Glutathione S-transferase Mu 2
Details
- Name
- Glutathione S-transferase Mu 2
- Synonyms
- 2.5.1.18
- GST class-mu 2
- GST4
- GSTM2-2
- Gene Name
- GSTM2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0002365|Glutathione S-transferase Mu 2 MPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL PYLIDGTHKITQSNAILRYIARKHNLCGESEKEQIREDILENQFMDSRMQLAKLCYDPDF EKLKPEYLQALPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPN LKDFISRFEGLEKISAYMKSSRFLPRPVFTKMAVWGNK
- Number of residues
- 218
- Molecular Weight
- 25744.395
- Theoretical pI
- 6.29
- GO Classification
- Functionsenzyme binding / glutathione binding / glutathione transferase activity / protein homodimerization activity / receptor bindingProcessescellular detoxification of nitrogen compound / cellular response to caffeine / glutathione derivative biosynthetic process / glutathione metabolic process / negative regulation of ryanodine-sensitive calcium-release channel activity / nitrobenzene metabolic process / positive regulation of ryanodine-sensitive calcium-release channel activity / regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion / relaxation of cardiac muscle / small molecule metabolic process / xenobiotic catabolic process / xenobiotic metabolic processComponentscytoplasm / cytosol / extracellular exosome / sarcoplasmic reticulum
- General Function
- Receptor binding
- Specific Function
- Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0016345|Glutathione S-transferase Mu 2 (GSTM2) ATGCCCATGACACTGGGGTACTGGAACATCCGCGGGCTGGCCCATTCCATCCGCCTGCTC CTGGAATACACAGACTCAAGCTACGAGGAAAAGAAGTACACGATGGGGGACGCTCCTGAT TATGACAGAAGCCAGTGGCTGAATGAAAAATTCAAGCTGGGCCTGGACTTTCCCAATCTG CCCTACTTGATTGATGGGACTCACAAGATCACCCAGAGCAACGCCATCCTGCGGTACATT GCCCGCAAGCACAACCTGTGCGGGGAATCAGAAAAGGAGCAGATTCGCGAAGACATTTTG GAGAACCAGTTTATGGACAGCCGTATGCAGCTGGCCAAACTCTGCTATGACCCAGATTTT GAGAAACTGAAACCAGAATACCTGCAGGCACTCCCTGAAATGCTGAAGCTCTACTCACAG TTTCTGGGGAAGCAGCCATGGTTTCTTGGGGACAAGATCACCTTTGTGGATTTCATCGCT TATGATGTCCTTGAGAGAAACCAAGTATTTGAGCCCAGCTGCCTGGATGCCTTCCCAAAC CTGAAGGACTTCATCTCCCGATTTGAGGGCTTGGAGAAGATCTCTGCCTACATGAAGTCC AGCCGCTTCCTCCCAAGACCTGTGTTCACAAAGATGGCTGTCTGGGGCAACAAGTAG
- Chromosome Location
- 1
- Locus
- 1p13.3
- External Identifiers
Resource Link UniProtKB ID P28161 UniProtKB Entry Name GSTM2_HUMAN GenBank Protein ID 183301 GenBank Gene ID M63509 GenAtlas ID GSTM2 HGNC ID HGNC:4634 - General References
- Vorachek WR, Pearson WR, Rule GS: Cloning, expression, and characterization of a class-mu glutathione transferase from human muscle, the product of the GST4 locus. Proc Natl Acad Sci U S A. 1991 May 15;88(10):4443-7. [Article]
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- Ross VL, Board PG: Molecular cloning and heterologous expression of an alternatively spliced human Mu class glutathione S-transferase transcript. Biochem J. 1993 Sep 1;294 ( Pt 2):373-80. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02458 S-(2,4-dinitrophenyl)glutathione experimental unknown Details DB03310 Glutathione disulfide approved, experimental, investigational unknown activator Details DB00143 Glutathione approved, investigational, nutraceutical unknown Details DB04701 S-Methyl glutathione experimental unknown Details DB03310 Glutathione disulfide approved, experimental, investigational unknown activator Details DB03619 Deoxycholic acid approved unknown inhibitor Details DB00321 Amitriptyline approved unknown inhibitor Details DB00291 Chlorambucil approved unknown substrate Details