Calreticulin
Details
- Name
- Calreticulin
- Synonyms
- Calregulin
- CRP55
- CRTC
- Endoplasmic reticulum resident protein 60
- ERp60
- grp60
- HACBP
- Gene Name
- CALR
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0011528|Calreticulin MLLSVPLLLGLLGLAVAEPAVYFKEQFLDGDGWTSRWIESKHKSDFGKFVLSSGKFYGDE EKDKGLQTSQDARFYALSASFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPNSLDQT DMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDN TYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDASKPEDWDERAKIDDPTDSKPEDWDKPE HIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYS PDPSIYAYDNFGVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDK QDEEQRLKEEEEDKKRKEEEEAEDKEDDEDKDEDEEDEEDKEEDEEEDVPGQAKDEL
- Number of residues
- 417
- Molecular Weight
- 48141.2
- Theoretical pI
- 4.04
- GO Classification
- Functionsandrogen receptor binding / calcium ion binding / carbohydrate binding / chaperone binding / complement component C1q binding / DNA binding / glycoprotein binding / hormone binding / integrin binding / iron ion binding / mRNA binding / peptide binding / poly(A) RNA binding / protein binding involved in protein folding / ubiquitin protein ligase binding / unfolded protein binding / zinc ion bindingProcessesantigen processing and presentation of exogenous peptide antigen via MHC class I / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent / antigen processing and presentation of peptide antigen via MHC class I / ATF6-mediated unfolded protein response / cardiac muscle cell differentiation / cell cycle arrest / cellular calcium ion homeostasis / cellular protein metabolic process / cellular response to lithium ion / cellular senescence / chaperone-mediated protein folding / cortical actin cytoskeleton organization / endoplasmic reticulum unfolded protein response / glucocorticoid receptor signaling pathway / negative regulation of intracellular steroid hormone receptor signaling pathway / negative regulation of neuron differentiation / negative regulation of retinoic acid receptor signaling pathway / negative regulation of transcription from RNA polymerase II promoter / negative regulation of transcription, DNA-templated / negative regulation of translation / peptide antigen assembly with MHC class I protein complex / positive regulation of cell cycle / positive regulation of cell proliferation / positive regulation of dendritic cell chemotaxis / positive regulation of DNA replication / positive regulation of gene expression / positive regulation of phagocytosis / positive regulation of substrate adhesion-dependent cell spreading / post-translational protein modification / protein export from nucleus / protein folding / protein folding in endoplasmic reticulum / protein localization to nucleus / protein maturation by protein folding / protein N-linked glycosylation via asparagine / protein stabilization / receptor-mediated endocytosis / regulation of apoptotic process / regulation of meiotic nuclear division / regulation of transcription, DNA-templated / response to drug / response to estradiol / response to testosterone / sequestering of calcium ion / spermatogenesisComponentsacrosomal vesicle / cell surface / cytoplasm / cytosol / endocytic vesicle lumen / endoplasmic reticulum / endoplasmic reticulum lumen / external side of plasma membrane / extracellular exosome / extracellular region / extracellular space / focal adhesion / Golgi apparatus / integral component of lumenal side of endoplasmic reticulum membrane / intracellular / membrane / MHC class I peptide loading complex / nucleus / perinuclear region of cytoplasm / polysome / proteinaceous extracellular matrix / sarcoplasmic reticulum lumen / smooth endoplasmic reticulum
- General Function
- Zinc ion binding
- Specific Function
- Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).
- Pfam Domain Function
- Calreticulin (PF00262)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum lumen
- Gene sequence
>lcl|BSEQ0011529|Calreticulin (CALR) ATGCTGCTATCCGTGCCGCTGCTGCTCGGCCTCCTCGGCCTGGCCGTCGCCGAGCCTGCC GTCTACTTCAAGGAGCAGTTTCTGGACGGAGACGGGTGGACTTCCCGCTGGATCGAATCC AAACACAAGTCAGATTTTGGCAAATTCGTTCTCAGTTCCGGCAAGTTCTACGGTGACGAG GAGAAAGATAAAGGTTTGCAGACAAGCCAGGATGCACGCTTTTATGCTCTGTCGGCCAGT TTCGAGCCTTTCAGCAACAAAGGCCAGACGCTGGTGGTGCAGTTCACGGTGAAACATGAG CAGAACATCGACTGTGGGGGCGGCTATGTGAAGCTGTTTCCTAATAGTTTGGACCAGACA GACATGCACGGAGACTCAGAATACAACATCATGTTTGGTCCCGACATCTGTGGCCCTGGC ACCAAGAAGGTTCATGTCATCTTCAACTACAAGGGCAAGAACGTGCTGATCAACAAGGAC ATCCGTTGCAAGGATGATGAGTTTACACACCTGTACACACTGATTGTGCGGCCAGACAAC ACCTATGAGGTGAAGATTGACAACAGCCAGGTGGAGTCCGGCTCCTTGGAAGACGATTGG GACTTCCTGCCACCCAAGAAGATAAAGGATCCTGATGCTTCAAAACCGGAAGACTGGGAT GAGCGGGCCAAGATCGATGATCCCACAGACTCCAAGCCTGAGGACTGGGACAAGCCCGAG CATATCCCTGACCCTGATGCTAAGAAGCCCGAGGACTGGGATGAAGAGATGGACGGAGAG TGGGAACCCCCAGTGATTCAGAACCCTGAGTACAAGGGTGAGTGGAAGCCCCGGCAGATC GACAACCCAGATTACAAGGGCACTTGGATCCACCCAGAAATTGACAACCCCGAGTATTCT CCCGATCCCAGTATCTATGCCTATGATAACTTTGGCGTGCTGGGCCTGGACCTCTGGCAG GTCAAGTCTGGCACCATCTTTGACAACTTCCTCATCACCAACGATGAGGCATACGCTGAG GAGTTTGGCAACGAGACGTGGGGCGTAACAAAGGCAGCAGAGAAACAAATGAAGGACAAA CAGGACGAGGAGCAGAGGCTTAAGGAGGAGGAAGAAGACAAGAAACGCAAAGAGGAGGAG GAGGCAGAGGACAAGGAGGATGATGAGGACAAAGATGAGGATGAGGAGGATGAGGAGGAC AAGGAGGAAGATGAGGAGGAAGATGTCCCCGGCCAGGCCAAGGACGAGCTGTAG
- Chromosome Location
- 19
- Locus
- 19p13.3-p13.2
- External Identifiers
Resource Link UniProtKB ID P27797 UniProtKB Entry Name CALR_HUMAN GenBank Protein ID 337487 GenBank Gene ID M32294 GenAtlas ID CALR HGNC ID HGNC:1455 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00025 Antihemophilic factor, human recombinant approved, investigational unknown chaperone Details DB00031 Tenecteplase approved unknown Details DB06245 Lanoteplase investigational unknown Details DB01065 Melatonin approved, nutraceutical, vet_approved unknown Details DB11093 Calcium citrate approved, investigational no ligand Details DB11348 Calcium Phosphate approved no ligand Details DB09130 Copper approved, investigational unknown Details DB13998 Lonoctocog alfa approved, investigational unknown chaperone Details DB13999 Moroctocog alfa approved unknown chaperone Details DB13949 Ferric cation approved unknown binder Details DB14481 Calcium phosphate dihydrate approved no Details DB14520 Tetraferric tricitrate decahydrate approved unknown binder Details