAACAGGGGTCTCTGCTGGGGAAGCTGGTCCAG AATGGAACAGAACCTTCATCCCTGCCATTCTTGGACCCCAATGCCCGCCCCCTGGTACCA GAGGTCTCCATTAAGACTCCACGGGTATTCAATACAGGGGGTGCCCCTCGGATCCTTGCT TTGGACTGTGGCCTCAAGTATAATCAGATCCGATGCCTCTGCCAGCGTGGGGCTGAGGTC ACTGTGGTACCCTGGGACCATGCACTAGACAGCCAAGAGTATGAGGGTCTCTTCTTAAGT AATGGGCCTGGTGACCCTGCCTCCTATCCCAGTGTCGTATCCACACTGAGCCGTGTTTTA TCTGAGCCTAATCCCCGACCTGTCTTTGGGATCTGCCTGGGACACCAGCTATTGGCCTTA GCCATTGGGGCCAAGACTTACAAGATGAGATATGGGAACCGAGGCCATAACCAGCCCTGC TTGTTGGTGGGCTCTGGGCGCTGCTTTCTGACATCCCAGAACCATGGGTTTGCTGTGGAG ACAGACTCACTGCCAGCAGACTGGGCTCCTCTCTTCACCAACGCCAATGATGGTTCCAAT GAAGGCATTGTGCACAACAGCTTGCCTTTCTTCAGTGTCCAGTTTCACCCAGAGCACCAA GCTGGCCCTTCAGATATGGAACTGCTTTTCGATATCTTTCTGGAAACTGTGAAAGAGGCC ACAGCTGGGAACCCTGGGGGCCAGACAGTTAGAGAGCGGCTGACTGAGCGCCTCTGTCCC CCTGGGATTCCCACTCCCGGCTCTGGACTTCCACCACCACGAAAGGTTCTGATCCTGGGC TCAGGGGGCCTCTCCATTGGCCAAGCTGGAGAATTTGACTACTCGGGCTCTCAGGCAATT AAGGCCCTGAAGGAGGAAAACATCCAGACGTTGCTGATCAACCCCAATATTGCCACAGTG CAGACCTCCCAGGGGCTGGCCGACAAGGTCTATTTTCTTCCCATAACACCTCATTATGTA ACCCAGGTGATACGTAATGAACGCCCCGATGGTGTGTTACTGACTTTTGGGGGCCAGACT GCTCTGAACTGTGGTGTGGAGCTGACCAAGGCCGGGGTGCTGGCTCGGTATGGGGTCCGG GTCCTGGGCACACCAGTGGAGACCATTGAGCTGACCGAGGATCGACGGGCCTTTGCTGCC AGAATGGCAGAGATCGGAGAGCATGTGGCCCCGAGCGAGGCAGCAAATTCTCTTGAACAG GCCCAGGCAGCCGCTGAACGGCTGGGGTACCCTGTGCTAGTGCGTGCAGCCTTTGCCCTG GGTGGCCTGGGCTCTGGCTTTGCCTCTAACAGGGAGGAGCTCTCTGCTCTCGTGGCCCCA GCTTTTGCCCATACCAGCCAAGTGCTAGTAGACAAGTCTCTGAAGGGATGGAAGGAGATT GAGTACGAGGTGGTGAGAGACGCCTATGGCAACTGTGTCACGTATTACATCATTGAAGTG AATGCCAGGCTCTCTCGCAGCTCTGCCCTGGCCAGTAAGGCCACAGGTTATCCACTGGCT TATGTGGCAGCCAAGCTAGCATTGGGCATCCCTTTGCCTGAGCTCAGGAACTCTGTGACA GGGGGTACAGCAGCCTTTGAACCCAGCGTGGATTATTGTGTGGTGAAGATTCCTCGATGG GACCTTAGCAAGTTCCTGCGAGTCAGCACAAAGATTGGGAGCTGCATGAAGAGCGTTGGT GAAGTCATGGGCATTGGGCGTTCATTTGAGGAGGCCTTCCAGAAGGCCCTGCGCATGGTG GATGAGAACTGTGTGGGCTTTGATCACACAGTGAAACCAGTCAGCGATATGGAGTTGGAG ACTCCAACAGATAAGCGGATTTTTGTGGTGGCAGCTGCTTTGTGGGCTGGTTATTCAGTG GACCGCCTGTATGAGCTCACACGCATCGACCGCTGGTTCCTGCACCGAATGAAGCGTATC ATCGCACATGCCCAGCTGCTAGAACAACACCGTGGACAGCCTTTGCCGCCAGACCTGCTG CAACAGGCCAAGTGTCTTGGCTTCTCAGACAAACAGATTGCCCTTGCAGTTCTGAGCACA GAGCTGGCTGTTCGCAAGCTGCGTCAGGAACTGGGGATCTGTCCAGCAGTGAAACAGATT GACACAGTTGCAGCTGAGTGGCCAGCCCAGACAAATTACCTATACCTAACGTATTGGGGC ACCACCCATGACCTCACCTTTCGAACACCTCATGTCCTAGTCCTTGGCTCTGGCGTCTAC CGTATTGGCTCTAGCGTTGAATTTGACTGGTGTGCTGTAGGCTGCATCCAGCAGCTCCGA AAGATGGGATATAAGACCATCATGGTGAACTATAACCCAGAGACAGTCAGCACCGACTAT GACATGTGTGATCGACTCTACTTTGATGAGATCTCTTTTGAGGTGGTGATGGACATCTAT GAGCTCGAGAACCCTGAAGGTGTGATCCTATCCATGGGTGGACAGCTGCCCAACAACATG GCCATGGCGTTGCATCGGCAGCAGTGCCGGGTGCTGGGCACCTCCCCTGAAGCCATTGAC TCGGCTGAGAACCGTTTCAAGTTTTCCCGGCTCCTTGACACCATTGGTATCAGCCAGCCT CAGTGGAGGGAGCTCAGTGACCTCGAGTCTGCTCGCCAATTCTGCCAGACCGTGGGGTAC CCCTGTGTGGTGCGCCCCTCCTATGTGCTGAGCGGTGCTGCTATGAATGTGGCCTACACG GATGGAGACCTGGAGCGCTTCCTGAGCAGCGCAGCAGCCGTCTCCAAAGAGCATCCCGTG GTCATCTCCAAGTTCATCCAGGAGGCTAAGGAGATTGACGTGGATGCCGTGGCCTCTGAT GGTGTGGTGGCAGCCATCGCCATCTCTGAGCATGTGGAGAATGCAGGTGTGCATTCAGGT GATGCGACGCTGGTGACCCCCCCACAAGATATCACTGCCAAAACCCTGGAGCGGATCAAA GCCATTGTGCATGCTGTGGGCCAGGAGCTACAGGTCACAGGACCCTTCAATCTGCAGCTC ATTGCCAAGGATGACCAGCTGAAAGTTATTGAATGCAACGTACGTGTCTCTCGCTCCTTC CCCTTCGTTTCCAAGACACTGGGTGTGGACCTAGTAGCCTTGGCCACGCGGGTCATCATG GGGGAAGAAGTGGAACCTGTGGGGCTAATGACTGGTTCTGGAGTCGTGGGAGTAAAGGTG CCTCAGTTCTCCTTCTCCCGCTTGGCGGGTGCTGACGTGGTGTTGGGTGTGGAAATGACC AGTACTGGGGAGGTGGCCGGCTTTGGGGAGAGCCGCTGTGAGGCATACCTCAAGGCCATG CTAAGCACTGGCTTTAAGATCCCCAAGAAGAATATCCTGCTGACCATTGGCAGCTATAAG AACAAAAGCGAGCTGCTCCCAACTGTGCGGCTACTGGAGAGCCTGGGCTACAGCCTCTAT GCCAGTCTCGGCACAGCTGACTTCTACACTGAGCATGGCGTCAAGGTAACAGCTGTGGAC TGGCACTTTGAGGAGGCTGTGGATGGTGAGTGCCCACCACAGCGGAGCATCCTGGAGCAG CTAGCTGAGAAAAACTTTGAGCTGGTGATTAACCTGTCAATGCGTGGAGCTGGGGGCCGG CGTCTCTCTTCCTTTGTCACCAAGGGCTACCGCACCCGACGCTTGGCCGCTGACTTCTCC GTGCCCCTAATCATCGATATCAAGTGCACCAAACTCTTTGTGGAGGCCCTAGGCCAGATC GGGCCAGCCCCTCCTTTGAAGGTGCATGTTGACTGTATGACCTCCCAAAAGCTTGTGCGA CTGCCGGGATTGATTGATGTCCATGTGCACCTGCGGGAACCAGGTGGGACACATAAGGAG GACTTTGCTTCAGGCACAGCCGCTGCCCTGGCTGGGGGTATCACCATGGTGTGTGCCATG CCTAATACCCGGCCCCCCATCATTGACGCCCCTGCTCTGGCCCTGGCCCAGAAGCTGGCA GAGGCTGGCGCCCGGTGCGACTTTGCGCTATTCCTTGGGGCCTCGTCTGAAAATGCAGGA ACCTTGGGCACCGTGGCCGGGTCTGCAGCCGGGCTGAAGCTTTACCTCAATGAGACCTTC TCTGAGCTGCGGCTGGACAGCGTGGTCCAGTGGATGGAGCATTTCGAGACATGGCCCTCC CACCTCCCCATTGTGGCTCACGCAGAGCAGCAAACCGTGGCTGCTGTCCTCATGGTGGCT CAGCTCACTCAGCGCTCAGTGCACATATGTCACGTGGCACGGAAGGAGGAGATCCTGCTA ATTAAAGCTGCAAAGGCACGGGGCTTGCCAGTGACCTGCGAGGTGGCTCCCCACCACCTG TTCCTAAGCCATGATGACCTGGAGCGCCTGGGGCCTGGGAAGGGGGAGGTCCGGCCTGAG CTTGGCTCCCGCCAGGATGTGGAAGCCCTGTGGGAGAACATGGCTGTCATCGACTGCTTT GCCTCAGACCATGCTCCCCATACCTTGGAGGAGAAGTGTGGGTCCAGGCCCCCACCTGGG TTCCCAGGGTTAGAGACCATGCTGCCACTACTCCTGACGGCTGTAAGCGAGGGCCGGCTC AGCCTGGACGACCTGCTGCAGCGATTGCACCACAATCCTCGGCGCATCTTTCACCTGCCC CCGCAGGAGGACACCTATGTGGAGGTGGATCTGGAGCATGAGTGGACAATTCCCAGCCAC ATGCCCTTCTCCAAGGCCCACTGGACACCTTTTGAAGGGCAGAAAGTGAAGGGCACCGTC CGCCGTGTGGTCCTGCGAGGGGAGGTTGCCTATATCGATGGGCAGGTTCTGGTACCCCCG GGCTATGGACAGGATGTACGGAAGTGGCCACAGGGGGCTGTTCCTCAGCTCCCACCCTCA GCCCCTGCCACTAGTGAGATGACCACGACACCTGAAAGACCCCGCCGTGGCATCCCAGGG CTTCCTGATGGCCGCTTCCATCTGCCGCCCCGAATCCATCGAGCCTCCGACCCAGGTTTG CCAGCTGAGGAGCCAAAGGAGAAGTCCTCTCGGAAGGTAGCCGAGCCAGAGCTGATGGGA ACCCCTGATGGCACCTGCTACCCTCCACCACCAGTACCGAGACAGGCATCTCCCCAGAAC CTGGGGACCCCTGGCTTGCTGCACCCCCAGACCTCACCCCTGCTGCACTCATTAGTGGGC CAACATATCCTGTCCGTCCAGCAGTTCACCAAGGATCAGATGTCTCACCTGTTCAATGTG GCACACACACTGCGTATGATGGTGCAGAAGGAGCGGAGCCTCGACATCCTGAAGGGGAAG GTCATGGCCTCCATGTTCTATGAAGTGAGCACACGGACCAGCAGCTCCTTTGCAGCAGCC ATGGCCCGGCTGGGAGGTGCTGTGCTCAGCTTCTCGGAAGCCACATCGTCCGTCCAGAAG GGCGAATCCCTGGCTGACTCCGTGCAGACCATGAGCTGCTATGCCGACGTCGTCGTGCTC CGGCACCCCCAGCCTGGAGCAGTGGAGCTGGCCGCCAAGCACTGCCGGAGGCCAGTGATC AATGCTGGGGATGGGGTCGGAGAGCACCCCACCCAGGCCCTGCTGGACATCTTCACCATC CGTGAGGAGCTGGGAACTGTCAATGGCATGACGATCACGATGGTGGGTGACCTGAAGCAC GGACGCACAGTACATTCCCTGGCCTGCCTGCTCACCCAGTATCGTGTCAGCCTGCGCTAC GTGGCACCTCCCAGCCTGCGCATGCCACCCACTGTGCGGGCCTTCGTGGCCTCCCGCGGC ACCAAGCAGGAGGAATTCGAGAGCATTGAGGAGGCGCTGCCTGACACTGATGTGCTCTAC ATGACTCGAATCCAGAAGGAACGATTTGGCTCTACCCAGGAGTACGAAGCTTGCTTTGGT CAGTTCATCCTCACTCCCCACATCATGACCCGGGCCAAGAAGAAGATGGTGGTGATGCAC CCGATGCCCCGTGTCAACGAGATAAGCGTGGAAGTGGACTCGGATCCCCGCGCAGCCTAC TTCCGCCAGGCTGAGAACGGCATGTACATCCGCATGGCTCTGTTAGCCACCGTGCTGGGC CGTTTCTAG
- Chromosome Location
- 2
- Locus
- 2p22-p21
- External Identifiers
Resource Link UniProtKB ID P27708 UniProtKB Entry Name PYR1_HUMAN GenBank Protein ID 1228049 GenBank Gene ID D78586 GenAtlas ID CAD HGNC ID HGNC:1424 - General References
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